Glial Chloride Homeostasis Under Transient Ischemic Stress [PDF]
Frontiers in Cellular Neuroscience, 2021 High water permeabilities permit rapid adjustments of glial volume upon changes in external and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–]int) and glial cell swelling are often assumed to represent early ...
Miriam Engels +10 more
doaj +7 more sources
Editorial: Chloride homeostasis in animal cell physiology [PDF]
Frontiers in Physiology, 2023 Jinwei Zhang +6 more
doaj +4 more sources
Chloride Homeostasis in Neuronal Disorders: Bridging Measurement to Therapy [PDF]
LifeNeuronal chloride (Cl−) homeostasis is fundamental for brain function, with disruptions increasingly recognized as pathogenic across neurological disorders.
Daniele Arosio, Carlo Musio
doaj +3 more sources
Star players sidelined in chloride homeostasis in neurons [PDF]
Frontiers in Cellular Neuroscience, 2014 The chloride ion (Cl−) is the most abundant physiological anion and is involved in many cellular functions including intracellular membrane trafficking, volume control, and excitability, as well regulating short- and long-term plasticity in neurons (Woodin et al., 2003; De Koninck, 2007; Raimondo et al., 2012; Succol et al., 2012; Stauber and Jentsch ...
Chang-Hoon eCho
doaj +5 more sources
The Arabidopsis thylakoid chloride channel AtCLCe functions in chloride homeostasis and regulation of photosynthetic electron transport [PDF]
Frontiers in Plant Science, 2016 Chloride ions can be translocated across cell membranes through Cl− channels or Cl−/H+ exchangers. The thylakoid-located member of the Cl− channel CLC family in Arabidopsis thaliana (AtCLCe) was hypothesized to play a role in photosynthetic regulation ...
Andrei eHerdean +6 more
doaj +5 more sources
Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride Homeostasis via Upregulation KCC2 Expression and Function [PDF]
Frontiers in Pharmacology, 2022 Oxytocin (OT) and its receptor are promising targets for the treatment and prevention of the neuropathic pain. In the present study, we compared the effects of a single and continuous intrathecal infusion of OT on nerve injury-induced neuropathic pain ...
Xiyuan Ba +11 more
doaj +2 more sources
Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain [PDF]
Frontiers in Physiology, 2021 In the early stages of the central nervous system growth and development, γ-aminobutyric acid (GABA) plays an instructive trophic role for key events including neurogenesis, migration, synaptogenesis, and network formation.
Mira Hamze +11 more
doaj +2 more sources
Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain [PDF]
Cell Reports, 2016 Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying ...
Lingyong Li +6 more
doaj +5 more sources
How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders [PDF]
Frontiers in Molecular Neuroscience, 2022 Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism spectrum disorders, epilepsy, and schizophrenia.
Kelvin K. Hui +5 more
doaj +2 more sources
KCC2 membrane diffusion tunes neuronal chloride homeostasis [PDF]
Neuropharmacology, 2020 Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and ...
Côme, Etienne +3 more
openaire +5 more sources