Results 31 to 40 of about 8,301 (197)

Improving NKCC1 Function Increases the Excitability of DRG Neurons Exacerbating Pain Induced After TRPV1 Activation of Primary Sensory Neurons

Frontiers in Cellular Neuroscience, 2021
Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor
Shi-Yu Deng, Shi-Yu Deng, Shi-Yu Deng, Xue-Chun Tang, Xue-Chun Tang, Xue-Chun Tang, Yue-Chen Chang, Yue-Chen Chang, Yue-Chen Chang, Zhen-Zhen Xu, Zhen-Zhen Xu, Zhen-Zhen Xu, Qin-Yi Chen, Qin-Yi Chen, Nan Cao, Nan Cao, Liang-Jing-Yuan Kong, Liang-Jing-Yuan Kong, Yang Wang, Yang Wang, Ke-Tao Ma, Ke-Tao Ma, Li Li, Li Li, Li Li, Jun-Qiang Si, Jun-Qiang Si   +26 more
doaj   +1 more source

Choroid plexus targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus

Neuron, 2023
SUMMARY Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH).
C. Sadegh, Huixin Xu, J. Sutin, B. Fatou, Suhasini Gupta, Aja Pragana, Milo Taylor, P. N. Kalugin, Miriam E. Zawadzki, Osama Alturkistani, Frederick B. Shipley, Neil Dani, Ryann M. Fame, Zainab Wurie, Pratik Talati, Riana L. Schleicher, Eric M. Klein, Yong Zhang, M. Holtzman, C. Moore, Pei-Yi Lin, Aman B. Patel, B. Warf, W. T. Kimberly, H. Steen, M. Andermann, Maria K. Lehtinen   +26 more
semanticscholar   +1 more source

The roles of sodium-potassium-chloride cotransporter isoform-1 in acute lung injury

Tzu Chi Medical Journal, 2022
Acute lung injury (ALI) is often characterized by severe lung inflammation and pulmonary edema with poor gas exchange and hypoxemia. Alveolar inflammation and water flooding are, in fact, notable features of ALI pathogenesis.
Po-Chun Hsieh, Yao-Kuang Wu, Chan-Yen Kuo, Yen-Hsien Lee, Mei-Chen Yang, Chou-Chin Lan   +5 more
doaj   +1 more source

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders

Molecules, 2023
Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale ...
P. Lam, Julia Newland, Richard L. M. Faull, A. Kwakowsky   +3 more
semanticscholar   +1 more source

In vitro investigation of the effect of proinflammatory cytokines on mouse choroid plexus membrane transporters Ncbe and NKCC1

Fluids and Barriers of the CNS, 2023
Intraventricular hemorrhage is a potentially life-threatening condition. Approximately 20% of patients develop posthemorrhagic hydrocephalus with increased ventricular volume and intracranial pressure.
Laura Øllegaard Johnsen, K. Friis, H. Damkier   +2 more
semanticscholar   +1 more source

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

Communications Biology, 2021
NKCC and KCC transporters mediate coupled transport of Na + +K + +Cl − and K + +Cl − across the plasma membrane, thus regulating cell Cl − concentration and cell volume and playing critical roles in transepithelial salt and water transport and in ...
Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel, W. Zhuo, Suma Somasekharan, Kasturi Roy, Laixing Zhang, Yang Liu, Xianbin Meng, Haiteng Deng, Wenwen Zeng, Guohui Li, B. Forbush, Maojun Yang   +15 more
semanticscholar   +1 more source

Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Nature Communications, 2021
Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neurodevelopment.
Huixin Xu, Ryann M. Fame, C. Sadegh, J. Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda N Vernon, Fan Gao, Yong Zhang, M. Holtzman, M. Heiman, B. Warf, Pei-Yi Lin, Maria K. Lehtinen   +15 more
semanticscholar   +1 more source

Cation Chloride Cotransporter NKCC1 Operates through a Rocking-Bundle Mechanism

Journal of the American Chemical Society, 2023
The sodium, potassium, and chloride cotransporter 1 (NKCC1) plays a key role in tightly regulating ion shuttling across cell membranes. Lately, its aberrant expression and function have been linked to numerous neurological disorders and cancers, making ...
Manuel Jose Ruiz Munevar, Valerio Rizzi, Corinne Portioli, Pietro Vidossich, Erhu Cao, Michele Parrinello, L. Cancedda, Marco De Vivo   +7 more
semanticscholar   +1 more source

Preclinical Development of the Na-K-2Cl Co-transporter-1 (NKCC1) Inhibitor ARN23746 for the Treatment of Neurodevelopmental Disorders.

ACS Pharmacology & Translational Science, 2023
Alterations in the expression of the Cl- importer Na-K-2Cl co-transporter-1 (NKCC1) and the exporter K-Cl co-transporter 2 (KCC2) lead to impaired intracellular chloride concentration in neurons and imbalanced excitation/inhibition in the brain.
Annalisa Savardi, A. Patricelli Malizia, Marco De Vivo, L. Cancedda, Marco Borgogno   +4 more
semanticscholar   +1 more source

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Nature Communications, 2022
Cation-chloride cotransporters (CCCs) NKCC1 and NKCC2 catalyze electroneutral symport of 1 Na+, 1 K+, and 2 Cl− across cell membranes. NKCC1 mediates trans-epithelial Cl− secretion and regulates excitability of some neurons and NKCC2 is critical to renal
Yongxiang Zhao, Kasturi Roy, Pietro Vidossich, L. Cancedda, Marco De Vivo, B. Forbush, E. Cao   +6 more
semanticscholar   +1 more source