Results 31 to 40 of about 2,686,486 (201)

A typical enzyme activity for glutathione conjugation indicates exposure of pacu to pollutants

Neotropical Ichthyology, 2022
Functional enzyme assays to detect sublethal poisoning of Neotropical fish are paramount. Accordingly, we assayed a glutathione S-transferase (GST) activity in liver and kidney cytosols from Piaractus mesopotamicus injected with methyl parathion or benzo[
Frederico F. Bastos, Lin M. de Lima, Santiago A. L. Tobar, Vera L. F. Cunha Bastos, Jayme Cunha Bastos   +4 more
doaj   +1 more source

Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F]FAMT positron emission tomography

Journal of Pharmacological Sciences, 2016
A PET tracer for tumor imaging, 3-18F-l-α-methyl-tyrosine ([18F]FAMT), has advantages of high cancer-specificity and low physiological background. In clinical studies, FAMT-PET has been proved useful for the detection of malignant tumors and their ...
Ling Wei, Hideyuki Tominaga, Ryuichi Ohgaki, Pattama Wiriyasermkul, Kohei Hagiwara, Suguru Okuda, Kyoichi Kaira, Yukio Kato, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai   +10 more
doaj   +1 more source

REVERSING OF CHLORAMBUCIL RESISTANCE BY ETHACRYNIC-ACID IN A B-CELL PATIENT

, 1993
We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated.
GRASSI B, CARACCIOLO F, PETRINI M, RONCA G., CONTE, Angela, SABBATINI, Anna Maria Teresa, RONCA, GIOVANNI, PETRINI, MARIO, SABBATINI, ANTONIETTA RAFFAELLA MARIA, Conte A   +9 more
core   +1 more source

Expression proteomics study to determine metallodrug targets and optimal drug combinations

Scientific Reports, 2017
The emerging technique termed functional identification of target by expression proteomics (FITExP) has been shown to identify the key protein targets of anti-cancer drugs. Here, we use this approach to elucidate the proteins involved in the mechanism of
Ronald F. S. Lee, Alexey Chernobrovkin, Dorothea Rutishauser, Claire S. Allardyce, David Hacker, Kai Johnsson, Roman A. Zubarev, Paul J. Dyson   +7 more
doaj   +1 more source

Pharmacophore-Based Virtual Screening of Novel GSTP1-1 Inhibitors

Journal of the Turkish Chemical Society, Section A: Chemistry, 2018
Glutathione transferase enzymes play an important role in metabolism and detoxification of numerous xenobiotics, electrophilic drugs, environmental carcinogens, and products of oxidative stress in living organisms.
Kayhan Bolelli, Tugba Ertan-Bolelli
doaj   +1 more source

Effects of ethacrynic acid on ion transport and energy metabolism in slices of avian salt gland and of mammalian liver and kidney cortex [PDF]

, 1978
Ethacrynic acid greatly inhibited net transport of ions and aerobic, energyconserving metabolism in slices of avian salt gland, rat liver, and rat and guinea-pig kidney cortex.
Rossum, George D. V., Ernst, Stephen A.
core   +1 more source

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

Journal of Pharmaceutical Analysis, 2021
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes.
Agnieszka Potęga, Michał Kosno, Zofia Mazerska   +2 more
doaj   +1 more source

Exploring molecular structure (monomer & dimer), spectroscopic (FT-IR, FT-Raman, UV-Vis, NMR), TG/DTA, antibacterial and molecular docking investigation on 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy] acetic acid by DFT and wavefunction analysis

Chemical Physics Impact
The present work focused on molecular structure and various spectroscopic studies of 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy] acetic acid is also called as Ethacrynic acid (EA).
S. Asokan, S. Sebastian, B. Karthikeyan, S. Xavier, R. Ganapathi Raman, S. Silvan, S. Sangeetha Margreat, R. Sagayaraj   +7 more
doaj   +1 more source

Contrast-Associated Acute Kidney Injury Requiring Continuous Renal Replacement Therapy in A Neonate with Aortic Stenosis—A Case Report

Pediatric Reports, 2023
Background: Acute kidney injury occurs commonly in the Neonatal Intensive Care Unit and is associated with increased mortality and morbidity. We report a case of a neonate with congenital heart disease who developed acute kidney injury after cardiac ...
Catalin Cirstoveanu, Carmina Georgescu, Nicolae Ruxandra, Mihaela Bizubac, Eliza Cinteza, Corina Maria Vasile, Cristina Filip, Irina Margarint   +7 more
doaj   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source