Results 31 to 40 of about 8,432 (181)
Uromodulin — Biological Significance and Prospects for Clinical Use
Архивъ внутренней медицины, 2023 Uromodulin is a unique protein produced in the kidneys by epithelial cells of the ascending thick portion of the loop of Henle. It implements physiological mechanisms not only at the tubular level, but also participates in the coordination of general ...
E. S. Levitskaya +2 more
doaj +1 more source
An Interdisciplinary Review of the Gaslighting Literature and Future Research Agenda
Journal of Organizational Behavior, EarlyView.ABSTRACT Gaslighting is increasingly discussed in organizational contexts, yet its meaning, boundaries, and process remain unclear within management and organizational scholarship. Although research on gaslighting has expanded across multiple disciplines, existing work is conceptually fragmented and difficult to integrate, limiting cumulative theory ...
Paula A. Kincaid, Samantha C. O. Stalion
wiley +1 more source
Active Osmotic Exchanger for Efficient Nanofiltration Inspired by the Kidney
Physical Review X, 2016 In this paper, we investigate the physical mechanisms underlying one of the most efficient filtration devices: the kidney. Building on a minimal model of the Henle loop—the central part of the kidney filtration—we investigate theoretically the detailed ...
Sophie Marbach, Lydéric Bocquet
doaj +1 more source
Pediatric Discovery, EarlyView.MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen +11 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida +7 more
wiley +1 more source
Primary Molecular Disorders and Secondary Biological Adaptations in Bartter Syndrome
International Journal of Nephrology, 2011 Bartter syndrome is a hereditary disorder that has been characterized by the association of hypokalemia, alkalosis, and the hypertrophy of the juxtaglomerular complex with secondary hyperaldosteronism and normal blood pressure.
Georges Deschênes, Marc Fila
doaj +1 more source
The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes
Diabetic Medicine, EarlyView.Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald +13 more
wiley +1 more source
Understanding Exosomes in Hair Regeneration
Periodontology 2000, EarlyView.Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad +3 more
wiley +1 more source
NefrologíaResumen: La rama gruesa ascendente del asa de Henle (TAL) reabsorbe aproximadamente el 30% de NaCl filtrado mediante 2 mecanismos: reabsorción transepitelial y paracelular.
Susana Enrique Madrid +1 more
doaj +1 more source
African Journal of Urology, 2014 Kidney stones have probably affected mankind for ages with early reports in an Egyptian mummy. While prevalence of stone disease is increasing, its pathogenesis remains elusive.
N. Abrol, N.S. Kekre
doaj +1 more source