Results 51 to 60 of about 2,686,486 (201)
Nanomaterials, 2015 During the chemotherapy of cancer, drug resistance is the first issue that chemotherapeutic drugs cannot be effectively used for the treatment of cancers repeatedly for a long term, and the main reason for this is that tumor cell detoxification is ...
Bing Han +5 more
doaj +1 more source
European Journal of Heart Failure, Volume 27, Issue 12, Page 3123-3133, December 2025.This study investigated the prognostic value of residual congestion phenotypes at discharge in acute heart failure. Patients with intravascular residual congestion had better diuretic responses and shorter hospital stays than those with tissue/combined residual congestion, but worse outcomes than decongested patients.
Daan C.H. Ceelen +15 more
wiley +1 more source
Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management
The FASEB Journal, Volume 39, Issue 21, 15 November 2025.Pulmonary disorders remain a global health challenge. This review explores critical innovations in inhaled nanoparticle drug delivery systems focusing on their potential to revolutionize treatment strategies for a wide spectrum of pulmonary diseases. We highlight recent breakthroughs in carrier materials, performance evaluations in vitro and in vivo ...
Yunzhou Fan +3 more
wiley +1 more source
Relative effects of furosemide and ethacrynic acid on ion transport and energy metabolism in slices of rat kidney-cortex [PDF]
, 1981 The effects of furosemide and ethacrynic acid have been studied using slices of rat kidney cortex incubated in a Ringer medium. At concentrations from 0.2–2.0 mM, furosemide had no significant effect on the tissue ATP content or on the metabolism ...
Rossum, George D. V. +2 more
core +1 more source
, 2022 Yenigul, Munevver/0000-0003-0468-721X; Gencer Akcok, E. Basak/0000-0002-6559-9144; Akcok, Ismail/0000-0002-5444-3929Background Despite the recent advances in chemotherapy, the outcomes and the success of these treatments still remain insufficient.
Gencer Akcok, Emel Basak +2 more
core +1 more source
PLoS Neglected Tropical Diseases, 2023 In the human host, the protozoan parasite Entamoeba histolytica is adapted to a non-invasive lifestyle in the colon as well as to an invasive lifestyle in the mesenterial blood vessels and the liver.
Anna Nagode +5 more
doaj +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 3, September 2025.ABSTRACT Background Congenital hearing loss (CHL) affects approximately 1–2 in 1000 children and significantly impacts development. Exposure to medications during pregnancy may impact offspring hearing; however, the ototoxic effects of different drugs have not been systematically investigated.
Asli Sena Kücükyildiz +6 more
wiley +1 more source
Neurobiology of Disease, 2012 TAR DNA-binding protein 43 (TDP-43) is a major component of ubiquitin-positive inclusion of TDP-43 proteinopathies including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinated inclusions, which is now referred to as ...
Yohei Iguchi +7 more
doaj +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, Volume 292, Issue 17, Page 4675-4693, September 2025.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source
, 1997 The potent diuretic drug ethacrynic acid has been tested in clinical trials as an adjuvant in chemotherapy. Its target is the detoxifying enzyme glutathione transferase which is often found overexpressed in cancer tissues.
CACCURI, ANNA MARIA +15 more
core +1 more source