Results 31 to 40 of about 839,045 (255)

The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs

eLife, 2020
As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Dominant
Ryan S Phillips, Ian Rosner, Aryn H Gittis, Jonathan E Rubin   +3 more
doaj   +1 more source

WNK3 kinase maintains neuronal excitability by reducing inwardly rectifying K+ conductance in layer V pyramidal neurons of mouse medial prefrontal cortex

Frontiers in Molecular Neuroscience, 2022
The with-no-lysine (WNK) family of serine-threonine kinases and its downstream kinases of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress-responsive kinase-1 (OSR1) may regulate intracellular Cl− homeostasis through ...
Adya Saran Sinha, Tianying Wang, Miho Watanabe, Yasushi Hosoi, Eisei Sohara, Tenpei Akita, Shinichi Uchida, Atsuo Fukuda   +7 more
doaj   +1 more source

TGF-β2 Regulates Transcription of the K⁺/Cl⁻ Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons

Cells, 2022
KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated.
Anastasia Rigkou, Attila Magyar, Jan Manuel Speer, Eleni Roussa   +3 more
doaj   +1 more source

Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus. [PDF]

Sci Rep, 2018
AbstractThe thalamus is important for sensory integration with the ventrobasal thalamus (VB) as relay controlled by GABAergic projections from the nucleus reticularis thalami (NRT). Depending on the [Cl−]i primarily set by cation-chloride-cotransporters, GABA is inhibitory or excitatory. There is evidence that VB and NRT differ in terms of GABA action,
Schmidt T, Ghaffarian N, Philippot C, Seifert G, Steinhäuser C, Pape HC, Blaesse P.   +6 more
europepmc   +5 more sources

The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines

Frontiers in Cellular Neuroscience, 2020
Kainate receptors (KAR) play a crucial role in the plasticity and functional maturation of glutamatergic synapses. However, how they regulate structural plasticity of dendritic spines is not known.
Sebnem Kesaf, Sebnem Kesaf, Stanislav Khirug, Emilie Dinh, Marta Saez Garcia, Shetal Soni, Ester Orav, Ester Orav, Eric Delpire, Tomi Taira, Tomi Taira, Sari E. Lauri, Sari E. Lauri, Claudio Rivera, Claudio Rivera   +14 more
doaj   +1 more source

Nucleus-Specific Chloride Homeostasis in Rat Thalamus [PDF]

The Journal of Neuroscience, 1997
Synchronous thalamic network activity occurring during slow wave sleep and paroxysmal discharges critically depends on the ability of thalamocortical relay cells and inhibitory neurons of the nucleus reticularis thalami (nRt) to fire bursts of action potentials.
D, Ulrich, J R, Huguenard
openaire   +2 more sources

Cellular Physiology and Pathophysiology of EAAT Anion Channels

Frontiers in Cellular Neuroscience, 2022
Excitatory amino acid transporters (EAATs) optimize the temporal resolution and energy demand of mammalian excitatory synapses by quickly removing glutamate from the synaptic cleft into surrounding neuronal and glial cells and ensuring low resting ...
Peter Kovermann, Miriam Engels, Frank Müller, Christoph Fahlke   +3 more
doaj   +1 more source

Development of the Chloride Homeostasis in the Auditory Brainstem

Physiological Research, 2011
Inhibitory neurotransmission plays a substantial role in encoding of auditory cues relevant for sound localization in vertebrates. While the anatomical organization of the respective afferent auditory brainstem circuits shows remarkable similarities between mammals and birds, the properties of inhibitory neurotransmission in these neural circuits are ...
I, Milenković, R, Rübsamen
openaire   +2 more sources

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity

Frontiers in Cellular Neuroscience, 2019
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs).
Etienne Côme, Etienne Côme, Etienne Côme, Martin Heubl, Martin Heubl, Martin Heubl, Eric J. Schwartz, Eric J. Schwartz, Eric J. Schwartz, Jean Christophe Poncer, Jean Christophe Poncer, Jean Christophe Poncer, Sabine Lévi, Sabine Lévi, Sabine Lévi   +14 more
doaj   +1 more source

NKCC1-deficiency results in abnormal proliferation of neural progenitor cells of the lateral ganglionic eminence

Frontiers in Cellular Neuroscience, 2016
The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter NKCC1 is important for regulating cell volume and the proliferation of different cell types in vitro.
Ana Cathia Magalhães, Claudio Rivera, Claudio Rivera, Claudio Rivera   +3 more
doaj   +1 more source