Results 41 to 50 of about 1,526 (158)
Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats [PDF]
, 2023 The mechanisms of treatment-resistant depression (TRD) are not clear and are difficult to study. An animal model resembling human TRD is the Wistar Kyoto rat strain.
Pabian, Paulina +6 more
core +1 more source
Frontiers in Cellular Neuroscience, 2019 Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures thought to arise from impaired balance between neuronal excitation and inhibition.
Phan Q. Duy +7 more
doaj +1 more source
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission
Scientific Reports, 2017 The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations ...
Anna Doshina +12 more
doaj +1 more source
BMC Cardiovascular Disorders, 2023 Aim To evaluate the expression profile of long non-coding RNAs (lncRNAs) in calcific aortic valve disease (CAVD) and explore their potential mechanism of action.
Guang-Yuan Song +8 more
doaj +1 more source
Frontiers in Genetics, 2021 Pathological neovascularization in choroid, a leading cause of blindness, is a characteristic of many fundus diseases, such as diabetic retinopathy and age-related macular degeneration.
Jie Jia +11 more
doaj +1 more source
Cells, 2020 Androgen deprivation therapy (ADT) is standard-of-care for advanced-stage prostate cancer, and enzalutamide (Xtandi®, Astellas, Northbrook, IL, USA), a second generation antiandrogen, is prescribed in this clinical setting.
Shiv Verma +3 more
doaj +1 more source
Development and validation of MethylCog, a blood DNA methylation proxy for cognition
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea +9 more
wiley +1 more source
DNA Methylation-based Diagnostic and Prognostic Biomarkers for Glioblastoma
Cell Transplantation, 2020 Glioblastomas are the most common primary central nervous system malignancy tumor in adults. Glioblastoma patients have poor prognosis, with an average survival period of approximately 14 mo after diagnosis.
Yunliang Tang +3 more
doaj +1 more source
Arteannuin B Inhibits NSCLC Cells via Regulating miR‐194‐3p/CLDN2 Axis
Cancer Medicine, Volume 15, Issue 4, April 2026.Arteannuin B (Art B), a sesquiterpene lactone from Artemisia annua, upregulates miR‐194‐3p, which directly targets two conserved sites (nt 358–365 and 1232–1238) in the CLDN2 3′ UTR. This triggers mRNA decay and blocks translation, suppressing CLDN2 expression.
Ting‐Sha He +9 more
wiley +1 more source
F1000Research, 2015 Huntington ́s disease (HD) is a progressive, neurodegenerative disease with a fatal outcome. Although the disease-causing gene (huntingtin) has been known for over 20 years, the exact mechanisms leading to neuronal cell death are still controversial. One
Ravi Kiran Reddy Kalathur +4 more
doaj +1 more source