Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway [PDF]
Cells, 2023 An upregulation of the Na+-K+-2Cl− cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABAARs) and, thus, to hyperactivity.
Etienne Côme +4 more
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The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice [PDF]
Frontiers in Cellular Neuroscience, 2021 Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused mainly by mutations in the MECP2 gene. Mouse models of RTT show reduced expression of the cation-chloride cotransporter KCC2 and altered chloride homeostasis at presymptomatic stages ...
Yasmine Belaïdouni +8 more
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Chloride transport and homeostasis in plants
Quantitative Plant BiologyThe micronutrient chloride (Cl―) plays key roles in plant physiology, from photosystem II and vacuolar ATPase activity to osmoregulation, turgor maintenance and drought resilience, while also posing toxicity risks at high concentrations.
Harverth Silva-Herrera +5 more
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Regulation of neuronal chloride homeostasis by neuromodulators. [PDF]
J Physiol, 2016 AbstractKCC2 is the central regulator of neuronal Cl− homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epilepsy, neuropathic pain and neuropsychiatric ...
Mahadevan V, Woodin MA.
europepmc +4 more sources
Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2. [PDF]
Nature Neuroscience, 2010 Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells ...
Földy, Csaba +3 more
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Early establishment of chloride homeostasis in CRH neurons is altered by prenatal stress leading to fetal HPA axis dysregulation [PDF]
Frontiers in Molecular NeuroscienceCorticotropin-releasing hormone (CRH) neurons play an important role in the regulation of neuroendocrine responses to stress. The excitability of CRH neurons is regulated by inhibitory GABAergic inputs. However, it is unclear when GABAergic regulation of
Miho Watanabe +3 more
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The Alteration of Chloride Homeostasis/GABAergic Signaling in Brain Disorders: Could Oxidative Stress Play a Role? [PDF]
Antioxidants, 2021 In neuronal precursors and immature neurons, the depolarizing (excitatory) effect of γ-Aminobutyric acid (GABA) signaling is associated with elevated [Cl−]i; as brain cells mature, a developmental switch occurs, leading to the decrease of [Cl−]i and to ...
Provvidenza M. Abruzzo +2 more
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Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer’s disease therapy [PDF]
Frontiers in PharmacologyEye movement deficits, including abnormal saccades and impaired smooth pursuits, are among the earliest observable indicators of neurodegenerative diseases, particularly Alzheimer’s disease (AD).
Christophe Porcher +5 more
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Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels [PDF]
Frontiers in Cellular Neuroscience, 2018 The intraneuronal ionic composition is an important determinant of brain functioning. There is growing evidence that aberrant homeostasis of the intracellular concentration of Cl− ([Cl−]i) evokes, in addition to that of Na+ and Ca2+, robust impairments ...
Negah Rahmati +5 more
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Exercise modulates chloride homeostasis after spinal cord injury. [PDF]
J Neurosci, 2014 Activity-based therapies are routinely integrated in spinal cord injury (SCI) rehabilitation programs because they result in a reduction of hyperreflexia and spasticity. However, the mechanisms by which exercise regulates activity in spinal pathways to reduce spasticity and improve functional recovery are poorly understood.
Côté MP +3 more
europepmc +4 more sources