Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial. [PDF]
Crit Care, 2015 IntroductionClinical effects of furosemide (F) and ethacrynic acid (EA) continuous infusion on urine output (UO), fluid balance, and renal, cardiac, respiratory, and metabolic function were compared in infants undergoing surgery for congenital heart ...
Ricci Z +5 more
europepmc +3 more sources
Varying the metal to ethacrynic acid ratio in ruthenium(ii)/osmium(ii)-p-cymene conjugates
Journal of Inorganic Biochemistry, 2017 Following the identification of a ruthenium(II)-arene complex with an ethacrynic acid-modified imidazole ligand, which inhibits glutathione transferase (GST) and is cytotoxic to chemo-resistant cancer cells, a series of structurally related ruthenium(II)-
Emilia Paunescu +2 more
exaly +3 more sources
Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. [PDF]
Biomol Ther (Seoul), 2013 Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells.
Byun HJ +11 more
europepmc +2 more sources
An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues
Results in Chemistry, 2023 Ethacrynic acid (EA, Edecrin) is a well-known diuretic drug used in the treatment of high blood pressure and the swelling caused by diseases such as congestive heart failure, liver failure, and kidney failure.
Nabil El Brahmi +2 more
doaj +2 more sources
Ethacrynic acid analogues lacking the alpha,beta-unsaturated carbonyl unit--potential anti-metastatic drugs. [PDF]
Bioorg Med Chem Lett, 2010 A series of ethacrynic acid analogues, lacking the α,β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ.
Janser RF +11 more
europepmc +2 more sources
Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells. [PDF]
Bioorg Med Chem Lett, 2011 A series of ethacrynic acid analogues, lacking the α,β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, Hs578Ts(i)8 as well as of human prostate cancer cells ...
Bryant ZE +7 more
europepmc +2 more sources
Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid. [PDF]
Hear Res, 2010 Concurrent administration of a high dose of gentamicin (GM; 125 mg/kg IM) and ethacrynic acid (EA; 40 mg/kg IV) results in rapid destruction of virtually all cochlear hair cells; however, the cell death signaling pathways underlying this rapid form of ...
Ding D, Jiang H, Salvi RJ.
europepmc +2 more sources
AaMYB114 promotes the coloration of Actinidia arguta by synthesizing and transporting anthocyanins [PDF]
BMC Plant BiologyBackground Anthocyanin accumulation in plant tissues requires coordinated regulation of both biosynthesis and transport. In Actinidia arguta, these pigments determine visual quality while enhancing nutritional value and antioxidant capacity, yet the ...
Lingshuai Ye +8 more
doaj +2 more sources
Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers. [PDF]
PLoS ONEGlutathione S-transferase P1-1 (GST P1) is an important drug target as it is implicated in drug resistance. GST P1-1 inhibitors are typically non-productive analogues of glutathione which covers broad chemical space; hence it is likely that several ...
Sarah A P Pereira +5 more
doaj +2 more sources
Poa annua becomes the first weed to evolve resistance to indaziflam applied preemergence and early-postemergence. [PDF]
Pest Manag SciWe report the first confirmed global case of Poa annua evolving resistance to indaziflam applied both preemergence and early‐postemergence. Resistance intensified under cool temperatures, was not reversed by metabolic inhibitors, and was often linked to multiple resistance, underscoring urgent needs for integrated weed management.
Miranda JW, Gaines TA, Moretti ML.
europepmc +2 more sources