Results 41 to 50 of about 5,945,207 (220)

Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F]FAMT positron emission tomography

Journal of Pharmacological Sciences, 2016
A PET tracer for tumor imaging, 3-18F-l-α-methyl-tyrosine ([18F]FAMT), has advantages of high cancer-specificity and low physiological background. In clinical studies, FAMT-PET has been proved useful for the detection of malignant tumors and their ...
Ling Wei, Hideyuki Tominaga, Ryuichi Ohgaki, Pattama Wiriyasermkul, Kohei Hagiwara, Suguru Okuda, Kyoichi Kaira, Yukio Kato, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai   +10 more
doaj   +1 more source

Pharmacophore-Based Virtual Screening of Novel GSTP1-1 Inhibitors

Journal of the Turkish Chemical Society, Section A: Chemistry, 2018
Glutathione transferase enzymes play an important role in metabolism and detoxification of numerous xenobiotics, electrophilic drugs, environmental carcinogens, and products of oxidative stress in living organisms.
Kayhan Bolelli, Tugba Ertan-Bolelli
doaj   +1 more source

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

Journal of Pharmaceutical Analysis, 2021
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes.
Agnieszka Potęga, Michał Kosno, Zofia Mazerska   +2 more
doaj   +1 more source

Effects of ethacrynic acid on the isolated collecting tubule

, 1974
The effects of diuretic ethacrynic acid on osmotic water permeability were investigated in the isolated perfused collecting tubule of the rabbit kidney.
Abramow, Maurice, Maurice Abramow
core   +1 more source

Expression proteomics study to determine metallodrug targets and optimal drug combinations

Scientific Reports, 2017
The emerging technique termed functional identification of target by expression proteomics (FITExP) has been shown to identify the key protein targets of anti-cancer drugs. Here, we use this approach to elucidate the proteins involved in the mechanism of
Ronald F. S. Lee, Alexey Chernobrovkin, Dorothea Rutishauser, Claire S. Allardyce, David Hacker, Kai Johnsson, Roman A. Zubarev, Paul J. Dyson   +7 more
doaj   +1 more source

Contrast-Associated Acute Kidney Injury Requiring Continuous Renal Replacement Therapy in A Neonate with Aortic Stenosis—A Case Report

Pediatric Reports, 2023
Background: Acute kidney injury occurs commonly in the Neonatal Intensive Care Unit and is associated with increased mortality and morbidity. We report a case of a neonate with congenital heart disease who developed acute kidney injury after cardiac ...
Catalin Cirstoveanu, Carmina Georgescu, Nicolae Ruxandra, Mihaela Bizubac, Eliza Cinteza, Corina Maria Vasile, Cristina Filip, Irina Margarint   +7 more
doaj   +1 more source

Energetics of tubular sodium reabsorption sensitive to ethacrynic acid and ouabain

, 1982
Ouabain reduces renal oxygen consumption more extensively than ethacrynic acid despite similar natriuretic effects. Therefore, ethacrynic acid, which does not inhibit Na-K-ATPase, might stimulate energy metabolism unrelated to net sodium reabsorption ...
O. M. Sejersted, F. Kiil, P. A. Steen
core   +1 more source

Relative effects of furosemide and ethacrynic acid on ion transport and energy metabolism in slices of rat kidney-cortex [PDF]

, 1981
The effects of furosemide and ethacrynic acid have been studied using slices of rat kidney cortex incubated in a Ringer medium. At concentrations from 0.2–2.0 mM, furosemide had no significant effect on the tissue ATP content or on the metabolism ...
Rossum, George D. V., Russo, M. A., Ernst, Stephen A.   +2 more
core   +1 more source

Cysteine enhances in vivo natriuretic potency of ethacrynic acid in the rat

, 1990
Total renal blood flow, glomerular filtration rate, and renal excretory function were determined in anesthetized rats treated with intravenous infusion of ethacrynic acid, 0.36 mg∙min−1∙kg−1, alone or in combination with cysteine.
L. Dobrowolski, E. Kompanowska-Jezierska, J. Sadowski   +2 more
core   +1 more source

Exploring molecular structure (monomer & dimer), spectroscopic (FT-IR, FT-Raman, UV-Vis, NMR), TG/DTA, antibacterial and molecular docking investigation on 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy] acetic acid by DFT and wavefunction analysis

Chemical Physics Impact
The present work focused on molecular structure and various spectroscopic studies of 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy] acetic acid is also called as Ethacrynic acid (EA).
S. Asokan, S. Sebastian, B. Karthikeyan, S. Xavier, R. Ganapathi Raman, S. Silvan, S. Sangeetha Margreat, R. Sagayaraj   +7 more
doaj   +1 more source