Results 41 to 50 of about 2,686,486 (201)

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents

Journal of the American Geriatrics Society, Volume 74, Issue 2, Page 336-344, February 2026.
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes, Emmanuelle Belanger, Arman Oganisian, Richa Joshi, Xiao (Joyce) Wang, Lexie R. Grove, Kelsey L. Corcoran, Andrew R. Zullo   +7 more
wiley   +1 more source

Inhibitory effect of ethacrynic acid on chloride permeability

, 1976
Ethacrynic acid inhibits anion movements in ox red blood cells. The I50 for chloride is 7 X 10(-6) M. The inhibitory effect is instantaneous and completely reversed by washing the cells with a Ringer solution, suggesting that reaction with a membrane SH
R Motais, JL Cousin
core   +1 more source

Design, Synthesis, and Evaluation of EA-Sulfonamides and Indazole-Sulfonamides as Promising Anticancer Agents: Molecular Docking, ADME Prediction, and Molecular Dynamics Simulations

Chemistry
New EA-sulfonamides and indazole-sulfonamides were synthesized, characterized, and evaluated for their anticancer activities. The target compound structures were elucidated using various spectroscopic techniques such as NMR-{1H and 13C}, infrared ...
Nassima Saghdani, Nabil El Brahmi, Abdelmoula El Abbouchi, Rachid Haloui, Souad Elkhattabi, Gérald Guillaumet, Saïd El Kazzouli   +6 more
doaj   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Characterization of Affinity-Purified Isoforms of Acinetobacter calcoaceticus Y1 Glutathione Transferases

The Scientific World Journal, 2014
Glutathione transferases (GST) were purified from locally isolated bacteria, Acinetobacter calcoaceticus Y1, by glutathione-affinity chromatography and anion exchange, and their substrate specificities were investigated.
Chin-Soon Chee, Irene Kit-Ping Tan, Zazali Alias   +2 more
doaj   +1 more source

Biological significance of glutathione S-transferases in human sperm cells

Journal of Human Reproductive Sciences, 2019
Background: Oxidative stress is considered as one of the causes of male subfertility or infertility. Among antioxidant enzymes, the crucial role belongs to glutathione S-transferases (GSTs).
Roman V Fafula, Nataliya M Paranyak, Anna S Besedina, Dmytro Z Vorobets, Ulyana P Iefremova, Olena K Onufrovych, Zinoviy D Vorobets   +6 more
doaj   +1 more source

Alpha-class glutathione S-transferases in wild turkeys (Meleagris gallopavo): characterization and role in resistance to the carcinogenic mycotoxin aflatoxin B1. [PDF]

PLoS ONE, 2013
Domestic turkeys (Meleagris gallopavo) are one of the most susceptible animals known to the toxic effects of the mycotoxin aflatoxin B1 (AFB1), a potent human hepatocarcinogen, and universal maize contaminant.
Ji Eun Kim, Brett R Bunderson, Amanda Croasdell, Kent M Reed, Roger A Coulombe   +4 more
doaj   +1 more source

Hypotensive Effect of Ethacrynic Acid [PDF]

Circulation, 1965
Ethacrynic acid has been found to possess a similar antihypertensive action to the thiazide diuretics. The use of the two drugs together results in a greater fall in pressure than that obtained with either drug alone. When thiazide therapy is supplemented by ethacrynic acid and dietary restriction of sodium a substantial additional reduction in blood ...
J, CONWAY, G, LEONETTI
openaire   +2 more sources

Poa annua becomes the first weed to evolve resistance to indaziflam applied preemergence and early‐postemergence

Pest Management Science, Volume 82, Issue 1, Page 539-551, January 2026.
We report the first confirmed global case of Poa annua evolving resistance to indaziflam applied both preemergence and early‐postemergence. Resistance intensified under cool temperatures, was not reversed by metabolic inhibitors, and was often linked to multiple resistance, underscoring urgent needs for integrated weed management.
Joshua WA Miranda, Todd A Gaines, Marcelo L Moretti   +2 more
wiley   +1 more source