Results 11 to 20 of about 8,301 (197)

Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1

Fluids and Barriers of the CNS, 2023
Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles in regulating CSF volume by co-transporting ...
Ryann M. Fame, Huixin Xu, Aja Pragana, Maria Lehtinen   +3 more
doaj   +2 more sources

Astrocytic NKCC1 inhibits seizures by buffering Cl⁻ and antagonizing neuronal NKCC1 at GABAergic synapses

Epilepsia, 2023
AbstractObjectiveA pathological excitatory action of the major inhibitory neurotransmitter γ‐aminobutyric acid (GABA) has been observed in epilepsy. Blocking the Cl− importer NKCC1 with bumetanide is expected to reduce the neuronal intracellular Cl− concentration ([Cl−]i) and thereby attenuate the excitatory GABA response. Accordingly, several clinical
Trong Dao Nguyen, Masaru Ishibashi, Adya Saran Sinha, Miho Watanabe, Daisuke Kato, Hiroshi Horiuchi, Hiroaki Wake, Atsuo Fukuda   +7 more
openaire   +3 more sources

Seizures regulate the cation-Cl− cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission

Frontiers in Neurology, 2023
BackgroundThe balance between the activity of the Na+/K+/Cl− cotransporter (NKCC1) that introduces Cl− into the cell and the K+/Cl− cotransporter (KCC2) that transports Cl− outside the cell is critical in determining the inhibitory or excitatory outcome ...
Juan-Manuel Bonet-Fernández, Juan-Manuel Bonet-Fernández, Pedro Tranque, Pedro Tranque, Jose Daniel Aroca-Aguilar, Luis J. Muñoz, Dolores E. López, Julio Escribano, Carlos de Cabo   +8 more
doaj   +2 more sources

Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway

Cells, 2023
An upregulation of the Na+-K+-2Cl− cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABAARs) and, thus, to hyperactivity.
Etienne Côme, Simon Blachier, Juliette Gouhier, Marion Russeau, Sabine Lévi   +4 more
doaj   +2 more sources

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.

PLoS Biology, 2022
The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in
Krisztina Tóth, Nikolett Lénárt, Péter Berki, Rebeka Fekete, Eszter Szabadits, Balázs Pósfai, Csaba Cserép, Ahmad Alatshan, Szilvia Benkő, Dániel Kiss, Christian A Hübner, Attila Gulyás, Kai Kaila, Zsuzsanna Környei, Ádám Dénes   +14 more
doaj   +2 more sources

Structure and mechanism of the cation–chloride cotransporter NKCC1 [PDF]

Nature, 2019
Cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume, controlling ion absorption and secretion across epithelia, and maintaining intracellular chloride homeostasis.
Wang, Amy, Liao, Maofu, Liang, Feng, Chew, Thomas, Orlando, Benjamin, Latorraca, Naomi, Zhang, Jinru, Hollingsworth, Scott, Chen, Dong-Hua, Dror, Ron   +9 more
openaire   +5 more sources

NKCC1 and KCC2: Structural insights into phospho-regulation

Frontiers in Molecular Neuroscience, 2022
Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl– concentration in neurons.
Anna-Maria Hartmann, Anna-Maria Hartmann, Hans Gerd Nothwang, Hans Gerd Nothwang, Hans Gerd Nothwang   +4 more
openaire   +5 more sources

Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke

Journal of Neuroinflammation, 2022
Background The mechanisms underlying dysfunction of choroid plexus (ChP) blood–cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood.
Jun Wang, Ruijia Liu, Md Nabiul Hasan, Sydney Fischer, Yang Chen, Matt Como, Victoria M. Fiesler, Mohammad Iqbal H. Bhuiyan, Shuying Dong, Eric Li, Kristopher T. Kahle, Jinwei Zhang, Xianming Deng, Arohan R. Subramanya, Gulnaz Begum, Yan Yin, Dandan Sun   +16 more
doaj   +2 more sources

Inhibition of NKCC1 in spinal dorsal horn and dorsal root ganglion results in alleviation of neuropathic pain in rats with spinal cord contusion

Molecular Pain, 2023
Previous studies have confirmed the relationship between chloride homeostasis and pain. However, the role of sodium potassium chloride co-transporter isoform 1 (NKCC1) in dorsal horn and dorsal root ganglion neurons (DRGs) in spinal cord injury (SCI ...
Yao Wu, Fangyong Wang
doaj   +2 more sources

NKCC1 Deficiency in Forming Hippocampal Circuits Triggers Neurodevelopmental Disorder: Role of BDNF-TrkB Signalling

Brain Sciences, 2022
The time-sensitive GABA shift from excitatory to inhibitory is critical in early neural circuits development and depends upon developmentally regulated expression of cation-chloride cotransporters NKCC1 and KCC2.
Jacek Szymanski, Liliana Minichiello
doaj   +2 more sources