Results 71 to 80 of about 2,686,486 (201)

Energetics of tubular sodium reabsorption sensitive to ethacrynic acid and ouabain

, 1982
Ouabain reduces renal oxygen consumption more extensively than ethacrynic acid despite similar natriuretic effects. Therefore, ethacrynic acid, which does not inhibit Na-K-ATPase, might stimulate energy metabolism unrelated to net sodium reabsorption ...
O. M. Sejersted, F. Kiil, P. A. Steen
core   +1 more source

Fish Fin‐Derived Non‐Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery

Advanced Science, Volume 12, Issue 6, February 10, 2025.
Inspired by the structure and reciprocating motion of fish dorsal fins, a drug‐eluting contact lens based on deformable microstructures for non‐invasive drug delivery is developed. The drug release rate can be adaptively adjusted to intraocular pressure changes and proactively regulated by cyclic ocular loads, enabling it to respond to elevated ...
Xu Li, Hui Li, Zihao Wang, Xianda Wang, Jinlong Zhang, Fengjiao Bin, Wei Chen, Hongyang Li, Dongmei Huo, Dengbao Xiao   +9 more
wiley   +1 more source

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands [PDF]

, 2015
Pyridine- and phosphine-based ligands modified with ethacrynic acid (a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)–arene complexes and to a ruthenium(III) NAMI-A type complex.
Biancalana, L., Tina Riedel (1328484), Niccolò Bartalucci (1573891), Dyson, P. J., Emilia Păunescu, Agonigi, Gabriele, Paunescu, Emilia, PAMPALONI, GUIDO, Emilia Păunescu (1376610), Paul J. Dyson (103515), Stefano Zacchini (1431607), Pâunescu, E., Riedel, T., Marchetti, F., Fabio Marchetti, Bartalucci, Niccolò, Agonigi, G., MARCHETTI, FABIO, Guido Pampaloni (1406266), Gabriele Agonigi, Zacchini, Stefano, Gabriele Agonigi (1573894), Fabio Marchetti (1322487), Paul J. Dyson, Stefano Zacchini, Guido Pampaloni, Dyson, Paul J., Riedel, Tina, Tina Riedel, Niccolò Bartalucci, Pamapaloni, G., Pəunescu, Emilia, Zacchini S, Bartalucci N, Marchetti F, Riedel T, Dyson PJ, Agonigi G, Pampaloni G, Păunescu E   +39 more
core   +1 more source

Observational study for multiparametric assessment of cardiac congestion in outpatient worsening heart failure (EVOLUTION)

European Journal of Heart Failure, Volume 27, Issue 2, Page 325-336, February 2025.
EVOLUTION study findings. KCCQ‐12, 12‐question Kansas City Cardiomyopathy Questionnaire; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide Abstract Aims We sought to characterize the clinical course of patients following worsening heart failure (WHF) treated in an outpatient setting and to identify factors associated with a poor response to standard
Gad Cotter, Beth Davison, Philip Janiak, Christopher Edwards, Maria Novosadova, Koji Takagi, Marie‐Laure Ozoux, Francesca Lawson, Hamlet Hayrapetyan, Hamayak Sisakian, Victor R. Ter‐Grigoryan, Katell Peoc'h, Alexandre Raynor, Paul Bruzeau, Alexis Nguyen, Alexandre Mebazaa   +15 more
wiley   +1 more source

Varying the metal to ethacrynic acid ratio in ruthenium(ii)/osmium(ii)-p-cymene conjugates

, 2017
Following the identification of a ruthenium(II)-arene complex with an ethacrynic acid-modified imidazole ligand, which inhibits glutathione transferase (GST) and is cytotoxic to chemo-resistant cancer cells, a series of structurally related ruthenium(II)-
Clavel, Catherine M., Soudani, Mylene, Dyson, Paul J., Paunescu, Emilia, Dyson PJ, Paul J. Dyson, Păunescu E, Soudani M, Clavel CM, Catherine M. Clavel, Emilia Păunescu, Mylène Soudani   +11 more
core   +1 more source

Catalysis of Silver catfish Major Hepatic Glutathione Transferase proceeds via rapid equilibrium sequential random Mechanism

Toxicology Reports, 2016
Fish hepatic glutathione transferases are connected with the elimination of intracellular pollutants and detoxification of organic micro-pollutants in their aquatic ecosystem. The two-substrate steady state kinetic mechanism of Silver catfish (Synodontis
Ayodele O. Kolawole
doaj   +1 more source

Synthesis and examination of 1,2,4‐triazine‐sulfonamide hybrids as potential inhibitory drugs: Inhibition effects on AChE and GST enzymes in silico and in vitro conditions

Archiv der Pharmazie, Volume 357, Issue 9, September 2024.
A series of 1,2,4‐triazine‐sulfonamide hybrids (3a–r) was synthesized and evaluated for their inhibitory effects on acetylcholinesterase (AChE) and glutathione S‐transferase (GST). The hybrids demonstrated promising inhibition of both AChE and GST activities.
Przemysław Rozbicki, Ercan Oğuz, Ewa Wolińska, Fikret Türkan, Adnan Cetin, Danuta Branowska   +5 more
wiley   +1 more source

Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions

Blood Advances, 2017
: Besides being a classical tumor suppressor, runt-related transcription factor 1 (RUNX1) is now widely recognized for its oncogenic role in the development of acute myeloid leukemia (AML).
Ken Morita, Shintaro Maeda, Kensho Suzuki, Hiroki Kiyose, Junichi Taniguchi, Pu Paul Liu, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo   +8 more
doaj   +1 more source

A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for glutathione S‐transferase P‐form (GST‐P) in rat livers: 3D analysis using a vibratome

Cancer Medicine, Volume 13, Issue 18, September 2024.
A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for GST‐P was identified in the rat liver on the key finding of “rapid excretion of GST‐P into bile” obtained from 3D immunochemistry using a vibratome for the first time.
Kimihiko Satoh
wiley   +1 more source

Estimating the effect of diuretics and inhaled corticosteroids for evolving bronchopulmonary dysplasia in preterm infants

Paediatric and Perinatal Epidemiology, Volume 38, Issue 6, Page 495-504, August 2024.
Abstract Background Off‐label treatment of extremely preterm infants with diuretics and inhaled corticosteroids (ICS) for evolving bronchopulmonary dysplasia (BPD) is common. Their effectiveness in reducing mortality or BPD severity, and optimal treatment timing, are unclear.
Jonathan L. Slaughter, Mark A. Klebanoff, Erinn M. Hade   +2 more
wiley   +1 more source