Results 11 to 20 of about 5,407 (200)
KCC2 downregulation facilitates epileptic seizures [PDF]
Scientific Reports, 2017 GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl− cotransporter-2 (KCC2).
Lulan Chen +6 more
doaj +4 more sources
Therapeutic potential for KCC2-targeted neurological diseases
Japanese Dental Science Review, 2023 Patients with neurological diseases, such as schizophrenia, tend to show low K+-Cl- co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation.
Kazuo Tomita +11 more
doaj +4 more sources
Development of KCC2 therapeutics to treat neurological disorders [PDF]
Frontiers in Molecular NeuroscienceKCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS.
Shilpa D. Kadam, Shane V. Hegarty
doaj +4 more sources
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development [PDF]
Neuron, 2007 The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl(-) transport function, is a key factor in the maturation of dendritic spines.
Li, Hong +14 more
core +4 more sources
KCC2 is required for the survival of mature neurons but not for their development [PDF]
Journal of Biological Chemistry, 2021 The K+/Cl- cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl- levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABAARs). In accordance with this, compromised KCC2 activity results in seizures, but whether such deficits directly ...
Georgina Kontou +14 more
openaire +5 more sources
Frontiers in Cellular Neuroscience, 2023 K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Abhishek Pethe +7 more
doaj +4 more sources
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition [PDF]
eLife, 2017 KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis
Vivek Mahadevan +12 more
doaj +2 more sources
Phosphoregulation of KCC2 function [PDF]
, 2018 The function of neuronal networks relies on a well-maintained balance between excitation and inhibition, disruption of which can have dramatic pathological impacts on brain function.
Moore, Yvonne Elizabeth Frances
openaire +2 more sources
Molecular architecture of potassium chloride co-transporter KCC2 [PDF]
Scientific Reports, 2017 AbstractKCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. Despite significant accumulating data on the biology and electrophysiological properties of KCC2, structure-function relationships ...
Agez, Morgane +18 more
openaire +5 more sources
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation [PDF]
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
doaj +2 more sources