Results 41 to 50 of about 82 (65)
Overexpression of SLC12A5 is associated with tumor progression and poor survival in ovarian carcinoma [PDF]
International Journal of Gynecological Cancer, 2019 The solute carrier family 12 member 5 (SLC12A5) gene is playing a putative oncogenic role in colorectal carcinoma. However, the status of SLC12A5 amplification and expression in ovarian carcinoma and its potential clinical and/or prognostic significance has not yet been investigated.In the present study, semi-quantitative staining and fluorescence in ...
Feng-Wei Wang, Hong-Wei Shen, Dan Xie
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SLC12A5 as a novel potential biomarker of glioblastoma multiforme
Molecular Biology Reports, 2023Glioblastoma multiforme (GBM) is the most prevalent and malignant intracranial tumor with significant features of dismal prognosis and limited therapeutic solutions. Consequently, the present studies are committed to exploring potential biomarkers through bioinformatics analysis, which may serve as valuable prognostic predictors or novel therapeutic ...
Jiakai Chen +3 more
openaire +2 more sources
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures [PDF]
Nature Communications, 2015 AbstractThe potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions. KCC2 dysfunction has been implicated in human epilepsy, but to date, no monogenic KCC2-related epilepsy disorders have been described.
Tommy Stödberg +2 more
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Editorial: SLC12A5-dependent neurological disorders
Frontiers in Molecular NeuroscienceNon peer ...
Igor Medina +2 more
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Biomedicines, 2022 Valproic acid (VPA) is a histone deacetylase inhibitor with sex-specific immunomodulatory and anticancer effects. This study aimed to investigate the effect of 0.5 and 0.75 mM VPA on NKCC1 (SLC12A2), KCC2 (SLC12A5) and SLC5A8 (SLC5A8) co-transporter gene expressions in pediatric PBT24 (boy’s) and SF8628 (girl’s) glioblastoma cells. The SLC12A2, SLC12A5
Ingrīda Balnytė +2 more
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The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion [PDF]
Scientific Reports, 2017 AbstractIntracellular chloride concentration ([Cl−]i) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl− loaders such as the Na+K+2Cl− co-transporter 1 (Slc12a2) over Cl−extruders of unidentified nature.
Timothy S Mcmillen +2 more
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A variant in SLC12A5 for a familial benign Rolandic epilepsy
Neurology Asia, 2023Benign Rolandic epilepsy (BRE) is the most common cause of epilepsy in childhood. Childhood epilepsies have high heritability, and many BRE cases show an autosomal dominant inheritance pattern. Thanks to the advancement of genomics, the causal genes of BRE were being elucidated.
JONG HUN Kim, Hyoung Seop Kim
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Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders [PDF]
Journal of Neuroscience, 2012 The neuron-specific K+-Cl−cotransporter SLC12A5, also known as KCC2, helps mediate the electrophysiological effects of GABA. The pattern of KCC2 expression during early brain development suggests that its upregulation drives the postsynaptic switch of GABA from excitation to inhibition.
Tianzhang Ye +2 more
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Sequence Variation Associated with SLC12A5 Gene Expression Is Linked to Brain Structure and Function in Healthy Adults [PDF]
Cerebral Cortex, 2019 Abstract A single-nucleotide polymorphism in the promoter region of the Matrix Metalloproteinase-9 (MMP9) gene, rs3918242, has been shown to affect MMP9 expression in macrophages and was associated with schizophrenia by two independent groups.
Michael D Gregory +2 more
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Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay [PDF]
Scientific Reports, 2016 AbstractEpilepsy of infancy with migrating focal seizures (EIMFS) is one of the early-onset epileptic syndromes characterized by migrating polymorphous focal seizures. Whole exome sequencing (WES) in ten sporadic and one familial case of EIMFS revealed compound heterozygous SLC12A5 (encoding the neuronal K+-Cl− co-transporter KCC2) mutations in two ...
Hirotomo Saitsu +2 more
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