Results 1 to 10 of about 173,316,258 (215)
Olfactomedin 4 as a novel loop of Henle‐specific acute kidney injury biomarker [PDF]
Physiological Reports, 2022 Acute kidney injury (AKI) is associated with morbidity and mortality. Urinary biomarkers may disentangle its clinical heterogeneity. Olfactomedin 4 (OLFM4) is a secreted glycoprotein expressed in stressed neutrophils and epithelial cells. In septic mice,
Denise C. Hasson +7 more
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UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study. [PDF]
Clin Pharmacol TherUromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Kreutz R +5 more
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Loop tubulopathies: Bartter’s syndrome [PDF]
Педиатрическая фармакология, 2019 The authors provide a review of current clinical guidelines regarding medical care provided to children with Bartter’s syndrome — impaired renal tubular function (loop of Henle) with the development of hypokalemia, hypochloremia, metabolic alkalosis and ...
Alexander A. Baranov +15 more
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A Rare Case of Bartter Syndrome Type 3 Diagnosed in Elderly Age [PDF]
Case Reports in EndocrinologyBartter syndrome (BS) type 3 typically presents in childhood and is caused by defects in NaCl transporters of the thick ascending limb of the loop of Henle.
Tsuyoshi Okura +5 more
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Axial nephron fate switching demonstrates a plastic system tunable on demand [PDF]
Nature CommunicationsThe human nephron is a highly patterned tubular structure that develops specialized cells to regulate bodily fluid homeostasis, blood pressure, and urine secretion throughout life. Approximately 1 million nephrons form in each kidney during embryonic and
MaryAnne A. Achieng +7 more
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Hereditary kidney diseases associated with hypomagnesemia [PDF]
Kidney Research and Clinical Practice, 2021 In the kidney, a set of proteins expressed in the epithelial cells of the thick ascending loop of Henle and the distal convoluted tubule directly or indirectly play important roles in the regulation of serum magnesium levels.
Felix Claverie-Martin +2 more
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Antibiotics, 2021 Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated.
Martin Scoglio +10 more
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Neonatal Bartter syndrome: A case report from Northern India
Український Журнал Нефрології та Діалізу, 2021 . Bartter Syndrome is a rare genetic disorder affecting the renal tubular system causing a decreased absorption of sodium and chloride in the thick ascending limb of the Henle loop. Most children present in infancy with complaints of polyuria, polydipsia,
Astitva Singh +4 more
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Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. [PDF]
PLoS ONE, 2016 The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied ...
Michael C Stankewich +4 more
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Physiology and pathophysiology of ClC-K/barttin channels
Frontiers in Physiology, 2010 ClC-K channels form a subgroup of anion channels within the ClC family of anion transport proteins. They are expressed predominantly in the kidney and in the inner ear, and are necessary for NaCl resorption in the loop of Henle and for K+ secretion by ...
Christoph eFahlke, Martin eFischer
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