Results 11 to 20 of about 5,952 (193)

KCC2 downregulation facilitates epileptic seizures [PDF]

Scientific Reports, 2017
GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl− cotransporter-2 (KCC2).
Lulan Chen, Li Wan, Zheng Wu, Wanting Ren, Yian Huang, Binbin Qian, Yun Wang   +6 more
doaj   +4 more sources

Therapeutic potential for KCC2-targeted neurological diseases

Japanese Dental Science Review, 2023
Patients with neurological diseases, such as schizophrenia, tend to show low K+-Cl- co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation.
Kazuo Tomita, Yoshikazu Kuwahara, Kento Igarashi, Junichi Kitanaka, Nobue Kitanaka, Yuko Takashi, Koh-ichi Tanaka, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Akihiro Kurimasa, Yoshihiro Nishitani, Tomoaki Sato   +11 more
doaj   +4 more sources

KCC2 function modulates in vitro ictogenesis [PDF]

Neurobiology of Disease, 2015
GABAA receptor-mediated inhibition is active and may contribute to epileptiform synchronization. The efficacy of inhibition relies on low levels of intracellular Cl−, which are controlled by KCC2 activity.
Massimo AVOLI, Shabnam Hamidi
exaly   +5 more sources

KCC2 interacts with the dendritic cytoskeleton to promote spine development. [PDF]

Neuron, 2007
The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing.
Coleman, S.K., Lauri, S., Ludwig, A., Cai, C., Airaksinen, M.S., Saarma, M., Keinänen, K., Blaesse, P., Kolikova, J., Afzalov, R., Khiroug, L., Li, H., Kaila, K., Khirug, S., Rivera, C.   +14 more
core   +5 more sources

Phosphoregulation of KCC2 function [PDF]

, 2018
The function of neuronal networks relies on a well-maintained balance between excitation and inhibition, disruption of which can have dramatic pathological impacts on brain function.
Moore, Yvonne Elizabeth Frances
core   +3 more sources

K+/Cl− cotransporter 2 (KCC2) and Na+/HCO3− cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation

Frontiers in Cellular Neuroscience, 2023
K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Abhishek Pethe, Mira Hamze, Marina Giannaki, Bernd Heimrich, Igor Medina, Anna-Maria Hartmann, Anna-Maria Hartmann, Eleni Roussa   +7 more
doaj   +4 more sources

KCC2 is required for the survival of mature neurons but not for their development [PDF]

Journal of Biological Chemistry, 2021
The K+/Cl- co-transporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl- levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABAARs).
Smalley, JL, Kontou, G, Brandon, NJ, Howden, JH, Kittler, JT, Cardarelli, RA, Davies, PA, Ren, Q, Josephine Ng, SF, Dengler, JS, Choi, C, Rodriguez Santos, MA, Moss, SJ, Bope, CE, Kelley, MR   +14 more
core   +5 more sources

Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition [PDF]

eLife, 2017
KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis
Vivek Mahadevan, C Sahara Khademullah, Zahra Dargaei, Jonah Chevrier, Pavel Uvarov, Julian Kwan, Richard D Bagshaw, Tony Pawson, Andrew Emili, Yves De Koninck, Victor Anggono, Matti Airaksinen, Melanie A Woodin   +12 more
doaj   +2 more sources

Molecular architecture of potassium chloride co-transporter KCC2 [PDF]

Scientific Reports, 2017
KCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia.
Deeb, TZ, Agez, M, Brandon, NJ, Jawhari, A, Schultz, P, Medina, I, Cardarelli, RA, Garnier, K, McCall, EJ, Gunnarsson, A, Audebert, S, Frechard, A, Dekker, N, Baker, DJ, Geschwindner, S, Conway, LC, Burnham, MP, Moss, SJ, Wang, Q   +18 more
core   +6 more sources

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation [PDF]

Frontiers in Molecular Neuroscience, 2018
Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan, Liang Ren, Lulan Chen, Guoxiang Wang, Xu Liu, Benjamin H. Wang, Yun Wang   +6 more
doaj   +2 more sources