EBioMedicine, 2017 Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. The mechanisms that confer GBM cells their invasive behavior are poorly understood.
Chuan-Hsiang Huang +2 more
exaly +3 more sources
NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data
Cells, 2020 Ionotropic GABA transmission is mediated by anion (mainly Cl−)-permeable GABAA receptors (GABAARs). In immature neurons, GABA exerts depolarizing and sometimes functionally excitatory actions, based on active uptake of Cl− by the Na-K-2Cl cotransporter ...
Pavel Uvarov +2 more
exaly +3 more sources
Propofol-Facilitated Recovery Sleep Modulates Cognitive Function via Slow Oscillation-Spindle Coupling After Acute Sleep Deprivation in Rats. [PDF]
CNS Neurosci TherThis study examined how propofol‐supported recovery sleep shapes cognitive and sleep‐EEG outcomes after 48‐h SD. Rats received Barnes maze, 2‐h and 24‐h NOR testing, cortical EEG/EMG recording, and NKCC1/KCC2 expression analysis. Propofol increased slow‐oscillation density and restored precise SO–spindle alignment, accompanied by a shift in NKCC1/KCC2 ...
Yang C, Liu H, Wang X, Zhang L, Wang H.
europepmc +2 more sources
Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors [PDF]
Frontiers in ChemistryIntroductionThe Na–K–2Cl cotransporter isoform 1 (NKCC1) regulates cell volume and ionic distribution, thereby also controlling the efficacy of neuronal GABAergic inhibition. enhanced activity of the NKCC1 chloride importer and high Cl.
Gerald Coste +5 more
doaj +2 more sources
NKCC1: A key regulator of glioblastoma progression [PDF]
Molecular OncologyGlioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with poor prognosis despite multimodal therapy. Chloride cotransporters NKCC1 and KCC2 are key regulators of intracellular chloride levels and thereby determine whether ...
Anja Thomsen +5 more
doaj +2 more sources
Renin-Angiotensin Signaling and Vascular Function: Insights into Health and Disease. [PDF]
Acta Physiol (Oxf)ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Bertoldi G, Sonkusare SK.
europepmc +2 more sources
Loss of NKCC1 Activates the NLRP3 Inflammasome in Intestinal EpitheliaSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Potassium and chloride efflux have been reported to regulate nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.
Rainelli B. Koumangoye +4 more
doaj +2 more sources
Neonatal seizures and GABAergic drugs: Scylla and Charybdis? [PDF]
Epilepsia OpenAbstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Thompson KW +2 more
europepmc +2 more sources
Rethinking GABAergic therapy in neonatal seizures: Beyond Scylla and Charybdis. [PDF]
Epilepsia OpenEpilepsia Open, EarlyView.
Falsaperla R, Sortino V, Ramantani G.
europepmc +2 more sources
Olfactory ensheathing cell transplantation targets macrophage extracellular traps and NKCC1 to alleviate pain after spinal cord injury [PDF]
Molecular PainSpinal cord injury (SCI) triggers neuropathic pain through inflammatory secondary injury. Olfactory ensheathing cells (OECs) hold therapeutic promise, but their pain-relieving mechanisms are unclear.
Honghui Lei +4 more
doaj +2 more sources