Results 61 to 70 of about 5,407 (200)
Frontiers in Cellular Neuroscience, 2015 Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D Merner +7 more
doaj +1 more source
Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
wiley +1 more source
KCC2 Antibody Specificity in Rat.
, 2015 Expression of K-Cl cotransporter (KCC2) in rat prefrontal cortex with varying protein concentration (5 μg, 10 μg, 20 μg). Two different antibodies gave similar bands for KCC2 at the predefined molecular weight (123–126 kDa) (A).
Courtney R. Sullivan (715337) +4 more
core +1 more source
eLife, 2019 Up-regulation of the persistent sodium current (INaP) and down-regulation of the potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here identified calpain as the driver of the up- and down-regulation of INaP and KCC2,
Vanessa Plantier +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission
Michele Yeo +5 more
doaj +1 more source
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, EarlyView.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice
Data in Brief, 2016 K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative diseases.
Takao Tsukahara +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus +11 more
wiley +1 more source
INSIGHTS INTO THE EFFECTS OF KCC2 MODULATION ON EPILEPTIFORM ACTIVITY
, 2021 KCC2 is a K+-Cl- cotransporter with neuronal expression throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and Rett ...
Prael III, Francis Joseph
core
Sexually dimorphic expression of KCC2 and GABA function [PDF]
Epilepsy Research, 2008 GABA(A) receptors have an age-adapted function in the brain. During early development, they mediate depolarizing effects, which result in activation of calcium-sensitive signaling processes that are important for the differentiation of the brain.
openaire +2 more sources