Results 31 to 40 of about 7,960 (193)

Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats

Frontiers in Molecular Neuroscience, 2021
Aims: To determine whether acid-sensing ion channel 1 (ASIC1)–sodium-potassium-chloride cotransporter 1 (NKCC1) signaling pathway participates in chronic visceral pain of adult rats with neonatal maternal deprivation (NMD).Methods: Chronic visceral pain ...
Yong-Chang Li, Yuan-Qing Tian, Yan-Yan Wu, Yu-Cheng Xu, Ping-An Zhang, Jie Sha, Guang-Yin Xu   +6 more
doaj   +1 more source

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]

Epilepsy Research, 2008
During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu, Nathan, Polley, Gregory C, Mathews, Eric, Delpire   +3 more
openaire   +2 more sources

NKCC1 and KCC2: Structural insights into phospho-regulation

Frontiers in Molecular Neuroscience, 2022
Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl– concentration in neurons.
Anna-Maria Hartmann, Anna-Maria Hartmann, Hans Gerd Nothwang, Hans Gerd Nothwang, Hans Gerd Nothwang   +4 more
openaire   +4 more sources

NKCC1 Deficiency in Forming Hippocampal Circuits Triggers Neurodevelopmental Disorder: Role of BDNF-TrkB Signalling

Brain Sciences, 2022
The time-sensitive GABA shift from excitatory to inhibitory is critical in early neural circuits development and depends upon developmentally regulated expression of cation-chloride cotransporters NKCC1 and KCC2.
Jacek Szymanski, Liliana Minichiello
doaj   +1 more source

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

Frontiers in Cell and Developmental Biology, 2019
Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na+-K+-2Cl– cotransporters 1 (NKCC1) is dramatically upregulated after hypoxia-ischemia (HI),
Xing-Liang Yang, Meng-Liu Zeng, Lin Shao, Guang-Tong Jiang, Jing-Jing Cheng, Tao-Xiang Chen, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He, Bi-Wen Peng   +10 more
doaj   +1 more source

Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Frontiers in Physiology, 2020
Introduction: Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) is important in regulating intracellular K+ and Cl− homeostasis and cell volume. In this study, we investigated a role of NKCC1 in regulating glioma K+ influx and proliferation in response to ...
Lanxin Luo, Lanxin Luo, Jun Wang, Jun Wang, Dawei Ding, Dawei Ding, Md Nabiul Hasan, Sung-Sen Yang, Shih-Hua Lin, Philipp Schreppel, Baoshan Sun, Yan Yin, Thomas Erker, Dandan Sun, Dandan Sun   +14 more
doaj   +1 more source

Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy

Neurobiology of Disease, 2021
Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-specific inhibitor, bumetanide, are equivocal, which is a consequence of the ...
Philip Hampel, Marie Johne, Björn Gailus, Alexandra Vogel, Alina Schidlitzki, Birthe Gericke, Kathrin Töllner, Wiebke Theilmann, Christopher Käufer, Kerstin Römermann, Kai Kaila, Wolfgang Löscher   +11 more
doaj   +1 more source

Impact of Hybrid and Complex N-Glycans on Cell Surface Targeting of the Endogenous Chloride Cotransporter Slc12a2

International Journal of Cell Biology, 2015
The Na+K+2Cl− cotransporter-1 (Slc12a2, NKCC1) is widely distributed and involved in cell volume/ion regulation. Functional NKCC1 locates in the plasma membrane of all cells studied, particularly in the basolateral membrane of most polarized cells ...
Richa Singh, Mohammed Mashari Almutairi, Romario Pacheco-Andrade, Mohamed Y. Mahmoud Almiahuob, Mauricio Di Fulvio   +4 more
doaj   +1 more source

Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway

Cells, 2023
An upregulation of the Na+-K+-2Cl− cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABAARs) and, thus, to hyperactivity.
Etienne Côme, Simon Blachier, Juliette Gouhier, Marion Russeau, Sabine Lévi   +4 more
doaj   +1 more source

COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination

American Journal of Physiology-Cell Physiology, 2013
Mice deficient in Na-K-2Cl cotransporter (NKCC1) have been generated by targeted disruption of the gene encoding NKCC1 involving the carboxy terminus (CT-NKCC1) but not the amino terminus. We hypothesize that the resulting physiological defects are due to loss of proteins interacting with CT-NKCC1.
Laura, Smith, Paul, Litman, Carole M, Liedtke   +2 more
openaire   +3 more sources