Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. [PDF]
PLoS ONE, 2009 BACKGROUND:Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/beta ...
Desheng Lu +8 more
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Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent. [PDF]
Int J Mol Sci, 2023 Ethacrynic acid (ECA) is a diuretic that inhibits Na-K-2Cl cotransporter (NKCC2) present in the thick ascending loop of Henle and muculo dens and is clinically used for the treatment of edema caused by excessive body fluid.
Yu L, Lee H, Rho SB, Park MK, Lee CH.
europepmc +2 more sources
Ethacrynic acid is an inhibitor of human factor XIIIa [PDF]
BMC Pharmacology and Toxicology, 2022 Background Ethacrynic acid (EA) is a loop diuretic that is approved orally and parenterally to manage edema-associated diseases. Nevertheless, it was earlier reported that it is also associated with bleeding upon its parenteral administration.
Srabani Kar +3 more
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Improvement of the Chemical Reactivity of Michael Acceptor of Ethacrynic Acid Correlates with Antiproliferative Activities [PDF]
Molecules, 2023 The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (EA) analogs (6–10) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the aim to increase the chemical ...
Abdelmoula El Abbouchi +8 more
doaj +2 more sources
Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug [PDF]
Viruses, 2021 In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the Coronaviridae family, similar to the agent of SARS, referred to as SARS-CoV-2.
Camilla Isgrò +2 more
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Utilizing ethacrynic acid and ciclopirox olamine in liver cancer. [PDF]
Oncol Lett, 2018 Once aberrantly activated, the Wnt/β-catenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against β-catenin, as it serves a role on the cytoplasm and the nucleus ...
Al-Dali AM, Weiher H, Schmidt-Wolf IGH.
europepmc +2 more sources
Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus [PDF]
Clinics, 2018 OBJECTIVES: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type.
Tomoyuki Harada +2 more
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High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. [PDF]
Oncotarget, 2016 Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL).
Wu W +10 more
europepmc +2 more sources
Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer. [PDF]
Oncotarget, 2016 Prolonged treatment of breast cancer with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) often results in acquired resistance and a narrow therapeutic index.
Liu B +10 more
europepmc +2 more sources
Design, Synthesis, Computational Studies, and Anti-Proliferative Evaluation of Novel Ethacrynic Acid Derivatives Containing Nitrogen Heterocycle, Urea, and Thiourea Moieties as Anticancer Agents [PDF]
MoleculesIn the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported.
Abdelmoula El Abbouchi +8 more
doaj +2 more sources