Results 81 to 90 of about 2,686,486 (201)
, 1973 The vasodilator properties of isoproterenol, diazoxide, ethacrynic acid, and furosemide were compared in the isolated canine gracilis muscle perfused with arterial blood at a constant rate.
R. I. Ogilvie, P. Larochelle, E. Mikulic
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Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
Biochemistry Research International, 2016 Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT).
Patience Marimo +2 more
doaj +1 more source
Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo
Redox Biology, 2019 Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated
Archit Rastogi +4 more
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Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins
Acta Physiologica, Volume 240, Issue 6, June 2024.Abstract A disturbed mitochondrial function contributes to the pathology of many common diseases. These organelles are therefore important therapeutic targets. On the contrary, many adverse effects of drugs can be explained by a mitochondrial off‐target effect, in particular, due to an interaction with carrier proteins in the inner membrane.
Charlotte A. Hoogstraten +2 more
wiley +1 more source
, 1993 In the present study it has been shown that ethacrynic acid can inhibit glutathione S-transferase (GST) of the pi-class irreversibly. [14C]Ethacrynic acid, 0.8 nmol/nmol human P1-1 and 0.8 nmol/nmol rat GST 7-7 could be incorporated, resulting in 65-93 ...
Bogaards, J.J.P. +5 more
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, 1985 Glutamine and lactate oxidations provide the bulk of ATP required for sodium reabsorption in the dog kidney during chronic metabolic acidosis. Indirect evidence has suggested that glutamine is oxidized in the proximal convoluted tubule; if this is true,
Ching B. Chen, Mitchell L. Halperin
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Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases
, 1993 1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (μM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for α, μ and π-class, respectively. 2.
Bogaards, J.J.P. +3 more
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Effects of Ethacrynic Acid on Frog Gastric Mucosa in Chloride Solutions
, 1974 The addition of ethacrynic acid to a concentration of 1 mM in the nutrient solution bathing the frog gastric mucosa in vitro produced an immediate decrease in resistance followed by an increase in resistance and a decrease in H+ secretory rate.
Manuel Schwartz +3 more
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Ethacrynic Acid and Ciclopiroxolamine in Various Cancer Cells [PDF]
, 2018 Extensive data from both in vitro and animal studies have demonstrated the potency of a deregulated activated Wnt pathway. Herein, we report the antitumor effects of already established novel Wnt pathway inhibitors – ethacrynic acid (EA) and ...
Weiher, Hans +2 more
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, 1990 Ethacrynic acid, a potent inhibitor of glutathione S-transferases (GST), has been shown to enhance the cytotoxicity of chlorambucil in drug resistant cell lines, but a definite mechanism has not been established.
Bladeren, P.J. van +2 more
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