Results 61 to 70 of about 5,952 (193)

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Frontiers in Cellular Neuroscience, 2015
Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D Merner, Madison R Chandler, Cynthia eBourassa, Bo eLiang, Arjun R Khanna, Patrick eDion, Guy eRouleau, Kristopher eKahle   +7 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

KCC2 Antibody Specificity in Rat.

, 2015
Expression of K-Cl cotransporter (KCC2) in rat prefrontal cortex with varying protein concentration (5 μg, 10 μg, 20 μg). Two different antibodies gave similar bands for KCC2 at the predefined molecular weight (123–126 kDa) (A).
Courtney R. Sullivan (715337), Robert E. McCullumsmith (319486), Dan Shan (715339), Vahram Haroutunian (23823), Adam J. Funk (715338)   +4 more
core   +1 more source

Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity

eLife, 2019
Up-regulation of the persistent sodium current (INaP) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here identified calpain as the driver of the up- and down-regulation of INaP and KCC2,
Vanessa Plantier, Irene Sanchez-Brualla, Nejada Dingu, Cécile Brocard, Sylvie Liabeuf, Florian Gackière, Frédéric Brocard   +6 more
doaj   +1 more source

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
doaj   +1 more source

Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

Frontiers in Molecular Neuroscience, 2022
Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission
Michele Yeo, Qiaojuan Zhang, LeAnne Ding, Xiangjun Shen, Yong Chen, Wolfgang Liedtke   +5 more
doaj   +1 more source

The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice

Data in Brief, 2016
K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative diseases.
Takao Tsukahara, Masaaki Masuhara, Haruki Iwai, Takahiro Sonomura, Tomoaki Sato   +4 more
doaj   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

HBQ1 Acts as a Prognostic Biomarker and Tumor Suppressor Linked to Antigen Presentation in Glioma

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Glioma is a highly aggressive brain tumor associated with substantial morbidity and mortality and with limited treatment options. This study investigates the functional role of Hemoglobin Subunit Theta 1 (HBQ1) in glioma and evaluates its potential as a prognostic biomarker. Using integrated bioinformatics approaches, we demonstrated that HBQ1
Cheng Xie, Qinglin Zhong, Mingang Zou, Qianliang Huang, Lukui Chen, Wenjin Wei   +5 more
wiley   +1 more source

INSIGHTS INTO THE EFFECTS OF KCC2 MODULATION ON EPILEPTIFORM ACTIVITY

, 2021
KCC2 is a K+-Cl- cotransporter with neuronal expression throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and Rett ...
Prael III, Francis Joseph
core