Results 41 to 50 of about 8,156 (210)

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Frontiers in Molecular Neuroscience, 2019
GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of ...
Yvonne E. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss, Stephen J. Moss, Stephen J. Moss   +7 more
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

Frontiers in Cellular Neuroscience, 2011
The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus.
Ilgam eKhalilov, Ilgam eKhalilov, Ilgam eKhalilov, Geneviève eChazal, Geneviève eChazal, Geneviève eChazal, Ilona eChudotvorova, Ilona eChudotvorova, Ilona eChudotvorova, Christophe ePellegrino, Christophe ePellegrino, Christophe ePellegrino, Severine eCorby, Severine eCorby, Severine eCorby, Nadine eFerrand, Nadine eFerrand, Nadine eFerrand, Olena eGubkina, Olena eGubkina, Olena eGubkina, Romain eNardou, Romain eNardou, Romain eNardou, Roman eTyzio, Roman eTyzio, Roman eTyzio, Sumii eYamamoto, Sumii eYamamoto, Sumii eYamamoto, Thomas J Jentsch, Christian eHubner, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Igor eMedina, Igor eMedina, Igor eMedina   +40 more
doaj   +1 more source

A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells [PDF]

, 2017
Background: Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K-Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression in mammals.
Ludwig, Anastasia, Rivera Baeza, Claudio, Uvarov, Pavel   +2 more
core   +2 more sources

KCC2 escape from neuropathic pain [PDF]

Science-Business eXchange, 2013
Researchers from Laval University have described an activator of the co-transporter KCC2 and shown its analgesic effect in mice. The group is developing next-generation compounds with better pharmacological properties.
openaire   +1 more source

Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]

, 2009
During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan, Ben-Ari, Ben-Ari, Bettler, Bi, Blaesse, Carter, Cherubini, Davies, Delpire, Dutar, Fiumelli, Fujikawa, Galanopoulou, Ganguly, Gähwiler, Harrison, Hübner, Kahle, Kanaka, Kanaumi, Khazipov, Lambert, Leinekugel, Leinekugel, Leinekugel, Liu, Lu, Mynlieff, Newberry, Nuñez, Owens, Payne, Pfrieger, Plotkin, Rissman, Rivera, Scholz, Shen, Siebler, Stein, Takahashi, Thompson, Vicario-Abejón, Wang, Wu, Yan, Yu, Yuste   +48 more
core   +2 more sources

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity [PDF]

Frontiers in Cellular Neuroscience, 2019
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development.
Etienne Côme, Etienne Côme, Etienne Côme, Martin Heubl, Martin Heubl, Martin Heubl, Eric J. Schwartz, Eric J. Schwartz, Eric J. Schwartz, Jean Christophe Poncer, Jean Christophe Poncer, Jean Christophe Poncer, Sabine Lévi, Sabine Lévi, Sabine Lévi   +14 more
openaire   +5 more sources

Diminished KCC2 confounds synapse specificity of LTP during senescence [PDF]

Nature Neuroscience, 2016
The synapse specificity of long-term potentiation (LTP) ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21-28 months) mice, LTP was relayed to unstimulated synapses, blemishing its synapse specificity.
Ferando, Isabella, Faas, Guido, Mody, Istvan   +2 more
openaire   +2 more sources

KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Cell Reports, 2019
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila   +5 more
doaj   +1 more source

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +1 more source