Results 61 to 70 of about 2,686,486 (201)

In vitro cytotoxic, antioxidant, hemolytic and cytoprotective potential of promising ethacrynic acid derivatives [PDF]

, 2023
The present study aims to screen some pharmacological activities of three promising ethacrynic acid (EA) derivatives (P3, P4, and P5) containing a piperazine moiety.
Ben Mrid, R., Bouchmaa, N., Zyad, A., Bouargalne, Y., El Brahmi, N., Idir, A., Ait Mouse, H., El Kazzouli, S., El Abbouchi, A., Bousmina, M., Nhiri, M.   +10 more
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Ethacrynic acid inhibition of histamine release from rat mast cells: effect on cellular ATP levels and thiol groups

, 1983
The experiments concerned the effect of ethacrynic acid (0.5 mM) on the adenosine triphosphate (ATP) content of rat mast cells and the effect on histamine release induced by the ionophore A23187 (10 microM). Ethacrynic acid decreased the ATP level of the
Johansen, Torben
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Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, Volume 603, Issue 15, Page 4255-4291, 1 August 2025.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Effects of ethacrynic acid on the isolated collecting tubule

, 1974
The effects of diuretic ethacrynic acid on osmotic water permeability were investigated in the isolated perfused collecting tubule of the rabbit kidney.
Abramow, Maurice, Maurice Abramow
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Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, Volume 27, Issue 6, Page 994-1002, June 2025.
Among high‐risk patients with type 2 diabetes, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. CI, confidence interval; CKD, chronic kidney disease; CV, cardiovascular; HF, heart failure; HR, hazard ratio ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source

Cysteine enhances in vivo natriuretic potency of ethacrynic acid in the rat

, 1990
Total renal blood flow, glomerular filtration rate, and renal excretory function were determined in anesthetized rats treated with intravenous infusion of ethacrynic acid, 0.36 mg∙min−1∙kg−1, alone or in combination with cysteine.
L. Dobrowolski, E. Kompanowska-Jezierska, J. Sadowski   +2 more
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Structures of potential EhGalE inhibitors.

, 2023
(A) Ebselen, (B) Diethylstilbestrol (DES), (C) Ethacrynic acid (EA).
Iain B. H. Wilson (8373627), Zuzanna Dutkiewicz (8373621), Michael Duchêne (33139), Samantha Kaltenbrunner (16877793), Jorick Vanbeselaere (302957), Anna Nagode (16877790)   +5 more
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Biochemical characterization and peptide mass fingerprinting of two glutathione transferases from Biomphalaria alexandrina snails (Gastropoda: Planorbidae)

Journal of Genetic Engineering and Biotechnology, 2022
Background The freshwater snails Biomphalaria alexandrina (Gastropoda: Planorbidae) has public health importance of being an intermediate host of Schistosoma mansoni, the parasite species that causes intestinal schistosomiasis in humans.
Abdel-Monem Abdalla, Ghada S. A. Abdel Karim   +1 more
doaj   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Some effects of insect hormones on Na(^+), K(^+)-ATPase and fluid secretion by the malpighian tubules of locusta migratoria L [PDF]

, 1981
A study has been made on the effects of insect hormones on fluid secretion by the Malpighian tubules of Locusta, and on the Na(^+), K(^+)- ATPase activity in microsomal preparations of the tubules.
Donkin, Julie Ellison
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