Results 11 to 20 of about 7,960 (193)

The apical NKCC1 cotransporter debate

The FASEB Journal, 2012
Choroid plexus epithelial cells (CPECs) secrete cerebrospinal fluid (CSF) and regulate its electrolyte composition. CPECs express Na + /K + ATPase and Na + ‐K + ‐2Cl
Crum, Jeannine Marie, Alvarez, Francisco J., Alvarez-Leefmans, Francisco J.   +2 more
core   +5 more sources

Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke [PDF]

Journal of Neuroinflammation, 2022
Background The mechanisms underlying dysfunction of choroid plexus (ChP) blood–cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood.
Jun Wang, Ruijia Liu, Md Nabiul Hasan, Sydney Fischer, Yang Chen, Matt Como, Victoria M. Fiesler, Mohammad Iqbal H. Bhuiyan, Shuying Dong, Eric Li, Kristopher T. Kahle, Jinwei Zhang, Xianming Deng, Arohan R. Subramanya, Gulnaz Begum, Yan Yin, Dandan Sun   +16 more
doaj   +9 more sources

Intestinal ion transport in NKCC1-deficient mice [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000
The Na+-K+-2Cl−cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl−entry pathway. With targeted mutagenesis, mice deficient in the NKCC1 protein were generated. The basal short-circuit current did not differ between normal and NKCC1 −/− jejuna.
B R, Grubb, E, Lee, A J, Pace, B H, Koller, R C, Boucher   +4 more
core   +4 more sources

Alterations in airway ion transport in NKCC1-deficient mice [PDF]

American Journal of Physiology-Cell Physiology, 2001
Airways of Na+-K+-2Cl−(NKCC1)-deficient mice (−/−) were studied in Ussing chambers to determine the role of the basolateral NKCC1 in transepithelial anion secretion. The basal short-circuit current ( I sc) of tracheae and bronchi from adult mice did not differ between NKCC1−/− and normal mice, whereas NKCC1−/− tracheae from neonatal mice exhibited a ...
B R, Grubb, A J, Pace, E, Lee, B H, Koller, R C, Boucher   +4 more
core   +4 more sources

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function [PDF]

Frontiers in Neurology, 2020
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu, Ru Liu, Ru Liu, Ru Liu, Junling Wang, Junling Wang, Junling Wang, Junling Wang, Shuli Liang, Guojun Zhang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +13 more
doaj   +3 more sources

Ion Transporter NKCC1, Modulator of Neurogenesis in Murine Olfactory Neurons [PDF]

Journal of Biological Chemistry, 2015
Olfaction is one of the most crucial senses for vertebrates regarding foraging and social behavior. Therefore, it is of particular interest to investigate the sense of smell, its function on a molecular level, the signaling proteins involved in the process and the mechanism of required ion transport.
Haering, C., Kanageswaran, N., Bouvain, P., Scholz, P., Altmüller, J., Becker, C., Gisselmann, G., Wäring-Bischof, J., Hatt, H.   +8 more
openaire   +4 more sources

NKCC1-deficiency results in abnormal proliferation of neural progenitor cells of the lateral ganglionic eminence

Frontiers in Cellular Neuroscience, 2016
The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter NKCC1 is important for regulating cell volume and the proliferation of different cell types in vitro.
Ana Cathia Magalhães, Claudio Rivera, Claudio Rivera, Claudio Rivera   +3 more
doaj   +2 more sources

Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain [PDF]

Acta Neuropathologica Communications
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in infants and toddlers, with limited treatment options and persistent neurological sequelae.
Alexandra Hochstetler, Ya’el Courtney, Peace Oloko, Benjamin Baskin, Andrew Ding-Su, Tawny Stinson, Elyssa Alber, David Y. Chung, Declan McGuone, Robin Haynes, Maria K. Lehtinen, Beth Costine-Bartell   +11 more
doaj   +2 more sources

Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia

Molecular Pain, 2007
Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando, Entrena Jose M, Price Theodore J, Pitcher Mark H   +3 more
doaj   +4 more sources

Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses

Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses, 2023
doctoral 医学系研究科 A pathological excitatory action of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) has been observed in epilepsy. Blocking the Cl⁻ importer NKCCl with bumetanide is expected to reduce the neuronal intracellular Cl⁻ concentration ([Cl⁻]i) and thereby attenuate the excitatory GABA response.
Trong Dao Nguyen, Masaru Ishibashi, Adya Saran Sinha, Miho Watanabe, Daisuke Kato, Hiroshi Horiuchi, Hiroaki Wake, Atsuo Fukuda   +7 more
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