Results 11 to 20 of about 10,422 (209)

Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia

Molecular Pain, 2007
Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando, Entrena Jose M, Price Theodore J, Pitcher Mark H   +3 more
doaj   +4 more sources

Improving NKCC1 Function Increases the Excitability of DRG Neurons Exacerbating Pain Induced After TRPV1 Activation of Primary Sensory Neurons

Frontiers in Cellular Neuroscience, 2021
Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor
Shi-Yu Deng, Shi-Yu Deng, Shi-Yu Deng, Xue-Chun Tang, Xue-Chun Tang, Xue-Chun Tang, Yue-Chen Chang, Yue-Chen Chang, Yue-Chen Chang, Zhen-Zhen Xu, Zhen-Zhen Xu, Zhen-Zhen Xu, Qin-Yi Chen, Qin-Yi Chen, Nan Cao, Nan Cao, Liang-Jing-Yuan Kong, Liang-Jing-Yuan Kong, Yang Wang, Yang Wang, Ke-Tao Ma, Ke-Tao Ma, Li Li, Li Li, Li Li, Jun-Qiang Si, Jun-Qiang Si   +26 more
doaj   +1 more source

The roles of sodium-potassium-chloride cotransporter isoform-1 in acute lung injury

Tzu Chi Medical Journal, 2022
Acute lung injury (ALI) is often characterized by severe lung inflammation and pulmonary edema with poor gas exchange and hypoxemia. Alveolar inflammation and water flooding are, in fact, notable features of ALI pathogenesis.
Po-Chun Hsieh, Yao-Kuang Wu, Chan-Yen Kuo, Yen-Hsien Lee, Mei-Chen Yang, Chou-Chin Lan   +5 more
doaj   +1 more source

Mice lacking NKCC1 have normal olfactory sensitivity [PDF]

Physiology & Behavior, 2008
When olfactory receptor neurons respond to odors, a depolarizing Cl(-) efflux is a substantial part of the response. This requires that the resting neuron accumulate Cl(-) against an electrochemical gradient. In isolated olfactory receptor neurons, the Na(+)+K(+)+2Cl(-) cotransporter NKCC1 is essential for Cl(-) accumulation.
Department of Psychology, University of Florida, Gainesville, FL 32611, United States ( host institution ), Smith, David W. ( author ), Thach, Sokunthirith ( author ), Marshall, Erika L. ( author ), Mendoza, Mary-Grace ( author ), Kleene, Steven J. ( author )   +5 more
openaire   +3 more sources

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications. [PDF]

CNS Neurosci Ther
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Han G, Song J, Wan S, Ji X, Zhou D, Meng R.   +5 more
europepmc   +2 more sources

Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1

Fluids and Barriers of the CNS, 2023
Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles in regulating CSF volume by co-transporting ...
Ryann M. Fame, Huixin Xu, Aja Pragana, Maria Lehtinen   +3 more
doaj   +1 more source

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. [PDF]

, 2020
Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Brohawn, Stephen Graf, Kern, David M, Reid, Michelle S   +2 more
core   +2 more sources

Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke

Journal of Neuroinflammation, 2022
Background The mechanisms underlying dysfunction of choroid plexus (ChP) blood–cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood.
Jun Wang, Ruijia Liu, Md Nabiul Hasan, Sydney Fischer, Yang Chen, Matt Como, Victoria M. Fiesler, Mohammad Iqbal H. Bhuiyan, Shuying Dong, Eric Li, Kristopher T. Kahle, Jinwei Zhang, Xianming Deng, Arohan R. Subramanya, Gulnaz Begum, Yan Yin, Dandan Sun   +16 more
doaj   +1 more source

NKCC1 cotransporters: keeping an ‘ion’ them

The Journal of Physiology, 2011
The sodium–potassium–chloride cotransporter NKCC1 has a track record of bringing the ions it is named after into the cell. But recently, scientists discovered that the cotransporter brings a substantial amount of water into the cell as well. In a recent issue of The Journal of Physiology, Hamann et al. (2010) analysed cell volumes of human pigmented
George, Perez-Trevino, Sébastien, Vidal
openaire   +5 more sources

Astrocytic NKCC1 inhibits seizures by buffering Cl⁻ and antagonizing neuronal NKCC1 at GABAergic synapses

Epilepsia, 2023
AbstractObjectiveA pathological excitatory action of the major inhibitory neurotransmitter γ‐aminobutyric acid (GABA) has been observed in epilepsy. Blocking the Cl− importer NKCC1 with bumetanide is expected to reduce the neuronal intracellular Cl− concentration ([Cl−]i) and thereby attenuate the excitatory GABA response. Accordingly, several clinical
Trong Dao Nguyen, Masaru Ishibashi, Adya Saran Sinha, Miho Watanabe, Daisuke Kato, Hiroshi Horiuchi, Hiroaki Wake, Atsuo Fukuda   +7 more
openaire   +2 more sources