Results 91 to 100 of about 2,686,486 (201)

Purification and Characterization of Glutathione S-Transferase from rabbit liver [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية
Glutathione S-transferases (GSTs) are essential enzymes involved in the detoxification process in animals. They catalyze the conjugation of the antioxidant glutathione (GSH) to various electrophilic compounds, such as environmental toxins, carcinogens ...
Abdelrahim A. Hunaiti, Ahmad Al hadidi
doaj   +1 more source

Ethacrynic Acid Induced Inotropism

Experimental Biology and Medicine, 1975
Ethacrynic acid (ECA), a sulfhydryl group inhibiting diuretic was examined for positive inotropic effects. These were found to be present in isolated guinea pig left atria studied in 0.9 and 1.8 mM Ca bathing solutions and were partially dependent upon adrenergic mechanisms (presumably secondary to norepinephrine release from sympathetic nerve endings)
A H, From, J L, Probstfield, T R, Smith
openaire   +2 more sources

Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent. [PDF]

Int J Mol Sci, 2023
Yu L, Lee H, Rho SB, Park MK, Lee CH.
europepmc   +1 more source

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

, 1996
The multidrug resistance protein MRP has been shown to mediate the transport of glutathione S-conjugates across membranes. In this study we demonstrate that the glutathione S-conjugate of the diuretic drug ethacrynic acid, which is an efficient inhibitor
Cnubben, N.H.P., Bladeren, P.J. van, Evers, R., Zaman, G.J.R., Borst, P.   +4 more
core  

Effects of Furosemide and Ethacrynic Acid on Cation Transport Across Phospholipid Bilayer Membranes

, 1974
Phosphatidylcholine vesicles acquire a negative surface charge in the presence of furosemide or ethacrynic acid. In addition, these same vesicles also display a higher efflux rate for 22Na and 86Rb when exposed to these two diuretics.
M. A. Singer
core   +1 more source

Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. [PDF]

Protein Cell, 2021
Cui Z, Liu Y, Wan W, Xu Y, Hu Y, Ding M, Dou X, Wang R, Li H, Meng Y, Li W, Jiang W, Li Z, Li Y, Tan M, Ma DK, Ding Y, Liu JO, Luo C, Yu B, Tang Q, Dang Y.   +21 more
europepmc   +1 more source

Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

, 2015
International audienceThe well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like ...
Caminade, A.-M., El brahmi, Nabil, Caron, Joachim, Bousmina, Mosto M., El Kazzouli, S., Cresteil, Thierry, Majoral, Jean Pierre, Mignani, Serge M.   +7 more
core   +1 more source

Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation. [PDF]

Dis Markers, 2021
Zhang X, Huang C, Cui B, Pang Y, Liang R, Luo X.   +5 more
europepmc   +1 more source

Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function

, 2018
Ethacrynic acid (EA) is a diuretic drug that is widely used to treat high-blood pressure and swelling caused by congestive heart failure or kidney failure.
Tong Song (5220311), Zi Ye (302115), Xiaoyun Zhang (115529), Yuangang Zhu (5220314), Xiaowei Chen (200607), Xiaoguang Lei (445201), Chu Wang (62506)   +6 more
core   +2 more sources

Mechanism of ethacrynic acid-induced choleresis in the rat

, 1975
Ethacrynic acid (EA) was injected to rats with functional nephrectomy after a control period of steady-state bile flow sustained by taurocholate infusion.
A Raizman, J Chenderovitch, R Infante
core   +1 more source