Results 91 to 100 of about 5,945,207 (220)
, 1985 Glutamine and lactate oxidations provide the bulk of ATP required for sodium reabsorption in the dog kidney during chronic metabolic acidosis. Indirect evidence has suggested that glutamine is oxidized in the proximal convoluted tubule; if this is true,
Ching B. Chen, Mitchell L. Halperin
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Ethacrynic Acid Induced Inotropism
Experimental Biology and Medicine, 1975 Ethacrynic acid (ECA), a sulfhydryl group inhibiting diuretic was examined for positive inotropic effects. These were found to be present in isolated guinea pig left atria studied in 0.9 and 1.8 mM Ca bathing solutions and were partially dependent upon adrenergic mechanisms (presumably secondary to norepinephrine release from sympathetic nerve endings)
A H, From, J L, Probstfield, T R, Smith
openaire +2 more sources
Journal of Cellular and Molecular Medicine, Volume 28, Issue 8, April 2024.Abstract Liver hepatocellular carcinoma (LIHC) is a significant global health issue with limited treatment options. In this study, single‐cell RNA sequencing (scRNA‐seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy.
Yumeng Wang +5 more
wiley +1 more source
, 1983 The experiments concerned the effect of ethacrynic acid (0.5 mM) on the adenosine triphosphate (ATP) content of rat mast cells and the effect on histamine release induced by the ionophore A23187 (10 microM). Ethacrynic acid decreased the ATP level of the
Johansen, Torben
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Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 152-167, February 2024.Abstract Background The antineoplastic drug busulfan can induce different hepatic lesions including cholestasis and sinusoidal obstruction syndrome. However, hepatic steatosis has never been reported in patients. Objectives This study aimed to determine whether busulfan could induce steatosis in primary human hepatocytes (PHH) and differentiated HepaRG
Julien Allard +4 more
wiley +1 more source
Purification and Characterization of Glutathione S-Transferase from rabbit liver [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعيةGlutathione S-transferases (GSTs) are essential enzymes involved in the detoxification process in animals. They catalyze the conjugation of the antioxidant glutathione (GSH) to various electrophilic compounds, such as environmental toxins, carcinogens ...
Abdelrahim A. Hunaiti, Ahmad Al hadidi
doaj +1 more source
Bioorganic & Medicinal Chemistry Letters, 2008 A series of amides of ethacrynic acid was prepared and evaluated for their ability to inhibit Wnt signaling and decrease the survival of CLL cells. Several of the most potent derivatives were active in the low micromolar range.
Guangyi Jin +6 more
semanticscholar +1 more source
Effects of Furosemide and Ethacrynic Acid on Cation Transport Across Phospholipid Bilayer Membranes
, 1974 Phosphatidylcholine vesicles acquire a negative surface charge in the presence of furosemide or ethacrynic acid. In addition, these same vesicles also display a higher efflux rate for 22Na and 86Rb when exposed to these two diuretics.
M. A. Singer
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, 2018 Ethacrynic acid (EA) is a diuretic drug that is widely used to treat high-blood pressure and swelling caused by congestive heart failure or kidney failure.
Tong Song (5220311) +6 more
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REVERSING OF CHLORAMBUCIL RESISTANCE BY ETHACRYNIC-ACID IN A B-CELL PATIENT
, 1993 We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated.
GRASSI B +5 more
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