Results 1 to 10 of about 10,959 (212)

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme

Pharmaceuticals, 2020
The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers. Being undetected in most normal tissues, hCA-IX implies the pharmacotherapeutic advent of reduced
Azizah M. Malebari, Tarek S. Ibrahim, Ibrahim M. Salem, Ismail Salama, Ahdab N. Khayyat, Samia M. Mostafa, Osama I. El-Sabbagh, Khaled M. Darwish   +7 more
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Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function

Frontiers in Neurology, 2020
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu, Ru Liu, Ru Liu, Ru Liu, Junling Wang, Junling Wang, Junling Wang, Junling Wang, Shuli Liang, Guojun Zhang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +13 more
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Longitudinal Effects of Bumetanide on Neuro-Cognitive Functioning in Drug-Resistant Epilepsy

Frontiers in Neurology, 2019
Antiepileptic drugs (AEDs) have repeatedly shown inconsistent and almost contradictory effects on the neurocognitive system, from substantial impairments in processing speed to the noticeable improvement in working memory and executive functioning ...
Zeinab Gharaylou, Lida Shafaghi, Mohammad Ali Oghabian, Ali Yoonessi, Abbas Tafakhori, Esmaeil Shahsavand Ananloo, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +7 more
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Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Frontiers in Physiology, 2020
Introduction: Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl− homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response to ...
Lanxin Luo, Lanxin Luo, Jun Wang, Jun Wang, Dawei Ding, Dawei Ding, Md Nabiul Hasan, Sung-Sen Yang, Shih-Hua Lin, Philipp Schreppel, Baoshan Sun, Yan Yin, Thomas Erker, Dandan Sun, Dandan Sun   +14 more
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Asthmatic Airway Vagal Hypertonia Involves Chloride Dyshomeostasis of Preganglionic Neurons in Rats

Frontiers in Neuroscience, 2020
Airway vagal hypertonia is closely related to the severity of asthma; however, the mechanisms of its genesis are unclear. This study aims to prove that asthmatic airway vagal hypertonia involves neuronal Cl– dyshomeostasis.
Ding He, Hong Chen, Ming Zeng, Chunmei Xia, Jin Wang, Linlin Shen, Danian Zhu, Yonghua Chen, Jijiang Wang   +8 more
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Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior

Frontiers in Molecular Neuroscience, 2019
Brain trauma triggers a cascade of deleterious events leading to enhanced incidence of drug resistant epilepsies, depression, and cognitive dysfunctions.
Emmanuelle Goubert, Marc Altvater, Marie-Noelle Rovira, Ilgam Khalilov, Ilgam Khalilov, Morgane Mazzarino, Anne Sebastiani, Michael K. E. Schaefer, Claudio Rivera, Claudio Rivera, Christophe Pellegrino   +10 more
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Dynamic Functional Network Connectivity Analysis in Autism Spectrum Disorder: An EEG Study

IEEE Access
Convergent evidence has suggested a significant effect of bumetanide exposure on brain connectivity in patients with autism spectrum disorder (ASD), yet the characteristics of favorable treatment outcome remains largely unknown. In this work, we aimed to
Seyedeh Negin Seyed Fakhari, Foad Ghaderi, Mehdi Tehrani-Doost, Nasrollah Moghadam Charkari   +3 more
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Bumetanide for autism spectrum disorder: Current evidence (eng)

Klinik Psikiyatri Dergisi, 2020
-No abstract is available since it is structured as a "Letter to the Editor".
Mazlum Çöpür, Sidar Copur
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Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. [PDF]

PLoS ONE, 2012
A number of antiepileptic medications that modulate GABA(A) mediated synaptic transmission are anxiolytic. The loop diuretics furosemide (Lasix) and bumetanide (Bumex) are thought to have antiepileptic properties.
Andrew D Krystal, Janice Sutherland, Daryl W Hochman   +2 more
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Effect of Co-administration of Bumetanide and Phenobarbital on Seizure Attacks in Temporal Lobe Epilepsy

Basic and Clinical Neuroscience, 2018
Introduction: The resistance of temporal lobe epilepsy to classic drugs is thought to be due to disruption in the excitation/inhibition of this pathway.
Reza Rahmanzadeh, Soraya Mehrabi, Mahmood Barati, Milad Ahmadi, Fereshteh Golab, Sareh Kazmi, Mohammad Taghi Joghataei, Morteza Seifi, Mazaher Gholipourmalekabadi   +8 more
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