Results 1 to 10 of about 1,113 (145)

SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes

Cancer Medicine, 2023
Background Hepatocellular carcinoma (HCC) has a poor prognosis and new effective treatments are needed. SLC12A5 plays important roles in multiple complex pathological states and is overexpressed in a variety of malignancies.
Qing Tong
exaly   +4 more sources

The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion [PDF]

Scientific Reports, 2017
Intracellular chloride concentration ([Cl−]i) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl− loaders such as the Na+K+2Cl− co-transporter 1 (Slc12a2) over Cl−extruders of unidentified ...
Mauricio Di Fulvio, Abu A Sajib
exaly   +4 more sources

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion

Frontiers in Molecular Neuroscience
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development. In mature neurons, KCC2 maintains a low enough intracellular chloride concentration essential for inhibitory ...
Igor Medina, Mika Kallio
exaly   +5 more sources

Editorial: SLC12A5-dependent neurological disorders

Frontiers in Molecular Neuroscience
Non peer ...
Claudio Rivera
exaly   +6 more sources

Different Effects of Valproic Acid on SLC12A2, SLC12A5 and SLC5A8 Gene Expression in Pediatric Glioblastoma Cells as an Approach to Personalised Therapy

Biomedicines, 2022
Valproic acid (VPA) is a histone deacetylase inhibitor with sex-specific immunomodulatory and anticancer effects. This study aimed to investigate the effect of 0.5 and 0.75 mM VPA on NKCC1 (SLC12A2), KCC2 (SLC12A5) and SLC5A8 (SLC5A8) co-transporter gene
Eligija Damanskienė, Ingrida Balnytė, Angelija Valančiūtė, Marta Marija Alonso, Donatas Stakišaitis   +4 more
doaj   +4 more sources

Epilepsy of Infancy With Migrating Focal Seizures

Annals of the Child Neurology Society
Annals of the Child Neurology Society, Volume 3, Issue 2, Page 125-126, June 2025.
Samuel Kamoroff, Harry Abram, Fernando Galan   +2 more
wiley   +2 more sources

Epigenetic Clock in Bears: A Simple Cost‐Effective Blood DNA Methylation‐Based Age Estimation Method Applicable to Multiple Bear Species

Ecology and Evolution, Volume 15, Issue 5, May 2025.
Age is an essential factor to understand the life history and demographic parameters of wildlife. In this study, we built a common epigenetic clock model for multiple bear species, including brown, Asian black, polar, sun, and Andean bears. The model will contribute to ecological research, conservation, and management of bear species.
Michito Shimozuru, Shiori Nakamura, Jumpei Yamazaki, Yojiro Yanagawa, Hiroo Tamatani, Misako Kuroe, Koji Yamazaki, Shinsuke Koike, Yusuke Goto, Tomoko Naganuma, Kahoko Tochigi, Akino Inagaki, Naoki Takekoshi, Seungyun Baek, Nobutaka Sato, Yusuke Honda, Toshio Tsubota, Hideyuki Ito   +17 more
wiley   +2 more sources

Family History of Hypertension Predicts Thyroid Cancer Risk in Women: A Population‐Based Cross‐Sectional Study With Integrative Machine Learning and Genomic Analyses

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Introduction Thyroid cancer is one of the most common endocrine malignancies globally, with a markedly higher incidence in women. Although pregnancy‐induced hypertension is recognized as a risk factor, the underlying mechanisms linking hypertension and thyroid cancer remain poorly understood.
Zijin Wang, Yanhui Lin, Fanke Meng, Yuxin Sun, Ziran Zhang, Tong Wu, Min Fu, Fanye Wu, Zhengran Li, Zejun Chen   +9 more
wiley   +2 more sources

A potassium-chloride co-transporter promotes tumor progression and castration resistance of prostate cancer through m6A reader YTHDC1

Cell Death and Disease, 2023
SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported to promote tumor progression, however, the underlying mechanism remains unclear.
Shuai Yuan, Shao-Hua He, Lu-Yao Li, Shu Xi, Hong Weng, Jin-Hui Zhang, Dan-Qi Wang, Meng-Meng Guo, Haozhe Zhang, Shuang-Ying Wang, Dao-Jing Ming, Meng-Yang Liu, Hailiang Hu, Xian-Tao Zeng   +13 more
doaj   +1 more source

When Are Depolarizing GABAergic Responses Excitatory?

Frontiers in Molecular Neuroscience, 2021
The membrane responses upon activation of GABA(A) receptors critically depend on the intracellular Cl− concentration ([Cl−]i), which is maintained by a set of transmembrane transporters for Cl−.
Werner Kilb
doaj   +1 more source