Results 11 to 20 of about 633,245 (221)

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study. [PDF]

Clin Pharmacol Ther
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Kreutz R, Gebert P, Luo J, Tassopoulou P, Bolbrinker J, Douros A.   +5 more
europepmc   +2 more sources

Systematic Review and Meta-Analysis of the Effect of Loop Diuretics on Antibiotic Pharmacokinetics. [PDF]

Pharmaceutics, 2023
Loop diuretics and antibiotics are commonly co-prescribed across many clinical care settings. Loop diuretics may alter antibiotic pharmacokinetics (PK) via several potential drug interactions.
Kerling DA, Clarke SC, DeLuca JP, Evans MO, Kress AT, Nadeau RJ, Selig DJ.   +6 more
europepmc   +2 more sources

Clinical Pharmacology of Loop Diuretics in Critical Care. [PDF]

Clin Pharmacokinet
Loop diuretics are a cornerstone in the management of fluid overload in critically ill patients; however, their use is often complicated by variable pharmacokinetics and the phenomenon of diuretic resistance.
Ferrari F, Zanza C, Tesauro M, Longhitano Y, Planinsic R, Voza A, Fumagalli J, Scaravilli V, Grasselli G.   +8 more
europepmc   +2 more sources

Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study. [PDF]

J Clin Med, 2022
Background: The association between loop diuretics and acute kidney injury (AKI) remains unclear. Methods: The population studied was selected from the Epidemiology of AKI in Chinese Hospitalized patients (EACH) study.
Zhou L, Li Y, Gao Q, Lin Y, Su L, Chen R, Cao Y, Xu R, Luo F, Gao P, Zhang X, Li P, Nie S, Tang Y, Xu X, On Behalf Of The Each Study Investigators.   +15 more
europepmc   +2 more sources

Sensitivity analysis excluding patients treated with loop diuretics.

, 2022
A-B. Change in estimated effect between estimated 24-hour sodium urinary excretion and vascular events (A) and mortality (B) after exclusion of patients who were treated with loop diuretics (dashed blue line). Black lines depict the main analysis.
Eline H. Groenland (12256701), Hendrik M. Nathoe (11409984), Frank L. J. Visseren (8445648), Wilko Spiering (590722), Michiel L. Bots (7464287), Ynte M. Ruigrok (9199566), Peter J. Blankestijn (8783285), Jean-Paul Vendeville (12256704), Gert Jan de Borst (12256707)   +8 more
core   +1 more source

Diuretics — a review of the current knowledge

, 2023
Diuretics are drugs that increase diuresis and natriuresis. Diuretics reduce sodium reabsorption in the proximal tubule (SGLT2 inhibitors, carbonic anhydrase inhibitors), the loop of Henle (loop diuretics), the distal tubule (thiazide and thiazide-like ...
Więcek, Andrzej; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Surma, Stanisław; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Adamczak, Marcin; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice   +2 more
core   +1 more source

Continuous infusion versus bolus injection of loop diuretics for congestive heart failure [PDF]

, 2021
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of intravenous continuous infusion versus bolus injection of loop diuretics for the initial treatment of acute decompensated heart ...
Fernando, R, Lip, Gregory YH, Farnell, E, Hill, RA, Tsangarides, Andreas, Zhang, Juqian, Farnell, Ebony, Fernando, Ranga, Tsangarides, A, Ahmed, Sarah, Ihsan, Mahnoor, Sankaranarayanan, R, Sankaranarayanan, Rajiv, Zhou, C, Ahmed, S, Surtee, Shazmeen, Hill, Ruaraidh A, Lwin, TS, Chaudhary, M, Lip, GYH, Chaudhary, Muhammad, Lwin, Tin Sanda, Surtee, S, Zhou, Can, Ihsan, M, Zhang, J, Muhammad Chaudhary, Shazmeen Surtee, Rajiv Sankaranarayanan, Juqian Zhang, Tin Sanda Lwin, Andreas Tsangarides, Ebony Farnell, Gregory YH Lip, Sarah Ahmed, Can Zhou, Mahnoor Ihsan, Ranga Fernando, Ruaraidh A Hill   +38 more
core   +1 more source

Impact of Loop Diuretics on Long-Term Kidney Outcome: A Post Hoc Analysis of the STOP-Angiotensin-Converting Enzyme Inhibitor Trial. [PDF]

Kidney360
Background: In the STOP-ACEi trial, patients with advanced CKD were randomised to continue or stop renin–angiotensin system inhibitors (RASi) and showed no difference in kidney outcomes. This post-hoc analysis investigates interactions with loop diuretic
Bhandari S, Mehta S, Ives N, Cleland JGF, Cockwell P.   +4 more
europepmc   +3 more sources

Use of piretanide, a new loop diuretic in cirrhosis with ascites. Relationship between the diuretic response and the plasma aldosterone level [PDF]

, 1980
Twenty patients with cirrhosis and ascites but no renal failure were given piretanide, a new loop diuretic, in order to investigate its efficacy and to relate the diuretic response with the pretreatment plasma aldosterone concentration.
Rivera Fillat, Francisca, Rodés, J., Arroyo, Vicente, Casamitjana i Abellà, Roser, Cabrera, J., Bosch i Genover, Jaume   +5 more
core   +1 more source

A retrospective study of 14 dogs with advanced heart failure treated with loop diuretics and hydrochlorothiazide. [PDF]

Open Vet J, 2021
Background: The use of thiazide diuretics is recommended in the American College of Veterinary Internal Medicine guidelines for advanced heart failure due to mitral insufficiency (MI) in dogs.
Iwanaga K, Araki R, Isaka M.
europepmc   +3 more sources