Results 11 to 20 of about 16,687 (224)

Thick ascending limb of the loop of Henle. [PDF]

Clin J Am Soc Nephrol, 2014
The thick ascending limb occupies a central anatomic and functional position in human renal physiology, with critical roles in the defense of the extracellular fluid volume, the urinary concentrating mechanism, calcium and magnesium homeostasis, bicarbonate and ammonium homeostasis, and urinary protein composition.
Mount DB.
europepmc   +4 more sources

Signal transduction in a compliant short loop of Henle. [PDF]

Int J Numer Method Biomed Eng, 2012
SUMMARYTo study the transformation of fluctuations in filtration rate into tubular fluid chloride concentration oscillations alongside the macula densa, we have developed a mathematical model for tubuloglomerular feedback (TGF) signal transduction along the pars recta, the descending limb, and the thick ascending limb (TAL) of a short‐looped nephron ...
Layton AT, Pham P, Ryu H.
europepmc   +5 more sources

Adult-Onset Bartter Syndrome Presenting as Refractory Hypokalemia and Metabolic Alkalosis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Bartter syndrome (BS) is a rare autosomal recessive salt‐wasting tubulopathy characterized by hypokalemic metabolic alkalosis, hyperreninemia, and hyperaldosteronism without hypertension. It usually presents in childhood; however, adult‐onset cases are infrequent and often misdiagnosed.
Asif M, Sanam A, Ilyas M, Tahir S, Hanif T, Khalid M, Sarwar I, Segawa F.   +7 more
europepmc   +2 more sources

Physiology and pathophysiology of ClC-K/barttin channels

Frontiers in Physiology, 2010
ClC-K channels form a subgroup of anion channels within the ClC family of anion transport proteins. They are expressed predominantly in the kidney and in the inner ear, and are necessary for NaCl resorption in the loop of Henle and for K+ secretion by ...
Christoph eFahlke, Martin eFischer
doaj   +1 more source

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y., Beach R.E., Biondi M., Burnstock G., Casellas D., Cohen H.J., Edwards R.M., Guan Z., Harrison‐Bernard L.M., Harrison‐Bernard L.M., Jamison R.L., Kreisberg M.S., Kriz W., Larson T.S., Lazarowski E.R., Lerman L.O., Majid D.S., Pallone T.L., Rouget C., Seldin D.W., Stern M.D., Strick D.M., Takenaka T., Takezawa K., Turner M.R., Unwin R.J., Yamagishi S., Yang S.   +27 more
core   +1 more source

Loop tubulopathies: Bartter’s syndrome

Педиатрическая фармакология, 2019
The authors provide a review of current clinical guidelines regarding medical care provided to children with Bartter’s syndrome — impaired renal tubular function (loop of Henle) with the development of hypokalemia, hypochloremia, metabolic alkalosis and ...
Alexander A. Baranov, Leyla S. Namazova-Baranova, Tatyana V. Sergeeva, Olga V. Chumakova, Svetlana S. Paunova, Nurali Z. Zokirov, Olga V. Komarova, Tea V. Margieva, Vladimir K. Tatochenko, Maya D. Bakradze, Elena N. Tsygina, Olga I. Zrobok, Tatiana V. Vashurina, Irina N. Lupan, Mikhail Yu. Kagan, Alexey N. Tsygin   +15 more
doaj   +1 more source

New Strategies for Volume Control in Patients with Diabetes Mellitus, a Narrative Review

Pharmaceutics, 2022
Sodium is reabsorbed all along the renal tubules. The positive impacts of sodium-glucose cotransporter-2 inhibitors (SGLT2i), angiotensin receptor neprilysin inhibitor (ARNI) and mineralocorticoid receptor antagonists (MRA) on hard renal and/or cardiac ...
Alexandre O. Gérard, Audrey Laurain, Antoine Sicard, Diane Merino, Atul Pathak, Milou-Daniel Drici, Guillaume Favre, Vincent L. M. Esnault   +7 more
doaj   +1 more source

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes, B Mann, B Rose, B Rose, B Rose, CM Hao, DA Heller, DO Stichtenoth, F Catella-Lawson, F Nantel, G Giovanni, H Syme, H. Syme, J Hippisley-Cox, J Peti-Peterdi, J. Elliott, J. N. King, JA Jakobsen, K Schumacher, K. Smith, KA Kirchner, KL Therland, KN Khan, KN Khan, L Pelligand, L Pelligand, L. Pelligand, M Komhoff, M Meskell, M Sabbatini, N. Suemanotham, P. Lees, PA Friedman, RC Harris, RC Harris, RE Jepson, S Yu, V Campean, V Sreenivasan, VB Schmid, W. Seewald, WA Corsini, XR He   +42 more
core   +3 more sources

Function of thin loops of Henle

Kidney International, 1987
The existence of a steep osmotic gradient in the renal medullary interstitium is the most critical in the formation of concentrated urine [1]. The architectural organization of the renal tubules and blood vessels in the medulla constitutes counterflow systems which are essential for both generating and maintaining high osmotic pressure of the renal ...
Imai, Masashi, Taniguchi, Junichi, Tabei, Kaoru   +2 more
openaire   +2 more sources

Role of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney Development. [PDF]

PLoS ONE, 2015
The homeobox transcription factor Prox1 is critical to the development of many embryonic organs and tissues, although current understanding of its expression in the developing renal medulla is limited.
Yu-Mi Kim, Wan-Young Kim, Sun Ah Nam, A-Rum Choi, Hyang Kim, Yong-Kyun Kim, Hak-Soo Kim, Jin Kim   +7 more
doaj   +1 more source