Results 1 to 10 of about 5,407 (200)

Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus

Frontiers in Cellular Neuroscience, 2011
The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus.
Ilgam Khalilov, Genevieve Chazal, Ilona Chudotvorova   +2 more
exaly   +4 more sources

KCC2 function modulates in vitro ictogenesis [PDF]

Neurobiology of Disease, 2015
GABAA receptor-mediated inhibition is active and may contribute to epileptiform synchronization. The efficacy of inhibition relies on low levels of intracellular Cl−, which are controlled by KCC2 activity.
Shabnam Hamidi, Massimo Avoli
exaly   +5 more sources

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

EBioMedicine, 2018
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic ...
Matt R Kelley, Ross A Cardarelli, Joshua L Smalley   +2 more
exaly   +4 more sources

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment [PDF]

Channels
Neuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter.
Morgan Kok, Elias Aizenman, Christopher J. Guerriero, Jeffrey L. Brodsky   +3 more
doaj   +2 more sources

Orexin-A Inhibits Lipopolysaccharide-Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling. [PDF]

J Cell Biochem
ABSTRACT It has been suggested that orexin‐A (OXA) exerts neuroprotective and anti‐inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed to investigate whether OXA could inhibit astrocyte migration induced by lipopolysaccharide (LPS ...
Shin H, Choi SR, Kang DW, Lee H, Park J, Lee M, Bae M, Ryu Y, Kang SY, Chae CW, Kim HW.   +10 more
europepmc   +2 more sources

NKCC1: A key regulator of glioblastoma progression. [PDF]

Mol Oncol
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Thomsen A, Freitag D, Haase M, Senft C, Schwarz F, Keiner S.   +5 more
europepmc   +2 more sources

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post-Stroke Seizure Susceptibility. [PDF]

CNS Neurosci Ther
Ischemic stroke induces microglial activation and BDNF–TrkB signaling, leading to KCC2 downregulation and seizure susceptibility. Pharmacological inhibition of microglia or TrkB and restoration of KCC2 function with the chloride extrusion enhancer CLP290 attenuate post‐ischemic seizures.
Zhou J, Wang BH, Yu J, Wang G, Cai J, Yu M, Chen K, Wan L, Liu X, Yang Z, Wang Y, Wang Y.   +11 more
europepmc   +2 more sources

KCC2 activation during postnatal development alleviates long-term deficits in CDKL5-deficient mice [PDF]

Experimental and Molecular Medicine
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe developmental and epileptic encephalopathy characterized by early onset drug-resistant seizures and later cognitive and social impairments.
Muhammad Nauman Arshad, Christopher Bope, Noell Cho, Jacob S. Dengler, Shu Fun Josephine Ng, Joshua L. Smalley, Toshiya Nishi, Zhong Zhong, Stephen J. Moss, Paul A. Davies   +9 more
doaj   +2 more sources

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q [PDF]

Frontiers in Molecular Neuroscience
IntroductionThe potassium chloride co-transporter 2 (KCC2) is the principal Cl− extrusion mechanism employed by mature neurons in the central nervous system (CNS) and plays a critical role in determining the efficacy of fast synaptic inhibition mediated ...
Jinglin Ji, Catherine Choi, Christopher E. Bope, Jacob S. Dengler, Stephen J. Moss, Joshua L. Smalley   +5 more
doaj   +2 more sources

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures [PDF]

Frontiers in Neuroscience
IntroductionKetogenic diet (KD), a high-fat, low-carbohydrate, and adequate protein diet, is a non-pharmacological treatment for refractory epilepsy. However, their mechanism of action is not fully understood.
Leticia Granados-Rojas, Leonardo Hernández-López, Emmanuel Leonardo Bahena-Alvarez, Tarsila Elizabeth Juárez-Zepeda, Verónica Custodio, Joyce Graciela Martínez-Galindo, Karina Jerónimo-Cruz, Miguel Tapia-Rodríguez, America Vanoye-Carlo, Pilar Duran, Carmen Rubio   +10 more
doaj   +2 more sources