Results 31 to 40 of about 5,945,207 (220)
Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity [PDF]
, 2016 Four arene osmium complexes were prepared containing derivatives of ethacrynic acid, a potent inhibitor of glutathione S-transferases, either by direct coordination or via N- or P-donor ligands.
Gabriele Agonigi +8 more
semanticscholar +2 more sources
The Mode of Action of Cyclo(l-Ala-l-Pro) in Inhibiting Aflatoxin Production of Aspergillus flavus
Toxins, 2017 Cyclo(l-Ala-l-Pro) inhibits aflatoxin production in aflatoxigenic fungi without affecting fungal growth. The mode of action of cyclo(l-Ala-l-Pro) in inhibiting aflatoxin production of Aspergillus flavus was investigated. A glutathione S-transferase (GST)
Kurin Iimura +5 more
doaj +1 more source
Marmoset glutathione transferases with ketosteroid isomerase activity
Biochemistry and Biophysics Reports, 2021 The common marmoset Callithrix jacchus encodes two glutathione transferase (GST) enzymes with ketosteroid double-bond isomerase activity. The most active enzyme is CjaGST A3-3 showing a specific activity with 5-androsten-3,17-dione (Δ5-AD) of 62.1 ± 1.8 ...
Aram Ismail +2 more
doaj +1 more source
Ototoxic effects and mechanisms of loop diuretics
Journal of Otology, 2016 Over the past two decades considerable progress has been made in understanding the ototoxic effects and mechanisms underlying loop diuretics. As typical representative of loop diuretics ethacrynic acid or furosemide only induces temporary hearing loss ...
Dalian Ding +8 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST).
Bangtian Xu +8 more
doaj +1 more source
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent ...
Wei-Chung Chiou +6 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers. Intracellular glutathione (GSH) detoxification of cisplatin under the catalysis of glutathione S-transferases (GST) plays important roles in the development of ...
Boyi Niu +7 more
doaj +1 more source
Characterization and functional analysis of four glutathione S-transferases from the migratory locust, Locusta migratoria. [PDF]
PLoS ONE, 2013 Glutathione S-transferases (GSTs) play an important role in detoxification of xenobiotics in both prokaryotic and eukaryotic cells. In this study, four GSTs (LmGSTd1, LmGSTs5, LmGSTt1, and LmGSTu1) representing different classes were identified from the ...
Guohua Qin +7 more
doaj +1 more source
A typical enzyme activity for glutathione conjugation indicates exposure of pacu to pollutants
Neotropical Ichthyology, 2022 Functional enzyme assays to detect sublethal poisoning of Neotropical fish are paramount. Accordingly, we assayed a glutathione S-transferase (GST) activity in liver and kidney cytosols from Piaractus mesopotamicus injected with methyl parathion or benzo[
Frederico F. Bastos +4 more
doaj +1 more source
Potent inhibitors of equine steroid isomerase EcaGST A3-3.
PLoS ONE, 2019 Equine glutathione transferase A3-3 (EcaGST A3-3) belongs to the superfamily of detoxication enzymes found in all higher organisms. However, it is also the most efficient steroid double-bond isomerase known in mammals.
Helena Lindström +3 more
doaj +1 more source