An overview on the synthesis and anticancer properties of ethacrynic acid and their analogues
Results in Chemistry, 2023 Ethacrynic acid (EA, Edecrin) is a well-known diuretic drug used in the treatment of high blood pressure and the swelling caused by diseases such as congestive heart failure, liver failure, and kidney failure.
Nabil El Brahmi +2 more
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Multilayered Prioritization of Graph Attention Autoencoder–Derived Drug Repurposing Candidates for COVID-19 [PDF]
PharmaceuticalsBackground/Objectives: The COVID-19 pandemic highlighted the critical need for drug repurposing. While computational graph-based approaches show promise, single analytical methods often fail to capture the complex pathological mechanisms needed for ...
Yusuke Nakayama +4 more
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, 2020 Excerpt Ethacrynic acid is a loop diuretic that gained FDA approval for widespread use in 1967. Unlike other loop diuretics, ethacrynic acid is a novel drug due to the absence of a sulfonamide group in its structure, allowing its use in critically ill ...
Aribo, Chade, Ng, Daniel
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Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel 1,2,4-Triazole-Functionalized Benzene-Sulfonate Derivatives as Potential Enzyme Inhibitors and Cytotoxicity in HepG2 Cells [PDF]
PharmaceuticalsBackground/Objectives: In this study, novel benzenesulfonate derivatives containing a 1,2,4-triazole ring were synthesized. Methods: Their molecular structures were characterized by IR, 1H NMR, and 13C NMR spectroscopy, together with Q-TOF LC/MS analyses.
Yasemin Ünver +5 more
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Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial. [PDF]
Crit Care, 2015 Clinical effects of furosemide (F) and ethacrynic acid (EA) continuous infusion on urine output (UO), fluid balance, and renal, cardiac, respiratory, and metabolic function were compared in infants undergoing surgery for congenital heart ...
Ricci Z +5 more
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Frontiers in Pharmacology, 2021 One consequence of ischemic stroke is disruption of intracellular ionic homeostasis. Intracellular overload of both Na+ and Ca2+ has been linked to neuronal death in this pathophysiological state.
Christopher Katnik, Javier Cuevas
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Microorganisms, 2023 Some members of the genus Acanthamoeba are facultative pathogens typically with a biphasic lifestyle: trophozoites and cysts. Acanthamoeba is capable of infecting the cornea, resulting in Acanthamoeba keratitis.
Alvaro de Obeso Fernández del Valle +4 more
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Riluzole‐Derived Benzo[d]thiazoles as CK1δ Inhibitors for Amyotrophic Lateral Sclerosis‐Related Neurodegeneration [PDF]
ChemMedChemRiluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Adorinni S +18 more
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Antioxidants, 2020 Glutathione S-transferases (GSTs) are essential sperm antioxidant enzymes involved in cell protection against oxidative stress and toxic chemicals, preserving sperm function and fertilising ability.
Marc Llavanera +8 more
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Bis-conjugation of Bioactive Molecules to Cisplatin-like Complexes through (2,2′-Bipyridine)-4,4′-Dicarboxylic Acid with Optimal Cytotoxicity Profile Provided by the Combination Ethacrynic Acid/Flurbiprofen [PDF]
, 2020 A facile route to PtII complexes doubly functionalized with bioactive molecules through a bipyridine-type ligand is described. Initially, ligands LEE (containing two ethacrynic acid units), LEF (ethacrynic acid+flurbiprofen) and LEB (ethacrynic acid ...
Pampaloni G. +8 more
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