Results 1 to 10 of about 4,352 (128)

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex. [PDF]

Epilepsia
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Guo D, Han L, Rensing NR, Jansen LA, Wong M.   +4 more
europepmc   +2 more sources

Propofol-Facilitated Recovery Sleep Modulates Cognitive Function via Slow Oscillation-Spindle Coupling After Acute Sleep Deprivation in Rats. [PDF]

CNS Neurosci Ther
This study examined how propofol‐supported recovery sleep shapes cognitive and sleep‐EEG outcomes after 48‐h SD. Rats received Barnes maze, 2‐h and 24‐h NOR testing, cortical EEG/EMG recording, and NKCC1/KCC2 expression analysis. Propofol increased slow‐oscillation density and restored precise SO–spindle alignment, accompanied by a shift in NKCC1/KCC2 ...
Yang C, Liu H, Wang X, Zhang L, Wang H.
europepmc   +2 more sources

Learning Dynamics in Biophysical Spiking Network Models Are Shaped by KCC2/NKCC1 Cotransporter Stoichiometry. [PDF]

Eur J Neurosci
Neuronal chloride homeostasis, governed by KCC2 and NKCC1 cotransporters, constrains convergence to learning in biophysical spiking neural networks. Systematic exploration of transporter activity shows that successful learning emerges only within a restricted parameter regime, whose boundaries and convergence properties critically depend on NKCC1 ...
Ahmed M, Guimarães de Almeida AC, Rodrigues AM, Depannemaecker D.   +3 more
europepmc   +2 more sources

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2-developmental and epileptic encephalopathy. [PDF]

Epilepsia
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Hamze M, Whitney R, Ville D, Villeneuve N, Hartmann AM, Becker L, Hausmann J, Zhang J, Brier C, Pisella LI, Friedel P, Labalme A, Alix E, Chatron N, Sanlaville D, Gory-Fauré S, Denarier E, Porcher C, Lesca G, Medina I.   +19 more
europepmc   +2 more sources

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment. [PDF]

Channels (Austin)
Neuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter.
Kok M, Aizenman E, Guerriero CJ, Brodsky JL.   +3 more
europepmc   +2 more sources

NKCC1: A key regulator of glioblastoma progression. [PDF]

Mol Oncol
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Thomsen A, Freitag D, Haase M, Senft C, Schwarz F, Keiner S.   +5 more
europepmc   +2 more sources

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

EBioMedicine, 2018
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic ...
Ross A Cardarelli, Nicholas J Brandon, Joshua Smalley   +2 more
exaly   +3 more sources

Neonatal seizures and GABAergic drugs: Scylla and Charybdis? [PDF]

Epilepsia Open
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Thompson KW, Suchomelova L, Wasterlain CG.   +2 more
europepmc   +2 more sources

KCC2 activation during postnatal development alleviates long-term deficits in CDKL5-deficient mice. [PDF]

Exp Mol Med
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe developmental and epileptic encephalopathy characterized by early onset drug-resistant seizures and later cognitive and social impairments.
Arshad MN, Bope C, Cho N, Dengler JS, Ng SFJ, Smalley JL, Nishi T, Zhong Z, Moss SJ, Davies PA.   +9 more
europepmc   +2 more sources

Development of KCC2 therapeutics to treat neurological disorders

Frontiers in Molecular Neuroscience
KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS.
Shilpa D. Kadam
exaly   +3 more sources