Results 41 to 50 of about 5,407 (200)

Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission [PDF]

The Journal of Neuroscience, 2006
The neuron-specific K+–Cl−cotransporter KCC2 extrudes Cl−and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2 activation is regulated at the transcriptional level and by unknown posttranslational mechanisms.
Peter, Blaesse, Isabelle, Guillemin, Jens, Schindler, Michaela, Schweizer, Eric, Delpire, Leonard, Khiroug, Eckhard, Friauf, Hans Gerd, Nothwang   +7 more
openaire   +2 more sources

Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes

Cell Reports, 2019
Summary: The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling. This raises questions about whether neural processing is comparably altered. Here, we test whether the K+-Cl−
Josiane C.S. Mapplebeck, Louis-Etienne Lorenzo, Kwan Yeop Lee, Cédric Gauthier, Milind M. Muley, Yves De Koninck, Steven A. Prescott, Michael W. Salter   +7 more
doaj   +1 more source

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity [PDF]

Frontiers in Cellular Neuroscience, 2019
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development.
Etienne Côme, Etienne Côme, Etienne Côme, Martin Heubl, Martin Heubl, Martin Heubl, Eric J. Schwartz, Eric J. Schwartz, Eric J. Schwartz, Jean Christophe Poncer, Jean Christophe Poncer, Jean Christophe Poncer, Sabine Lévi, Sabine Lévi, Sabine Lévi   +14 more
openaire   +5 more sources

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Frontiers in Molecular Neuroscience, 2019
GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of ...
Yvonne E. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss, Stephen J. Moss, Stephen J. Moss   +7 more
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

KCC2 membrane diffusion tunes neuronal chloride homeostasis [PDF]

Neuropharmacology, 2020
Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and ...
Côme, Etienne, Marques, Xavier, Poncer, Jean, Lévi, Sabine   +3 more
openaire   +3 more sources

Data_Sheet_1_K+/Cl− cotransporter 2 (KCC2) and Na+/HCO3− cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation.PDF

, 2023
K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Marina Giannaki (17120818), Mira Hamze (17120815), Abhishek Pethe (17120812), Bernd Heimrich (475281), Anna-Maria Hartmann (4183309), Igor Medina (4183303), Eleni Roussa (352756)   +6 more
core   +1 more source

KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Cell Reports, 2019
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila   +5 more
doaj   +1 more source

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

Cell Reports, 2019
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer   +7 more
doaj   +1 more source

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +1 more source