Results 1 to 10 of about 8,301 (197)

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function [PDF]

Frontiers in Neurology, 2020
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Shuli Liang, Guojun Zhang, Liu Ru
exaly   +6 more sources

NKCC1: A key regulator of glioblastoma progression [PDF]

Molecular Oncology
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with poor prognosis despite multimodal therapy. Chloride cotransporters NKCC1 and KCC2 are key regulators of intracellular chloride levels and thereby determine whether ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
doaj   +3 more sources

Pharmacological tools to target NKCC1 in brain disorders [PDF]

Trends in Pharmacological Sciences, 2021
The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated with several brain disorders. Preclinical/clinical studies have shown that NKCC1 inhibition by the United States FDA-approved diuretic bumetanide is a potential therapeutic strategy in ...
Annalisa Savardi, Marco Borgogno, Marco De Vivo   +2 more
exaly   +4 more sources

CNS pharmacology of NKCC1 inhibitors

Neuropharmacology, 2022
The Na-K-2Cl cotransporter NKCC1 and the neuron-specific K-Cl cotransporter KCC2 are considered attractive CNS drug targets because altered neuronal chloride regulation and consequent effects on GABAergic signaling have been implicated in numerous CNS disorders.
Wolfgang Löscher, Kai Kaila
exaly   +6 more sources

Loss of NKCC1 Activates the NLRP3 Inflammasome in Intestinal EpitheliaSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Potassium and chloride efflux have been reported to regulate nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.
Rainelli B. Koumangoye, Mohammed Z. Ferdaus, Xenia Davis, Julia K. Bohannon, Eric Delpire   +4 more
doaj   +5 more sources

NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data

Cells, 2020
Ionotropic GABA transmission is mediated by anion (mainly Cl−)-permeable GABAA receptors (GABAARs). In immature neurons, GABA exerts depolarizing and sometimes functionally excitatory actions, based on active uptake of Cl− by the Na-K-2Cl cotransporter ...
Mari A Virtanen, Pavel Uvarov, Christian A Hübner   +2 more
exaly   +4 more sources

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin

EBioMedicine, 2017
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. The mechanisms that confer GBM cells their invasive behavior are poorly understood.
Paula Schiapparelli, Hugo Guerrero-Cazares, Roxana Magaña-Maldonado   +2 more
exaly   +3 more sources

Increased NKCC1 expression in refractory human epilepsy

Epilepsy Research, 2007
Cation-chloride co-transporters (CCTs), particularly NKCC1, may be important in epileptogenesis. We have performed a detailed histological examination of NKCC1 in large samples of patients with hippocampal sclerosis (HS) or focal cortical dysplasia (FCD), pathologies both commonly associated with pharmacoresistant epilepsy.
Arjune Sen, Lillian Martinian, Matthew C Walker   +2 more
exaly   +3 more sources

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Bilal MU, Alvi S, Humayune F, Mujtaba H, Ahmad S, Iqbal S, Umer MF.   +6 more
europepmc   +2 more sources

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications. [PDF]

CNS Neurosci Ther
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Han G, Song J, Wan S, Ji X, Zhou D, Meng R.   +5 more
europepmc   +2 more sources