Results 61 to 70 of about 5,945,207 (220)

Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma

Nanomaterials, 2015
During the chemotherapy of cancer, drug resistance is the first issue that chemotherapeutic drugs cannot be effectively used for the treatment of cancers repeatedly for a long term, and the main reason for this is that tumor cell detoxification is ...
Bing Han, Yanli Wang, Lan Wang, Zuhui Shang, Shuang Wang, Jin Pei   +5 more
doaj   +1 more source

Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure

European Journal of Heart Failure, Volume 27, Issue 12, Page 3123-3133, December 2025.
This study investigated the prognostic value of residual congestion phenotypes at discharge in acute heart failure. Patients with intravascular residual congestion had better diuretic responses and shorter hospital stays than those with tissue/combined residual congestion, but worse outcomes than decongested patients.
Daan C.H. Ceelen, Jozine M. ter Maaten, Geert H.D. Voordes, Gad Cotter, Beth A. Davison, Gerasimos Filippatos, Peter S. Pang, Claudio Gimpelewicz, John G.F. Cleland, G. Michael Felker, Barry Greenberg, Michael M. Givertz, Christopher M. O'Conner, John R. Teerlink, Marco Metra, Adriaan A. Voors   +15 more
wiley   +1 more source

Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
Pulmonary disorders remain a global health challenge. This review explores critical innovations in inhaled nanoparticle drug delivery systems focusing on their potential to revolutionize treatment strategies for a wide spectrum of pulmonary diseases. We highlight recent breakthroughs in carrier materials, performance evaluations in vitro and in vivo ...
Yunzhou Fan, Yuefang Zhou, Jing Zhao, Yutong Zhao   +3 more
wiley   +1 more source

Inhibitory effect of ethacrynic acid on chloride permeability

, 1976
Ethacrynic acid inhibits anion movements in ox red blood cells. The I50 for chloride is 7 X 10(-6) M. The inhibitory effect is instantaneous and completely reversed by washing the cells with a Ringer solution, suggesting that reaction with a membrane SH
R Motais, JL Cousin
core   +1 more source

Molecular characterisation of Entamoeba histolytica UDP-glucose 4-epimerase, an enzyme able to provide building blocks for cyst wall formation.

PLoS Neglected Tropical Diseases, 2023
In the human host, the protozoan parasite Entamoeba histolytica is adapted to a non-invasive lifestyle in the colon as well as to an invasive lifestyle in the mesenterial blood vessels and the liver.
Anna Nagode, Jorick Vanbeselaere, Zuzanna Dutkiewicz, Samantha Kaltenbrunner, Iain B H Wilson, Michael Duchêne   +5 more
doaj   +1 more source

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.

Structure, 1995
Background: Glutathione transferases (GSTs) constitute a family of isoenzymes that catalyze the conjugation of the tripeptide glutathione with a wide variety of hydrophobic compounds bearing an electrophilic functional group.
Alexander D. Cameron, Irmgard Sinning, G. L'hermite, B. Olin, P. Board, Bengt Mannervik, T. Jones   +6 more
semanticscholar   +2 more sources

Maternal Exposure to Medications and the Risk of Congenital and Early‐Onset Hearing Loss in Children: A Systematic Review and a Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 3, September 2025.
ABSTRACT Background Congenital hearing loss (CHL) affects approximately 1–2 in 1000 children and significantly impacts development. Exposure to medications during pregnancy may impact offspring hearing; however, the ototoxic effects of different drugs have not been systematically investigated.
Asli Sena Kücükyildiz, Mette Østergaard Thunbo, Christer Zøylner Swan, David P. Burgner, Jessica E. Miller, Therese Ovesen, Lars Henning Pedersen   +6 more
wiley   +1 more source

Effect of ethacrynic acid on the thick ascending limb of Henle's loop

, 1973
Effect of ethacrynic acid on the thick ascending limb of Henle's loop. Cortical thick ascending limbs of Henle's loop were dissected from rabbit kidneys and perfused in vitro.
Green, Nordica, Burg, Maurice
core   +1 more source

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

Neurobiology of Disease, 2012
TAR DNA-binding protein 43 (TDP-43) is a major component of ubiquitin-positive inclusion of TDP-43 proteinopathies including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinated inclusions, which is now referred to as ...
Yohei Iguchi, Masahisa Katsuno, Shinnosuke Takagi, Shinsuke Ishigaki, Jun-ichi Niwa, Masato Hasegawa, Fumiaki Tanaka, Gen Sobue   +7 more
doaj   +1 more source

Biochemical characterization and peptide mass fingerprinting of two glutathione transferases from Biomphalaria alexandrina snails (Gastropoda: Planorbidae)

Journal of Genetic Engineering and Biotechnology, 2022
Background The freshwater snails Biomphalaria alexandrina (Gastropoda: Planorbidae) has public health importance of being an intermediate host of Schistosoma mansoni, the parasite species that causes intestinal schistosomiasis in humans.
Abdel-Monem Abdalla, Ghada S. A. Abdel Karim   +1 more
doaj   +1 more source