Results 11 to 20 of about 8,274 (202)

Bumetanide for autism spectrum disorder: Current evidence (eng)

Klinik Psikiyatri Dergisi, 2020
-No abstract is available since it is structured as a "Letter to the Editor".
Mazlum Çöpür, Sidar Copur
doaj   +2 more sources

The Pharmacokinetics And Pharmacodynamics Of Bumetanide (diuretics).

, 1985
Bumetanide is a potent loop diuretic that acts at the thick ascending limb of the loop of Henle where it inhibits solute reabsorption. Since bumetanide is highly bound to proteins, the drug gains access to the kidney lumen predominantly at the pars recta
Lau, Henry San Heng
core   +6 more sources

Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease [PDF]

, 2021
The evident genetic, pathological, and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-related AD.
Jones, Emily A. Aery, Hao, Yanxia, Jones, Aery, Huang, Yadong, Chang, William, William Chang, William, Yoon, Seo Yeon, Zalocusky, Kelly A, Choudhary, Krishna, Pineda, Silvia, Zalocusky, Kelly A., Paranjpe, Ishan, Oskotsky, Tomiko, Jones, Emily A Aery, Alice Taubes, Alice, Zilberter, Misha Y., Glicksberg, Benjamin S., Grone, Brian, De Freitas, Jessica, Balestra, Maureen E, Wang, Celine, Nova, Phil, An, Alice, Balestra, Maureen E., Chen, Bin, Grone, Brian, Taubes, Alice, Chen, Nuo, Koutsodendris, Nicole, Pineda Sanjuan, Silvia, Chaudhry, Fayzan, Kosti, Idit, Zilberter, Misha Y, Bin Chen, Emily A., Bicak, Mesude, Sirota, Marina, Glicksberg, Benjamin S   +36 more
core   +1 more source

Acute Diuretic Tolerance to Bumetanide.

, 1987
It has been reported that an acute tolerance developed to furosemide diuresis in rats and humans within a short period of time and in an unpredictable manner.
Cook, Jack Alan
core   +5 more sources

Dose Response of Bumetanide on Aquaporins and Angiogenesis Biomarkers in Human Retinal Endothelial Cells Exposed to Intermittent Hypoxia

Pharmaceuticals, 2021
Aquaporins (AQPs) are important for regulating cellular water, solute transport, and balance. Recently, AQPs have also been recognized as playing a key role in cell migration and angiogenesis.
Sibel Guzel, Charles L. Cai, Jacob V. Aranda, Kay D. Beharry   +3 more
doaj   +1 more source

Bumetanide attenuates sevoflurane‐induced neuroapoptosis in the developing dentate gyrus and impaired behavior in the contextual fear discrimination learning test

Brain and Behavior, 2022
Introduction Sevoflurane acts as a gamma‐aminobutyric acid subtype A receptor agonist and can induce widespread apoptosis of immature dentate granule cells in postnatal day 21 mice.
Kai Wei, Yiheng Liu, Xiamin Yang, Jin Liu, Yuan Li, Meng Deng, Yingwei Wang   +6 more
doaj   +1 more source

Interaction Between the Sodium‐Glucose–Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal Human Subjects

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDapagliflozin inhibits the sodium‐glucose–linked transporter 2 in the renal proximal tubule, thereby promoting glycosuria to reduce hyperglycemia in type 2 diabetes mellitus. Because these patients may require loop diuretics, and sodium‐glucose–
Christopher S. Wilcox, Wen Shen, David W. Boulton, Bruce R. Leslie, Steven C. Griffen   +4 more
doaj   +1 more source

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Nature Communications, 2022
Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al.
Yongxiang Zhao, Kasturi Roy, Pietro Vidossich, Laura Cancedda, Marco De Vivo, Biff Forbush, Erhu Cao   +6 more
doaj   +1 more source

Beta-Amyloid (Aβ_1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus

Molecules, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief.
Patricia Lam, Chitra Vinnakota, Beatriz Calvo-Flores Guzmán, Julia Newland, Katie Peppercorn, Warren P. Tate, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky   +8 more
doaj   +1 more source

A Wholistic View of How Bumetanide Attenuates Autism Spectrum Disorders

Cells, 2022
The specific NKCC1 cotransporter antagonist, bumetanide, attenuates the severity of Autism Spectrum Disorders (ASD), and many neurodevelopmental or neurodegenerative disorders in animal models and clinical trials.
Eric Delpire, Yehezkel Ben-Ari
doaj   +1 more source