Results 71 to 80 of about 5,945,207 (220)

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, Volume 292, Issue 17, Page 4675-4693, September 2025.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, Volume 603, Issue 15, Page 4255-4291, 1 August 2025.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, Volume 27, Issue 6, Page 994-1002, June 2025.
Among high‐risk patients with type 2 diabetes, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. CI, confidence interval; CKD, chronic kidney disease; CV, cardiovascular; HF, heart failure; HR, hazard ratio ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source

Effects of Ethacrynic Acid on Frog Gastric Mucosa in Chloride Solutions

, 1974
The addition of ethacrynic acid to a concentration of 1 mM in the nutrient solution bathing the frog gastric mucosa in vitro produced an immediate decrease in resistance followed by an increase in resistance and a decrease in H+ secretory rate.
Manuel Schwartz, Axel K. Olson, Gaspar Carrasquer, Mumtaz A. Dinno   +3 more
core   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Hypotensive Effect of Ethacrynic Acid [PDF]

Circulation, 1965
Ethacrynic acid has been found to possess a similar antihypertensive action to the thiazide diuretics. The use of the two drugs together results in a greater fall in pressure than that obtained with either drug alone. When thiazide therapy is supplemented by ethacrynic acid and dietary restriction of sodium a substantial additional reduction in blood ...
J, CONWAY, G, LEONETTI
openaire   +2 more sources

Fish Fin‐Derived Non‐Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery

Advanced Science, Volume 12, Issue 6, February 10, 2025.
Inspired by the structure and reciprocating motion of fish dorsal fins, a drug‐eluting contact lens based on deformable microstructures for non‐invasive drug delivery is developed. The drug release rate can be adaptively adjusted to intraocular pressure changes and proactively regulated by cyclic ocular loads, enabling it to respond to elevated ...
Xu Li, Hui Li, Zihao Wang, Xianda Wang, Jinlong Zhang, Fengjiao Bin, Wei Chen, Hongyang Li, Dongmei Huo, Dengbao Xiao   +9 more
wiley   +1 more source

Observational study for multiparametric assessment of cardiac congestion in outpatient worsening heart failure (EVOLUTION)

European Journal of Heart Failure, Volume 27, Issue 2, Page 325-336, February 2025.
EVOLUTION study findings. KCCQ‐12, 12‐question Kansas City Cardiomyopathy Questionnaire; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide Abstract Aims We sought to characterize the clinical course of patients following worsening heart failure (WHF) treated in an outpatient setting and to identify factors associated with a poor response to standard
Gad Cotter, Beth Davison, Philip Janiak, Christopher Edwards, Maria Novosadova, Koji Takagi, Marie‐Laure Ozoux, Francesca Lawson, Hamlet Hayrapetyan, Hamayak Sisakian, Victor R. Ter‐Grigoryan, Katell Peoc'h, Alexandre Raynor, Paul Bruzeau, Alexis Nguyen, Alexandre Mebazaa   +15 more
wiley   +1 more source

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

, 1996
The multidrug resistance protein MRP has been shown to mediate the transport of glutathione S-conjugates across membranes. In this study we demonstrate that the glutathione S-conjugate of the diuretic drug ethacrynic acid, which is an efficient inhibitor
Cnubben, Nicole H.P., van Bladeren, Peter J., Evers, Raymond, Zaman, Guido J.R., Borst, Piet   +4 more
core   +1 more source

Catalysis of Silver catfish Major Hepatic Glutathione Transferase proceeds via rapid equilibrium sequential random Mechanism

Toxicology Reports, 2016
Fish hepatic glutathione transferases are connected with the elimination of intracellular pollutants and detoxification of organic micro-pollutants in their aquatic ecosystem. The two-substrate steady state kinetic mechanism of Silver catfish (Synodontis
Ayodele O. Kolawole
doaj   +1 more source