Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes +7 more
wiley +1 more source
Some effects of insect hormones on Na(^+), K(^+)-ATPase and fluid secretion by the malpighian tubules of locusta migratoria L [PDF]
A study has been made on the effects of insect hormones on fluid secretion by the Malpighian tubules of Locusta, and on the Na(^+), K(^+)- ATPase activity in microsomal preparations of the tubules.
Donkin, Julie Ellison
core
Influence of ethacrynic acid on intrarenal renin release mechanisms
Influence of ethacrynic acid on intrarenal renin release mechanisms. Ethacrynic acid infused i.v. in anesthetized dogs after inhibiting sympathetic mechanisms of renin release increased renal blood flow rate (RBF) by 54% and practically abolished ...
Langård, Øivind +3 more
core +1 more source
Effects of ethacrynic acid on ion transport and energy metabolism in slices of avian salt gland and of mammalian liver and kidney cortex [PDF]
Ethacrynic acid greatly inhibited net transport of ions and aerobic, energyconserving metabolism in slices of avian salt gland, rat liver, and rat and guinea-pig kidney cortex.
Rossum, George D. V., Ernst, Stephen A.
core +1 more source
Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley +1 more source
New EA-sulfonamides and indazole-sulfonamides were synthesized, characterized, and evaluated for their anticancer activities. The target compound structures were elucidated using various spectroscopic techniques such as NMR-{1H and 13C}, infrared ...
Nassima Saghdani +6 more
doaj +1 more source
Biological significance of glutathione S-transferases in human sperm cells
Background: Oxidative stress is considered as one of the causes of male subfertility or infertility. Among antioxidant enzymes, the crucial role belongs to glutathione S-transferases (GSTs).
Roman V Fafula +6 more
doaj +1 more source
Alpha-class glutathione S-transferases in wild turkeys (Meleagris gallopavo): characterization and role in resistance to the carcinogenic mycotoxin aflatoxin B1. [PDF]
Domestic turkeys (Meleagris gallopavo) are one of the most susceptible animals known to the toxic effects of the mycotoxin aflatoxin B1 (AFB1), a potent human hepatocarcinogen, and universal maize contaminant.
Ji Eun Kim +4 more
doaj +1 more source
The vasodilator properties of isoproterenol, diazoxide, ethacrynic acid, and furosemide were compared in the isolated canine gracilis muscle perfused with arterial blood at a constant rate.
R. I. Ogilvie, P. Larochelle, E. Mikulic
core +1 more source
Glutathione transferases (GST) were purified from locally isolated bacteria, Acinetobacter calcoaceticus Y1, by glutathione-affinity chromatography and anion exchange, and their substrate specificities were investigated.
Chin-Soon Chee +2 more
doaj +1 more source

