Results 11 to 20 of about 5,998 (173)

Not All Leg Swelling Is Volume Overload: Point-of-Care Ultrasound and Sirolimus-Associated Lymphedema After Combined Heart-Kidney Transplant. [PDF]

Clin Case Rep
Multi‐organ point‐of‐care ultrasound in a combined heart‐kidney transplant recipient with refractory leg edema demonstrated bilateral A‐lines, a collapsible inferior vena cava, and preserved biventricular function, excluding cardiogenic congestion. Right heart catheterization confirmed a low‐filling‐pressure, high‐output state.
Boyle R, Patel N.
europepmc   +2 more sources

Interaction Between the Sodium‐Glucose–Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal Human Subjects

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDapagliflozin inhibits the sodium‐glucose–linked transporter 2 in the renal proximal tubule, thereby promoting glycosuria to reduce hyperglycemia in type 2 diabetes mellitus. Because these patients may require loop diuretics, and sodium‐glucose–
Christopher S. Wilcox, Wen Shen, David W. Boulton, Bruce R. Leslie, Steven C. Griffen   +4 more
doaj   +1 more source

Beta-Amyloid (Aβ_1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus

Molecules, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief.
Patricia Lam, Chitra Vinnakota, Beatriz Calvo-Flores Guzmán, Julia Newland, Katie Peppercorn, Warren P. Tate, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky   +8 more
doaj   +1 more source

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Nature Communications, 2022
Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al.
Yongxiang Zhao, Kasturi Roy, Pietro Vidossich, Laura Cancedda, Marco De Vivo, Biff Forbush, Erhu Cao   +6 more
doaj   +1 more source

A Wholistic View of How Bumetanide Attenuates Autism Spectrum Disorders

Cells, 2022
The specific NKCC1 cotransporter antagonist, bumetanide, attenuates the severity of Autism Spectrum Disorders (ASD), and many neurodevelopmental or neurodegenerative disorders in animal models and clinical trials.
Eric Delpire, Yehezkel Ben-Ari
doaj   +1 more source

Loop Diuretics Inhibit Ischemia-Induced Intracellular Ca2+ Overload in Neurons via the Inhibition of Voltage-Gated Ca2+ and Na+ Channels

Frontiers in Pharmacology, 2021
One consequence of ischemic stroke is disruption of intracellular ionic homeostasis. Intracellular overload of both Na+ and Ca2+ has been linked to neuronal death in this pathophysiological state.
Christopher Katnik, Javier Cuevas
doaj   +1 more source

Failure of bumetanide to improve outcome after intracerebral hemorrhage in rat.

PLoS ONE, 2019
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function ...
Cassandra M Wilkinson, Brittany A Fedor, Jasmine R Aziz, Colby A Nadeau, Paul S Brar, Julia J A Clark, Frederick Colbourne   +6 more
doaj   +1 more source

Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways

Frontiers in Immunology, 2018
Background: The expression of Na-K-2Cl cotransporter 1 (NKCC1) in the alveolar epithelium is responsible for fluid homeostasis in acute lung injury (ALI). Increasing evidence suggests that NKCC1 is associated with inflammation in ALI.
Chih-Hao Shen, Chih-Hao Shen, Chih-Hao Shen, Jr-Yu Lin, Yung-Lung Chang, Shu-Yu Wu, Chung-Kan Peng, Chin-Pyng Wu, Kun-Lun Huang, Kun-Lun Huang   +9 more
doaj   +1 more source

Inhibition of NKCC1 attenuated hippocampal LTP formation and inhibitory avoidance in rat.

PLoS ONE, 2014
The loop diuretic bumetanide (Bumex) is thought to have antiepileptic properties via modulate GABAA mediated signaling through their antagonism of cation-chloride cotransporters.
Meng Chang Ko, Min Chong Lee, Tamara G Amstislavskaya, Maria A Tikhonova, Yi-Ling Yang, Kwok-Tung Lu   +5 more
doaj   +1 more source

Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats

Frontiers in Pharmacology, 2022
Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride.
Shiva Hashemizadeh, Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini ravandi, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +9 more
doaj   +1 more source