Results 51 to 60 of about 1,526 (158)

Screening of possible biomarkers and therapeutic targets in kidney renal clear cell carcinoma: Evidence from bioinformatic analysis

Frontiers in Oncology, 2022
Renal cell carcinoma (RCC), as one of the most common urological malignancies, has many histologic and molecular subtypes, among which clear cell renal cell carcinoma (ccRCC) is one of the most common causes of tumor-related deaths.
Longfei Peng, Zhangjun Cao, Qi Wang, Lu Fang, Songbai Yan, Dian Xia, Jinyou Wang, Liangkuan Bi   +7 more
doaj   +1 more source

Molecular Determinants of Dorsal Horn Excitability and Pain Processing in Male and Female Rats and Humans

, 2023
While females exhibit higher pain prevalence, pain research has been sex-biased. To address this, we characterized the expression of molecular determinants of a canonical dorsal horn (DH) hyperexcitability pathway across sex.
Khan, Marrium
core   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 8, Page 168-189, December 2025.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Integrated Analysis of the LncRNA‐Mediated ceRNA Network Associated With Prognosis in Posttreatment Recurrent Nasopharyngeal Carcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT The competing endogenous RNA hypothesis offers new insights into tumour progression, yet its role in posttreatment nasopharyngeal carcinoma relapse remains unclear. This study constructed ceRNA networks to identify molecular markers associated with NPC relapse.
Qihong Liu, Jingxiao Lu, Zhiqiang Wang, Qingming Li, Jianhui Wu, Kexing Lyu, Beiping Miao, Wenbin Lei, Guohui Nie, Xiaoqin Fan   +9 more
wiley   +1 more source

Molecular Features of Glioma Determined and Validated Using Combined TCGA and GTEx Data Analyses

Frontiers in Oncology, 2021
Gliomas are among the most common intracranial tumors which originated from neuroepithelial cells. Increasing evidence has revealed that long noncoding RNA (lncRNA)-microRNA (miRNA)-mRNA module regulation and tumor-infiltrating immune cells play ...
Zijiang Yang, Weiyi Gong, Ting Zhang, Heng Gao   +3 more
doaj   +1 more source

A variant of KCC2 from patients with febrile seizures impairs neuronal chloride extrusion and dendritic spine formation [PDF]

, 2014
Data source: Supplementary information, http://embor.embopress.org/content/15/6/723#sec-19Genetic variation in SLC12A5 which encodes KCC2, the neuron-specific cation-chloride cotransporter that is essential for hyperpolarizing GABAergic signaling and ...
Berkovic, S., Vutskits, Laszlo, Berkovic, Samuel F, Iona, X, Dibbens, L., Oliver, Karen L, Blaesse, P., Vutskits, L., Grinton, BE, Puskarjov, M., Ahmad, Faraz, Seja, P, Scheffer, I., Grinton, B., Petrou, S., Grinton, Bronwyn E, Williams, TC, Oliver, KL, Kaila, K., Seja, P., Seja, Patricia, Petrou, S, Scheffer, Ingrid E, Dibbens, LM, Heron, Sarah E, Kaila, Kai, Berkovic, SF, Iona, X., Heron, S., Petrou, Steven, Scheffer, IE, Kaila, K, Ahmad, F, Vutskits, L, Blaesse, P, Iona, Xenia, Heron, SE, Puskarjov, Martin, Blaesse, Peter, Williams, Tristiana C, Williams, T., Ahmad, F., Puskarjov, M, Oliver, K., Dibbens, Leanne M   +44 more
core   +1 more source

Proteomics Insights Into Lysosome Biogenesis and Maturation

PROTEOMICS, Volume 25, Issue 21-22, Page 6-24, November 2025.
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Katharina Hirn, Sofía Fajardo‐Callejón, Dominic Winter   +2 more
wiley   +1 more source

Identification of potential biomarkers and candidate small molecule drugs in glioblastoma

Cancer Cell International, 2020
Background and aims Glioblastoma (GBM) is a common and aggressive primary brain tumor, and the prognosis for GBM patients remains poor. This study aimed to identify the key genes associated with the development of GBM and provide new diagnostic and ...
Wei-cheng Lu, Hui Xie, Ce Yuan, Jin-jiang Li, Zhao-yang Li, An-hua Wu   +5 more
doaj   +1 more source

Prognostic significance of AP-2α/γ targets as cancer therapeutics

Scientific Reports, 2022
Identifying genes with prognostic importance could improve cancer treatment. An increasing number of reports suggest the existence of successful strategies based on seemingly “untargetable” transcription factors.
Damian Kołat, Żaneta Kałuzińska, Andrzej K. Bednarek, Elżbieta Płuciennik   +3 more
doaj   +1 more source