Results 11 to 20 of about 10,959 (212)
Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. [PDF]
PLoS ONE, 2013 Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(-) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA ...
Ryan T Cleary +11 more
doaj +4 more sources
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer’s disease
Frontiers in Pharmacology, 2023 Therapeutics discovery and development for Alzheimer’s disease (AD) has been an area of intense research to alleviate memory loss and the underlying pathogenic processes.
Ben Boyarko +16 more
doaj +1 more source
Bumetanide for autism spectrum disorders: A systematic review and meta-analysis
National Journal of Physiology, Pharmacy and Pharmacology, 2022 Background: Autism spectrum disorders (ASD) is diagnosed primarily by the presence of impaired social interaction, social communication, and stereotypical behaviors.
Sharanabasayyaswamy Basayya Hiremath +1 more
doaj +1 more source
Loop diuretics association with Alzheimer’s disease risk
Frontiers in Aging, 2023 Objectives: To investigate whether exposure history to two common loop diuretics, bumetanide and furosemide, affects the risk of developing Alzheimer’s disease (AD) after accounting for socioeconomic status and congestive heart failure.Methods ...
Anna Graber-Naidich +7 more
doaj +1 more source
Frontiers in Immunology, 2022 Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with few medication options. Bumetanide, an FDA-approved diuretic, has been proposed as a viable candidate to treat core symptoms of ASD, however, neither the brain region related ...
Hui Lv +10 more
doaj +1 more source
Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett Syndrome [PDF]
, 2013 Objective: Rett Syndrome is a progressive neurodevelopmental disorder caused mainly by mutations in the gene encoding methyl-CpG-binding protein 2. The relevance of MeCP2 for GABAergic function was previously documented in animal models. In these models,
Armstrong, Judith +11 more
core +7 more sources
Decreased Immunoreactivities and Functions of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Circling Mice [PDF]
Clinical and Experimental Otorhinolaryngology, 2011 ObjectivesWe tested the possibility of differential expression and function of the potassium-chloride (KCC2) and sodium-potassium-2 chloride (NKCC1) co-transporters in the lateral superior olive (LSO) of heterozygous (+/cir) or homozygous (cir/cir) mice ...
Jonu Pradhan +4 more
doaj +1 more source
BUMETANIDE IN AUTISM SPECTRUM DISORDER
Arquivos de Ciências da Saúde da UNIPAR, 2022 Objectives: This study aimed to make a bibliographic update on the already published data on bumetanide, addressing the main information on its use in Autism Spectrum Disorder (ASD).
Lucas da Silva Moreira +1 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Background: The therapeutic effect of bumetanide on autism spectrum disorder (ASD) seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a systematic review and meta-analysis were performed.Methods: Randomized, placebo ...
Tiantian Wang +4 more
doaj +1 more source
Translational Psychiatry, 2022 Bumetanide, a drug being studied in autism spectrum disorder (ASD) may act to restore gamma-aminobutyric acid (GABA) function, which may be modulated by the immune system. However, the interaction between bumetanide and the immune system remains unclear.
Qingyang Li +11 more
doaj +1 more source