Loss of NKCC1 Activates the NLRP3 Inflammasome in Intestinal EpitheliaSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Potassium and chloride efflux have been reported to regulate nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.
Rainelli B. Koumangoye +4 more
doaj +2 more sources
EBioMedicine, 2017 Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. The mechanisms that confer GBM cells their invasive behavior are poorly understood.
Paula Schiapparelli +2 more
exaly +3 more sources
NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data
Cells, 2020 Ionotropic GABA transmission is mediated by anion (mainly Cl−)-permeable GABAA receptors (GABAARs). In immature neurons, GABA exerts depolarizing and sometimes functionally excitatory actions, based on active uptake of Cl− by the Na-K-2Cl cotransporter ...
Mari A Virtanen +2 more
exaly +3 more sources
The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice [PDF]
Data in Brief, 2016 K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative diseases.
Takao Tsukahara +4 more
doaj +3 more sources
Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
Frontiers in Neurology, 2020 As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Guojun Zhang, Xiaofeng Yang
exaly +3 more sources
Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain [PDF]
Acta Neuropathologica CommunicationsTraumatic brain injury (TBI) is a leading cause of morbidity and mortality in infants and toddlers, with limited treatment options and persistent neurological sequelae.
Alexandra Hochstetler +11 more
doaj +2 more sources
Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett Syndrome [PDF]
, 2013 Objective: Rett Syndrome is a progressive neurodevelopmental disorder caused mainly by mutations in the gene encoding methyl-CpG-binding protein 2. The relevance of MeCP2 for GABAergic function was previously documented in animal models. In these models,
Armstrong, Judith +11 more
core +26 more sources
Neonatal sevoflurane exposure enhances stress-related neurological susceptibility via NKCC1 modulation [PDF]
Scientific ReportsNeonatal exposure to sevoflurane has been associated with neurodevelopmental impairments. However, the mechanisms underlying increased susceptibility to stress-related neurological disorders remain unclear.
Bi-ying Yuan +5 more
doaj +2 more sources
Structural basis for human NKCC1 inhibition by loop diuretic drugs [PDF]
The EMBO JournalNa+–K+–Cl− cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are
Yongxiang Zhao +6 more
doaj +2 more sources
NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas [PDF]
PeerJ, 2020 Background Gliomas are the most prevalent type of intracranial tumors. NKCC1 is an important regulator in tumor cell volume. We noticed that abnormally high NKCC1 expression resulted in changes in the shape and adhesion of glioma cells.
Huaiyu Sun +4 more
doaj +2 more sources