Results 1 to 10 of about 2,686,486 (201)

Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus [PDF]

Clinics, 2018
OBJECTIVES: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type.
Tomoyuki Harada, Mitchell Fink, Ruy J. Cruz Jr   +2 more
doaj   +3 more sources

Ethacrynic acid is an inhibitor of human factor XIIIa [PDF]

BMC Pharmacology and Toxicology, 2022
Background Ethacrynic acid (EA) is a loop diuretic that is approved orally and parenterally to manage edema-associated diseases. Nevertheless, it was earlier reported that it is also associated with bleeding upon its parenteral administration.
Srabani Kar, Kayla Vu, Madhusoodanan Mottamal, Rami A. Al-Horani   +3 more
doaj   +2 more sources

Improvement of the Chemical Reactivity of Michael Acceptor of Ethacrynic Acid Correlates with Antiproliferative Activities [PDF]

Molecules, 2023
The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (EA) analogs (6–10) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the aim to increase the chemical ...
Abdelmoula El Abbouchi, Nabil El Brahmi, Marie-Aude Hiebel, Hamza Ghammaz, Elmostafa El Fahime, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli   +8 more
doaj   +2 more sources

Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug [PDF]

Viruses, 2021
In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the Coronaviridae family, similar to the agent of SARS, referred to as SARS-CoV-2.
Camilla Isgrò, Anna Maria Sardanelli, Luigi Leonardo Palese   +2 more
doaj   +2 more sources

Design, Synthesis, Computational Studies, and Anti-Proliferative Evaluation of Novel Ethacrynic Acid Derivatives Containing Nitrogen Heterocycle, Urea, and Thiourea Moieties as Anticancer Agents [PDF]

Molecules
In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported.
Abdelmoula El Abbouchi, Khaoula Mkhayar, Souad Elkhattabi, Nabil El Brahmi, Marie-Aude Hiebel, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli   +8 more
doaj   +2 more sources

Ethacrynic Oxadiazole 6u Induces Apoptosis by Targeting mTOR/c-Flip Axis and Noxa in Lymphoma Cells [PDF]

Biological Procedures Online
Background Evasion of apoptosis is a major cause of therapy failure in lymphoma. We studied a covalent compound 6u with an α, β-saturated carbonyl group derived from the diuretic drug ethacrynic acid to induce apoptosis of lymphoma cells by targeting ...
Yafei Kuang, Shuoyan Feng, Jinxiao Sun, Zhuomin Tan, Xuan Bao, Yongmi Huang, Yuetong Wang, Ping Gong, Samuel Waxman, Guisen Zhao, Jingyi Zhang, Yongkui Jing   +11 more
doaj   +2 more sources

Secreted filarial acetylcholine analogs modulate parasite reproduction and host physiology [PDF]

Nature Communications
Lymphatic filariasis, caused by Brugia malayi, leads to chronic lymphatic dysfunction and lymphedema. The molecular mechanisms underlying interactions between filarial worms and their hosts remain poorly understood.
Alexandra Grote, Lia Ficaro, Joseph Koussa, Rita A. Boateng, Daniela Chow, Johannes Morstein, Morgan E. Brisse, Jennifer Goldstein, Hongyu Wu, Yen-Chih Chen, Matthew Chung, Christopher Mederos, Niels Ringstad, Eric V. Dang, Alexander Aksenov, Heather D. Hickman, Denis Voronin, Dirk Trauner, Drew R. Jones, Elodie Ghedin   +19 more
doaj   +2 more sources

Chloride-dependent mechanisms contribute to urinary bladder smooth muscle contractility: Pharmacological and molecular evidence from rat bladder tissue [PDF]

Tzu Chi Medical Journal
Objectives: To investigate the functional role of chloride-dependent signaling pathways in urinary bladder smooth muscle (SM) contractility and to evaluate the expression of ClC-3 and CLCA4 in rat bladder tissue.
Yuh-Chen Kuo, Vincent F. S. Tsai, Shih-Ping Liu, Jyh-Horng Chen, Hong-Chiang Chang, Ju-Ton Hsieh   +5 more
doaj   +2 more sources

AaMYB114 promotes the coloration of Actinidia arguta by synthesizing and transporting anthocyanins [PDF]

BMC Plant Biology
Background Anthocyanin accumulation in plant tissues requires coordinated regulation of both biosynthesis and transport. In Actinidia arguta, these pigments determine visual quality while enhancing nutritional value and antioxidant capacity, yet the ...
Lingshuai Ye, Xu Zhan, Zhe Song, Xiaohan Li, Miaomiao Lin, Leiming Sun, Ran Wang, Yukuo Li, Xiujuan Qi   +8 more
doaj   +2 more sources

Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers. [PDF]

PLoS ONE
Glutathione S-transferase P1-1 (GST P1) is an important drug target as it is implicated in drug resistance. GST P1-1 inhibitors are typically non-productive analogues of glutathione which covers broad chemical space; hence it is likely that several ...
Sarah A P Pereira, Jonathan Vesin, Marc Chambon, Gerardo Turcatti, M Lúcia M F S Saraiva, Paul J Dyson   +5 more
doaj   +2 more sources