Results 41 to 50 of about 5,952 (193)

The KCl‐cotransporter KCC2 linked to epilepsy [PDF]

The EMBO Reports, 2014
In the mature brain, the neurotransmitter GABA can cause a postsynaptic hyperpolarization via activation of chloride permeant GABAA receptor channels. This hyperpolarizing response critically depends on chloride extrusion via the KCl-cotransporter KCC2 1.
openaire   +2 more sources

Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission [PDF]

The Journal of Neuroscience, 2006
The neuron-specific K+–Cl−cotransporter KCC2 extrudes Cl−and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2 activation is regulated at the transcriptional level and by unknown posttranslational mechanisms.
Peter, Blaesse, Isabelle, Guillemin, Jens, Schindler, Michaela, Schweizer, Eric, Delpire, Leonard, Khiroug, Eckhard, Friauf, Hans Gerd, Nothwang   +7 more
openaire   +2 more sources

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

Frontiers in Cellular Neuroscience, 2011
The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus.
Ilgam eKhalilov, Ilgam eKhalilov, Ilgam eKhalilov, Geneviève eChazal, Geneviève eChazal, Geneviève eChazal, Ilona eChudotvorova, Ilona eChudotvorova, Ilona eChudotvorova, Christophe ePellegrino, Christophe ePellegrino, Christophe ePellegrino, Severine eCorby, Severine eCorby, Severine eCorby, Nadine eFerrand, Nadine eFerrand, Nadine eFerrand, Olena eGubkina, Olena eGubkina, Olena eGubkina, Romain eNardou, Romain eNardou, Romain eNardou, Roman eTyzio, Roman eTyzio, Roman eTyzio, Sumii eYamamoto, Sumii eYamamoto, Sumii eYamamoto, Thomas J Jentsch, Christian eHubner, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Jean-Luc eGaiarsa, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Yehezkel eBen-Ari, Igor eMedina, Igor eMedina, Igor eMedina   +40 more
doaj   +1 more source

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity [PDF]

Frontiers in Cellular Neuroscience, 2019
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development.
Etienne Côme, Etienne Côme, Etienne Côme, Martin Heubl, Martin Heubl, Martin Heubl, Eric J. Schwartz, Eric J. Schwartz, Eric J. Schwartz, Jean Christophe Poncer, Jean Christophe Poncer, Jean Christophe Poncer, Sabine Lévi, Sabine Lévi, Sabine Lévi   +14 more
openaire   +5 more sources

Intracellular zinc inhibits KCC2 transporter activity [PDF]

Nature Neuroscience, 2009
We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons.
Michal, Hershfinkel, Karl, Kandler, Megan E, Knoch, Michal, Dagan-Rabin, Mandar A, Aras, Chen, Abramovitch-Dahan, Israel, Sekler, Elias, Aizenman   +7 more
openaire   +2 more sources

KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Cell Reports, 2019
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila   +5 more
doaj   +1 more source

Data_Sheet_1_K+/Cl− cotransporter 2 (KCC2) and Na+/HCO3− cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation.PDF

, 2023
K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Marina Giannaki (17120818), Mira Hamze (17120815), Abhishek Pethe (17120812), Bernd Heimrich (475281), Anna-Maria Hartmann (4183309), Igor Medina (4183303), Eleni Roussa (352756)   +6 more
core   +1 more source

Mechanisms of Inhibitory Synaptic Plasticity: The Regulation of KCC2 [PDF]

, 2014
The mechanisms that regulate the activity of the neuron specific K+Cl- cotransporter (KCC2) remain poorly understood, despite the critical importance of this transporter in inhibitory synaptic transmission and plasticity.
Acton, Brooke Ashley
core   +2 more sources

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

Cell Reports, 2019
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer   +7 more
doaj   +1 more source

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

Neurobiology of Disease, 2020
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV.
Aaron J. Barbour, Kurt F. Hauser, A. Rory McQuiston, Pamela E. Knapp   +3 more
doaj   +1 more source