Results 1 to 10 of about 82 (65)
A Pan-Cancer Analysis of SLC12A5 Reveals Its Correlations with Tumor Immunity [PDF]
Disease Markers, 2021 Background. Solute carrier family 12 member 5 (SLC12A5) has been reported to play an oncogenic role in certain malignancies. Its prognostic roles and immune mechanisms of action in human cancers, however, remain largely unknown. Methods. Data derived from TCGA, GEPIA, and TIMER databases were utilized to delve into the expressing patterns, prognostic ...
Yi Jiang, Hong-li Liao, Li-ya Chen
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SLC12A5 antibody characterization report
, 2023 This report guides researchers to select the most appropriate antibodies for Solute Carrier Family 12 Member 5. We used an antibody characterization pipeline based on knockout overexpression (KOOE) and knockout (KO) cells to perform head-to-head comparisons of commercial antibodies for SLC12A5 by immunoblot (Western blot) and immunofluorescence.
Garcia, Julio, Gelova, Zuzana
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Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K+-Cl– cotransporter (KCC2) defines a new region of conserved homology [PDF]
Cytogenetic and Genome Research, 2003 K(+)-Cl(-) cotransporters (KCCs) constitute a branch of the cation-chloride cotransporter (CCC) family. To date, four KCC isoforms (KCC1-KCC4) have been identified and they all mediate obligatorily coupled, electroneutral transmembrane movement of K(+) and Cl(-) ions.
R, Sallinen +5 more
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Purification of SLC12A5 from Expi293FTM Cells
, 2022 This protocol is used to purify the SLC transporter expressed in Expi293FTM Cells using detergent solubilization followed by a series of different chromatographic methods. Depending on the nature of the expression construct and experimental requirements, the GFP tag can be removed using a proteolytic reaction.
David B. Sauer +5 more
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Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction
Brain Research, 2019 SLC12A5 encodes K+-Cl- cotransporter 2 (KCC2), which is the main Cl- extruder of neurons, and renders the proper inhibitory function of the neurotransmitters γ-aminobutyric acid (GABA) and glycine. Thus, any variant in SLC12A5, if it causes dysfunction of KCC2, could be pathogenic for neurological and psychiatric disorders by disrupting inhibition and ...
Atsuo Fukuda, Miho Watanabe
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Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia [PDF]
Frontiers in Cellular Neuroscience, 2015 Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic function.
Merner, Nancy D. +7 more
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Allele specific expression in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Allele‐specific expression (ASE), preferential expression of one allele at a heterozygous locus, is implicated in various brain diseases but remains largely uncharacterized in Alzheimer's disease (AD). METHODS We performed a genome‐wide characterization of ASE variants across seven brain regions of 2,231 AD and Control patients ...
Zishan Wang +6 more
wiley +1 more source
Development and validation of MethylCog, a blood DNA methylation proxy for cognition
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea +9 more
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Arteannuin B Inhibits NSCLC Cells via Regulating miR‐194‐3p/CLDN2 Axis
Cancer Medicine, Volume 15, Issue 4, April 2026.Arteannuin B (Art B), a sesquiterpene lactone from Artemisia annua, upregulates miR‐194‐3p, which directly targets two conserved sites (nt 358–365 and 1232–1238) in the CLDN2 3′ UTR. This triggers mRNA decay and blocks translation, suppressing CLDN2 expression.
Ting‐Sha He +9 more
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 8, Page 168-189, December 2025.ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino +8 more
wiley +1 more source