Results 1 to 10 of about 1,461 (124)

Editorial: SLC12A5-dependent neurological disorders [PDF]

Frontiers in Molecular Neuroscience
International ...
Igor Medina, Coralie Di Scala, Claudio Rivera   +2 more
exaly   +7 more sources

Comparison of the Effect of the Combination of Sodium Valproate and Sodium Dichloroacetate on the Expression of SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP in Primary Female Glioblastoma Cells with That of Temozolomide [PDF]

Pharmaceutics
The search for an effective treatment for adult high-grade glioblastoma (GBM) remains urgent. Background/Objectives: The study aimed to determine the expression of carcinogenesis-related genes, such as SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP, in ...
Dovydas Gečys, Laimis Akramas, Aidanas Preikšaitis, Ingrida Balnytė, Arūnas Vaitkevičius, Julija Šimienė, Donatas Stakišaitis   +6 more
doaj   +3 more sources

Differential Impact of Valproic Acid on SLC5A8, SLC12A2, SLC12A5, CDH1, and CDH2 Expression in Adult Glioblastoma Cells [PDF]

Biomedicines
Valproic acid (VPA) has anticancer, anti-inflammatory, and epigenetic effects. The study aimed to determine the expression of carcinogenesis-related SLC5A8, SLC12A2, SLC12A5, CDH1, and CDH2 in adult glioblastoma U87 MG and T98G cells and the effects of 0.
Milda Juknevičienė, Ingrida Balnytė, Angelija Valančiūtė, Marta Marija Alonso, Aidanas Preikšaitis, Kęstutis Sužiedėlis, Donatas Stakišaitis   +6 more
doaj   +4 more sources

The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion

Scientific Reports, 2017
Intracellular chloride concentration ([Cl−]i) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl− loaders such as the Na+K+2Cl− co-transporter 1 (Slc12a2) over Cl−extruders of unidentified ...
Timothy S McMillen, Juliusz Kozak, Abu A Sajib   +2 more
exaly   +5 more sources

Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5 [PDF]

Journal of Cellular and Molecular Medicine
Hepatocellular carcinoma (HCC) presents a persistent challenge to conventional therapeutic approaches. SLC12A5 is implicated in an oncogenic capacity and facilitates the progression of cancer.
Ceyhan Hacıoğlu
exaly   +4 more sources

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion [PDF]

Frontiers in Molecular Neuroscience
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development. In mature neurons, KCC2 maintains a low enough intracellular chloride concentration essential for inhibitory ...
Viivi Järvelä, Viivi Järvelä, Viivi Järvelä, Mira Hamze, Jonna Komulainen-Ebrahim, Jonna Komulainen-Ebrahim, Jonna Komulainen-Ebrahim, Elisa Rahikkala, Elisa Rahikkala, Elisa Rahikkala, Johanna Piispala, Mika Kallio, Salla M. Kangas, Salla M. Kangas, Tereza Nickl, Tereza Nickl, Tereza Nickl, Marko Huttula, Reetta Hinttala, Reetta Hinttala, Reetta Hinttala, Johanna Uusimaa, Johanna Uusimaa, Johanna Uusimaa, Igor Medina, Esa-Ville Immonen, Esa-Ville Immonen, Esa-Ville Immonen   +27 more
doaj   +4 more sources

Different Effects of Valproic Acid on SLC12A2, SLC12A5 and SLC5A8 Gene Expression in Pediatric Glioblastoma Cells as an Approach to Personalised Therapy

Biomedicines, 2022
Valproic acid (VPA) is a histone deacetylase inhibitor with sex-specific immunomodulatory and anticancer effects. This study aimed to investigate the effect of 0.5 and 0.75 mM VPA on NKCC1 (SLC12A2), KCC2 (SLC12A5) and SLC5A8 (SLC5A8) co-transporter gene
Eligija Damanskienė, Ingrida Balnytė, Angelija Valančiūtė, Marta Marija Alonso, Donatas Stakišaitis   +4 more
doaj   +2 more sources

SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes

Cancer Medicine, 2023
Background Hepatocellular carcinoma (HCC) has a poor prognosis and new effective treatments are needed. SLC12A5 plays important roles in multiple complex pathological states and is overexpressed in a variety of malignancies.
Qing Tong, Yuan Chu
exaly   +2 more sources

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2-developmental and epileptic encephalopathy. [PDF]

Epilepsia
International audienceThis study was undertaken to characterize the functional impact of novel SLC12A5 variants in two unrelated patients with early onset developmental and epileptic encephalopathy (DEE) and to investigate the mechanisms underlying KCC2 ...
Hamze M, Whitney R, Ville D, Villeneuve N, Hartmann AM, Becker L, Hausmann J, Zhang J, Brier C, Pisella LI, Friedel P, Labalme A, Alix E, Chatron N, Sanlaville D, Gory-Fauré S, Denarier E, Porcher C, Lesca G, Medina I.   +19 more
europepmc   +2 more sources

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures [PDF]

Nature Communications, 2015
The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions.
Robert J. Harvey, Dimitri Kullmann, Atsuo Kawahara   +2 more
exaly   +3 more sources