Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure. [PDF]
Circ Heart Fail, 2016 Background— The aim of this analysis was to determine the long-term prognostic value of lower serum chloride in patients with stable chronic heart failure. Electrolyte abnormalities are prevalent in patients with chronic heart failure. Little is known regarding the prognostic implications of lower serum chloride.
Grodin JL +5 more
europepmc +5 more sources
Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus [PDF]
Molecular Brain, 2020 The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks ...
Camille Dumon +5 more
doaj +2 more sources
Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy [PDF]
The Journal of Neuroscience, 2007 Changes in chloride (Cl−) homeostasis may be involved in the generation of some epileptic activities. In this study, we asked whether Cl−homeostasis, and thus GABAergic signaling, is altered in tissue from patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis.
Gilles, Huberfeld +6 more
openaire +4 more sources
Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus. [PDF]
Sci Rep, 2018 AbstractThe thalamus is important for sensory integration with the ventrobasal thalamus (VB) as relay controlled by GABAergic projections from the nucleus reticularis thalami (NRT). Depending on the [Cl−]i primarily set by cation-chloride-cotransporters, GABA is inhibitory or excitatory. There is evidence that VB and NRT differ in terms of GABA action,
Schmidt T +6 more
europepmc +5 more sources
Development and regulation of chloride homeostasis in the central nervous system. [PDF]
Front Cell Neurosci, 2015 γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the mature central nervous system (CNS). The developmental switch of GABAergic transmission from excitation to inhibition is induced by changes in Cl(-) gradients, which are generated by cation-Cl(-) co-transporters.
Watanabe M, Fukuda A.
europepmc +5 more sources
Pharmacological modulation of chloride channels as a therapeutic strategy for neurological disorders
Frontiers in Physiology, 2023 Chloride homeostasis is critical in the physiological functions of the central nervous system (CNS). Its concentration is precisely regulated by multiple ion-transporting proteins such as chloride channels and transporters that are widely distributed in ...
Zhiyu Wang, Kaylee Choi
doaj +1 more source
When Are Depolarizing GABAergic Responses Excitatory?
Frontiers in Molecular Neuroscience, 2021 The membrane responses upon activation of GABA(A) receptors critically depend on the intracellular Cl− concentration ([Cl−]i), which is maintained by a set of transmembrane transporters for Cl−.
Werner Kilb
doaj +1 more source
Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions [PDF]
, 2013 Peer reviewedPublisher ...
Akmakjian, Garo +12 more
core +13 more sources
SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination [PDF]
, 2016 Chloride homeostasis determines the impact of inhibitory synaptic transmission and thereby mediates the excitability of neurons. Even though cerebellar Purkinje cells (PCs) receive a pronounced inhibitory GABAergic input from stellate and basket cells ...
Barone, S. (Sharon) +8 more
core +4 more sources
Cells, 2023 Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous
Erwan Pol +8 more
doaj +1 more source