Results 111 to 120 of about 2,686,486 (201)

Transport and metabolism of glutathione conjugates of menadione and ethacrynic acid in confluent monolayers of rat renal proximal tubular cells

, 1996
Confluent monolayers of primary rat renal proximal tubular (RPT) cells were used to compare transepithelial transport and concomitant metabolism of two different glutathione (GSH) S-conjugates. For the GSH-conjugated quinone compound, [35S]GSH-conjugated
Bladeren, P.J. van, Spenkelink, A., Haenen, H.E.M.G., Temmink, J.H.M., Koeman, J.H., Teunissen, C.   +5 more
core  

Inhibition of glutathione S-transferase activity in human melanoma cells by alfa, beta-unsaturated carbonyl derivatives : effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal

, 1996
The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione ...
Bladeren, P.J. van, Amersfoort, C. van, Struik, I., Schefferlie, J.G., Ploemen, J.P.H.T.M., Keyzer, A.E., Iersel, M.L.P.S. van   +6 more
core  

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic Acid-Modified Ligands

, 2016
Pyridine- and phosphine-based ligands modified with ethacrynic acid (EA, i.e. a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes.1 All the compounds (ligands and complexes) were fully ...
Biancalana, L., Zacchini, S., ZACCHINI, STEFANO, Chiellini, F., Dyson, P. J., Gabbiani, C., AGONIGI, GABRIELE, GABBIANI, CHIARA, Dyson, Paul J., PAMPALONI, GUIDO, Pampaloni, G., CHIELLINI, FEDERICA, Riedel, T., Marchetti, F., Agonigi, G., FUNAIOLI, TIZIANA, MARCHETTI, FABIO, BIANCALANA, LORENZO, Funaioli, T.   +18 more
core  

Utilizing ethacrynic acid and ciclopirox olamine in liver cancer. [PDF]

Oncol Lett, 2018
Al-Dali AM, Weiher H, Schmidt-Wolf IGH.
europepmc   +1 more source

Studies on ATPase activity of rat kidney microsomal fraction.

, 1971
The effects of ethacrynic acid, furosemide and ouabain on ATPase activity of rat microsomal fraction were studied in order to confirm the evidence of relation between effect on ATPase activity and their diuretic action. Ethacrynic acid and furosemide
오진설, 박찬웅, 문익주
core  

Ethacrynic Acid Mitigates Skin Fibrosis through Downregulation of S100 Family Damage-Associated Molecular Pattern Expression in the Epidermis. [PDF]

J Invest Dermatol
Dolivo DM, Rodrigues AE, Mustoe TA, Galiano RD, Hong SJ.   +4 more
europepmc   +1 more source

Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1

, 1994
The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an α,β-unsaturated ketone, with glutathione and glutathione S-transferase P1-1 (GST P1-1) has been studied. When the glutathione conjugate of EA was incubated with a
Bladeren, P.J. van, Ploemen, J.H.T.M., Schanke, A. van, Ommen, B. van   +3 more
core  

Identification of Boc₂Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. [PDF]

ACS Med Chem Lett
Sun H, Wang C, Li X, Lü Z, Li K, Hu H, Xu P, Xiao Y, Niu Y.   +8 more
europepmc   +1 more source

Ethacrynic Acid continuous infusions in critically ill pediatric patients. [PDF]

J Pediatr Pharmacol Ther, 2014
Miller JL, Schaefer J, Tam M, Harrison DL, Johnson PN.   +4 more
europepmc   +1 more source

Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer. [PDF]

Oncotarget, 2016
Liu B, Huang X, Hu Y, Chen T, Peng B, Gao N, Jin Z, Jia T, Zhang N, Wang Z, Jin G.   +10 more
europepmc   +1 more source