The Arabidopsis thylakoid chloride channel AtCLCe functions in chloride homeostasis and regulation of photosynthetic electron transport [PDF]
Frontiers in Plant Science, 2016 Chloride ions can be translocated across cell membranes through Cl− channels or Cl−/H+ exchangers. The thylakoid-located member of the Cl− channel CLC family in Arabidopsis thaliana (AtCLCe) was hypothesized to play a role in photosynthetic regulation ...
Andrei eHerdean +6 more
doaj +3 more sources
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome [PDF]
Molecular Therapy, 2021 Anna Rocchi +2 more
exaly +2 more sources
The Alteration of Chloride Homeostasis/GABAergic Signaling in Brain Disorders: Could Oxidative Stress Play a Role? [PDF]
Antioxidants, 2021 Provvidenza Maria Abruzzo +2 more
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Exploring the Role of the SLC12A Cation-Coupled Chloride Cotransporters in the Cardiovascular System [PDF]
CellsCardiomyopathies are a major category of cardiovascular disease, significantly contributing to global morbidity and mortality. Their pathogenesis involves a complex interplay of genetic and environmental factors, with multiple gene families playing ...
Adriana Mercado +3 more
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Implication of 5-HT in the Dysregulation of Chloride Homeostasis in Prenatal Spinal Motoneurons from the G93A Mouse Model of Amyotrophic Lateral Sclerosis [PDF]
International Journal of Molecular Sciences, 2020 Pascal Branchereau +2 more
exaly +2 more sources
Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation–Chloride Cotransporters in Rat Cortical Neurons [PDF]
International Journal of Molecular SciencesIgor Medina +2 more
exaly +2 more sources
Regulation of neuronal chloride homeostasis by neuromodulators. [PDF]
J Physiol, 2016 AbstractKCC2 is the central regulator of neuronal Cl− homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epilepsy, neuropathic pain and neuropsychiatric ...
Mahadevan V, Woodin MA.
europepmc +4 more sources
Pharmacological modulation of chloride channels as a therapeutic strategy for neurological disorders
Frontiers in Physiology, 2023 Chloride homeostasis is critical in the physiological functions of the central nervous system (CNS). Its concentration is precisely regulated by multiple ion-transporting proteins such as chloride channels and transporters that are widely distributed in ...
Zhiyu Wang, Kaylee Choi
doaj +1 more source
When Are Depolarizing GABAergic Responses Excitatory?
Frontiers in Molecular Neuroscience, 2021 The membrane responses upon activation of GABA(A) receptors critically depend on the intracellular Cl− concentration ([Cl−]i), which is maintained by a set of transmembrane transporters for Cl−.
Werner Kilb
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Cells, 2023 Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous
Erwan Pol +8 more
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