Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer’s disease therapy [PDF]
Frontiers in PharmacologyEye movement deficits, including abnormal saccades and impaired smooth pursuits, are among the earliest observable indicators of neurodegenerative diseases, particularly Alzheimer’s disease (AD).
Igor Medina +2 more
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Editorial: Chloride homeostasis in animal cell physiology [PDF]
Frontiers in Physiology, 2023 Jinwei Zhang +2 more
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Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride Homeostasis via Upregulation KCC2 Expression and Function [PDF]
Frontiers in Pharmacology, 2022 Oxytocin (OT) and its receptor are promising targets for the treatment and prevention of the neuropathic pain. In the present study, we compared the effects of a single and continuous intrathecal infusion of OT on nerve injury-induced neuropathic pain ...
Xiyuan Ba +11 more
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Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain [PDF]
Frontiers in Physiology, 2021 In the early stages of the central nervous system growth and development, γ-aminobutyric acid (GABA) plays an instructive trophic role for key events including neurogenesis, migration, synaptogenesis, and network formation.
Mira Hamze +11 more
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Glial Chloride Homeostasis Under Transient Ischemic Stress [PDF]
Frontiers in Cellular Neuroscience, 2021 High water permeabilities permit rapid adjustments of glial volume upon changes in external and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–]int) and glial cell swelling are often assumed to represent early ...
Miriam Engels +10 more
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Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway [PDF]
Cells, 2023 An upregulation of the Na+-K+-2Cl− cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABAARs) and, thus, to hyperactivity.
Etienne Côme +4 more
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Chloride Homeostasis in Neuronal Disorders: Bridging Measurement to Therapy [PDF]
LifeNeuronal chloride (Cl−) homeostasis is fundamental for brain function, with disruptions increasingly recognized as pathogenic across neurological disorders.
Daniele Arosio, Carlo Musio
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How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders [PDF]
Frontiers in Molecular Neuroscience, 2022 Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui +5 more
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The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice [PDF]
Frontiers in Cellular Neuroscience, 2021 Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused mainly by mutations in the MECP2 gene. Mouse models of RTT show reduced expression of the cation-chloride cotransporter KCC2 and altered chloride homeostasis at presymptomatic stages ...
Yasmine Belaïdouni +8 more
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PLoS ONE, 2013 BackgroundAltered chloride homeostasis has been thought to be a risk factor for several brain disorders, while less attention has been paid to its role in liver disease.
Yayun Wang, Yan-Yan Wei, Ke-Feng Dou
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