Results 81 to 90 of about 5,945,207 (220)
Archiv der Pharmazie, Volume 357, Issue 9, September 2024.A series of 1,2,4‐triazine‐sulfonamide hybrids (3a–r) was synthesized and evaluated for their inhibitory effects on acetylcholinesterase (AChE) and glutathione S‐transferase (GST). The hybrids demonstrated promising inhibition of both AChE and GST activities.
Przemysław Rozbicki +5 more
wiley +1 more source
, 1997 The potent diuretic drug ethacrynic acid has been tested in clinical trials as an adjuvant in chemotherapy. Its target is the detoxifying enzyme glutathione transferase which is often found overexpressed in cancer tissues.
CACCURI, ANNA MARIA +9 more
core +1 more source
Blood Advances, 2017 : Besides being a classical tumor suppressor, runt-related transcription factor 1 (RUNX1) is now widely recognized for its oncogenic role in the development of acute myeloid leukemia (AML).
Ken Morita +8 more
doaj +1 more source
Cancer Medicine, Volume 13, Issue 18, September 2024.A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for GST‐P was identified in the rat liver on the key finding of “rapid excretion of GST‐P into bile” obtained from 3D immunochemistry using a vibratome for the first time.
Kimihiko Satoh
wiley +1 more source
Ethacrynic Acid Ototoxicity Potentiation by Kanamycin [PDF]
Annals of Otology, Rhinology & Laryngology, 1973 The ototoxicity of ethacrynic acid and kanamycin in combination has been investigated during acute and chronic conditions of exposure. The effect of the combination of 10 mg/kg of ethacrynic acid and 100 mg/kg of kanamycin during both exposure conditions is manifested by a significantly greater drop in measured potentials than is present in the ...
J, Prazma, J P, Browder, N D, Fischer
openaire +2 more sources
Paediatric and Perinatal Epidemiology, Volume 38, Issue 6, Page 495-504, August 2024.Abstract Background Off‐label treatment of extremely preterm infants with diuretics and inhaled corticosteroids (ICS) for evolving bronchopulmonary dysplasia (BPD) is common. Their effectiveness in reducing mortality or BPD severity, and optimal treatment timing, are unclear.
Jonathan L. Slaughter +2 more
wiley +1 more source
Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
Biochemistry Research International, 2016 Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT).
Patience Marimo +2 more
doaj +1 more source
Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo
Redox Biology, 2019 Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated
Archit Rastogi +4 more
doaj +1 more source
Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins
Acta Physiologica, Volume 240, Issue 6, June 2024.Abstract A disturbed mitochondrial function contributes to the pathology of many common diseases. These organelles are therefore important therapeutic targets. On the contrary, many adverse effects of drugs can be explained by a mitochondrial off‐target effect, in particular, due to an interaction with carrier proteins in the inner membrane.
Charlotte A. Hoogstraten +2 more
wiley +1 more source
FEBS Open Bio, Volume 14, Issue 5, Page 726-739, May 2024.Glutathione transferases (GST) are involved in detoxification and immunomodulation, allowing the establishment and development of cestodes in the host. Taenia solium has a 24‐kDa GST sigma class inducible gene that encodes a stable enzyme in a wide range of pHs and temperatures. Its enzymatic activity differs from other GSTs in the parasite, suggesting
Ricardo Miranda‐Blancas +7 more
wiley +1 more source