Results 11 to 20 of about 8,156 (210)
Frontiers in Cellular Neuroscience, 2023 K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Abhishek Pethe +7 more
doaj +5 more sources
KCC2 downregulation facilitates epileptic seizures [PDF]
Scientific Reports, 2017 GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl− cotransporter-2 (KCC2).
Lulan Chen +6 more
doaj +3 more sources
Therapeutic potential for KCC2-targeted neurological diseases
Japanese Dental Science Review, 2023 Patients with neurological diseases, such as schizophrenia, tend to show low K+-Cl- co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation.
Kazuo Tomita +11 more
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The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice [PDF]
Data in Brief, 2016 K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative diseases.
Takao Tsukahara +4 more
doaj +3 more sources
Development of KCC2 therapeutics to treat neurological disorders
Frontiers in Molecular NeuroscienceKCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS.
Shilpa D. Kadam, Shane V. Hegarty
doaj +3 more sources
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation [PDF]
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
doaj +3 more sources
Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures [PDF]
Frontiers in NeuroscienceIntroductionKetogenic diet (KD), a high-fat, low-carbohydrate, and adequate protein diet, is a non-pharmacological treatment for refractory epilepsy. However, their mechanism of action is not fully understood.
Leticia Granados-Rojas +10 more
doaj +2 more sources
Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett Syndrome [PDF]
, 2013 Objective: Rett Syndrome is a progressive neurodevelopmental disorder caused mainly by mutations in the gene encoding methyl-CpG-binding protein 2. The relevance of MeCP2 for GABAergic function was previously documented in animal models. In these models,
Armstrong, Judith +11 more
core +17 more sources
Frontiers in Cell and Developmental Biology, 2022 KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and ...
Francis J. Prael III +12 more
doaj +1 more source
Cells, 2022 KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated.
Anastasia Rigkou +3 more
doaj +1 more source