Results 1 to 10 of about 8,156 (210)

KCC2 function modulates in vitro ictogenesis [PDF]

Neurobiology of Disease, 2015
GABAA receptor-mediated inhibition is active and may contribute to epileptiform synchronization. The efficacy of inhibition relies on low levels of intracellular Cl−, which are controlled by KCC2 activity.
Shabnam Hamidi, Massimo Avoli
exaly   +5 more sources

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment [PDF]

Channels
Neuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter.
Morgan Kok, Elias Aizenman, Christopher J. Guerriero, Jeffrey L. Brodsky   +3 more
doaj   +2 more sources

Orexin-A Inhibits Lipopolysaccharide-Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling. [PDF]

J Cell Biochem
ABSTRACT It has been suggested that orexin‐A (OXA) exerts neuroprotective and anti‐inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed to investigate whether OXA could inhibit astrocyte migration induced by lipopolysaccharide (LPS ...
Shin H, Choi SR, Kang DW, Lee H, Park J, Lee M, Bae M, Ryu Y, Kang SY, Chae CW, Kim HW.   +10 more
europepmc   +2 more sources

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post-Stroke Seizure Susceptibility. [PDF]

CNS Neurosci Ther
Ischemic stroke induces microglial activation and BDNF–TrkB signaling, leading to KCC2 downregulation and seizure susceptibility. Pharmacological inhibition of microglia or TrkB and restoration of KCC2 function with the chloride extrusion enhancer CLP290 attenuate post‐ischemic seizures.
Zhou J, Wang BH, Yu J, Wang G, Cai J, Yu M, Chen K, Wan L, Liu X, Yang Z, Wang Y, Wang Y.   +11 more
europepmc   +2 more sources

KCC2 activation during postnatal development alleviates long-term deficits in CDKL5-deficient mice [PDF]

Experimental and Molecular Medicine
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe developmental and epileptic encephalopathy characterized by early onset drug-resistant seizures and later cognitive and social impairments.
Muhammad Nauman Arshad, Christopher Bope, Noell Cho, Jacob S. Dengler, Shu Fun Josephine Ng, Joshua L. Smalley, Toshiya Nishi, Zhong Zhong, Stephen J. Moss, Paul A. Davies   +9 more
doaj   +2 more sources

Potassium-chloride cotransporter 2 activity dampens induced ictal-like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients. [PDF]

Epilepsia
The K⁺/Cl− cotransporter (KCC2) limits induced ictal‐like events and their spread in the supragranular layer of human neocortical slices from the seizure‐propagation zone of temporal lobe epilepsy patients. Cl⁻ extrusion is present in supragranular pyramidal neurons but limited under high somatic Cl⁻ load.
Falck A, Lehnhoff J, Behbood M, Byvaltcev E, Aigner A, Radbruch H, Fidzinski P, Schleimer JH, Janach GMS, Döhne N, Onken J, Kalbhenn T, Sauvigny T, Deisz RA, Schreiber S, Holtkamp M, Strauss U.   +16 more
europepmc   +2 more sources

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

EBioMedicine, 2018
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic ...
Matthew R Kelley, Ross A Cardarelli, Joshua L Smalley   +2 more
exaly   +3 more sources

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

Cell Reports, 2019
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Liset Menendez de la Prida, Jean Christophe Poncer   +1 more
exaly   +3 more sources

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library [PDF]

Frontiers in Molecular Neuroscience
IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Claudio Rivera, Anastasia Ludwig   +12 more
doaj   +2 more sources

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q [PDF]

Frontiers in Molecular Neuroscience
IntroductionThe potassium chloride co-transporter 2 (KCC2) is the principal Cl− extrusion mechanism employed by mature neurons in the central nervous system (CNS) and plays a critical role in determining the efficacy of fast synaptic inhibition mediated ...
Jinglin Ji, Catherine Choi, Christopher E. Bope, Jacob S. Dengler, Stephen J. Moss, Joshua L. Smalley   +5 more
doaj   +2 more sources