Results 71 to 80 of about 5,952 (193)

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +1 more source

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source

KCC2 : de la physiologie à la pathologie

, 2023
Cette thèse explore le rôle de KCC2 dans la séquence GABAergique au cours du développement et son implication dans les troubles neurodéveloppementaux (TND). Deux questions clés sont abordées : (1) Comment KCC2 est-il régulé au cours du développement, et (
Hamze, Mira
core  

KCC2 drives chloride microdomain formation in dendritic blebbing

Cell Reports, 2022
Intracellular chloride ion concentration ([Cl-]i) homeostasis is critical for excitatory/inhibitory balance and volume regulation in neurons. We quantitatively map spatiotemporal dendritic [Cl-]i dynamics during N-methyl-d-aspartate (NMDA) excitotoxicity to determine how Cl- changes contribute to localized dendritic swelling (blebbing) in stroke-like ...
Nicholas L. Weilinger, Leigh E. Wicki-Stordeur, Christopher J. Groten, Jeffrey M. LeDue, Kristopher T. Kahle, Brian A. MacVicar   +5 more
openaire   +2 more sources

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Baseline Dynamics and Sleep Loss–Driven Changes of Electrocorticographic Aperiodic Properties Are Altered in Mice Lacking Neuroligin‐2

European Journal of Neuroscience, Volume 64, Issue 6, September 2026.
The current study used a wavelet‐leaders formalism to explore the role of Neuroligin‐2, a key protein of gamma‐aminobutyric acid (GABA)‐ergic synapses, in modulating the spectral power decay of electrocorticographic activity during wake and sleep states.
Tanya Leduc, Janine El Helou, Erika Bélanger‐Nelson, Clément Bourguignon, Jean‐Marc Lina, Valérie Mongrain   +5 more
wiley   +1 more source

Mechanisms of KCC2 upregulation during development [PDF]

, 2008
Gamma-aminobutyric acid (GABA) acting through ionotropic GABAA receptors plays a crucial role in the activity of the central nervous system (CNS). It triggers Ca2+ rise providing trophic support in developing neurons and conducts fast inhibitory function
Ludwig, Anastasia
core  

Sexually dimorphic expression of KCC2 and GABA function [PDF]

Epilepsy Research, 2008
GABA(A) receptors have an age-adapted function in the brain. During early development, they mediate depolarizing effects, which result in activation of calcium-sensitive signaling processes that are important for the differentiation of the brain.
openaire   +2 more sources

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Frontiers in Molecular Neuroscience
IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Claudio Rivera, Anastasia Ludwig   +12 more
doaj   +1 more source

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

The Journal of Physiology, Volume 604, Issue 16, Page 6731-6751, 15 August 2026.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus, Praveen Kumar, Kelly Kneale, T. Noah Hutson, Nicole M. Gautier‐Hall, Deng‐Shan Shiau, Megan Watts, Krystle Trosclair, Hemangini A. Dhaibar, Paari Dominic, Leonidas Iasemidis, Edward Glasscock   +11 more
wiley   +1 more source