Results 51 to 60 of about 1,113 (145)

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

The unfolded protein response and its potential role in Huntington ́s disease elucidated by a systems biology approach [v1; ref status: indexed, http://f1000r.es/59e]

F1000Research, 2015
Huntington ́s disease (HD) is a progressive, neurodegenerative disease with a fatal outcome. Although the disease-causing gene (huntingtin) has been known for over 20 years, the exact mechanisms leading to neuronal cell death are still controversial. One
Ravi Kiran Reddy Kalathur, Joaquin Giner-Lamia, Susana Machado, Kameshwar R S Ayasolla, Matthias E. Futschik   +4 more
doaj   +1 more source

Screening of possible biomarkers and therapeutic targets in kidney renal clear cell carcinoma: Evidence from bioinformatic analysis

Frontiers in Oncology, 2022
Renal cell carcinoma (RCC), as one of the most common urological malignancies, has many histologic and molecular subtypes, among which clear cell renal cell carcinoma (ccRCC) is one of the most common causes of tumor-related deaths.
Longfei Peng, Zhangjun Cao, Qi Wang, Lu Fang, Songbai Yan, Dian Xia, Jinyou Wang, Liangkuan Bi   +7 more
doaj   +1 more source

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival [PDF]

, 2011
Background Glioblastoma Multiforme (GBM) is the most common and invasive astrocytic tumor associated with dismal prognosis. Treatment for GBM patients has advanced, but the median survival remains a meager 15 months.
Avadhut D Joshi, D Parsons, Victor E Velculescu, Gregory J Riggins   +3 more
core   +2 more sources

Integrated Analysis of the LncRNA‐Mediated ceRNA Network Associated With Prognosis in Posttreatment Recurrent Nasopharyngeal Carcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT The competing endogenous RNA hypothesis offers new insights into tumour progression, yet its role in posttreatment nasopharyngeal carcinoma relapse remains unclear. This study constructed ceRNA networks to identify molecular markers associated with NPC relapse.
Qihong Liu, Jingxiao Lu, Zhiqiang Wang, Qingming Li, Jianhui Wu, Kexing Lyu, Beiping Miao, Wenbin Lei, Guohui Nie, Xiaoqin Fan   +9 more
wiley   +1 more source

Comparative sequence analysis reveals an intricate network among , and miRNA in mediating neuronal gene expression [PDF]

, 2006
Using comparative sequence analysis, a network among REST, CREB and brain-related miRNAs is propsed to mediate neuronal gene expression. BACKGROUND.
Wu, Jie, Xie, Xiaohui
core   +2 more sources

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer [PDF]

, 2020
Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases (MMP) genes (rs1799750 MMP1, rs3918242 and rs17576 MMP9 ) in Russian patients with primary open ...
Buraczynska, Chehaibi, Chen, Devulapalli, Goncharov, Hao, He, He, Huang, Huang, Kim, Krishnaveni, Lacchini, Li, Luizon, Majsterek, Markiewicz, Micheal, Miller, Misra, Moskalenko, Moskalenko, Moskalenko, Moskalenko, Mossböck, Okada, Peng, Polonikov, Ponomarenko, Ponomarenko, Ritter, Shaymardanova, Sorokina, Svinareva, Tanner, Thakur, Wang, Wen, Wu, Wu, Yang, Yi, Yi, Yi, Zhang, Zhang, Zhang, Zhao, Zhao   +48 more
core   +1 more source

Proteomics Insights Into Lysosome Biogenesis and Maturation

PROTEOMICS, Volume 25, Issue 21-22, Page 6-24, November 2025.
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Katharina Hirn, Sofía Fajardo‐Callejón, Dominic Winter   +2 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, Volume 19, Issue 8, Page 2270-2291, August 2025.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Identification of a prognostic signature based on ammonia metabolism-related genes in clear cell renal cell carcinoma: an integrated analysis of bulk and single-cell transcriptomics

Frontiers in Immunology
BackgroundClear cell renal cell carcinoma (ccRCC) is an angiogenic tumor originating from proximal tubule epithelial cells. Ammonia induced cell death is closely associated with carcinogenesis, but its potential mechanism in ccRCC remains unclear and ...
Yao Jiang, Tian Zhang, Jie Fan, Yansheng Su, Shaoyi Qiao, Jintao Ji, Xiangnan Hu, Shuchang Zhou, Yingjuan Wei, Lina Du, Bo Yang, Wuhe Zhang   +11 more
doaj   +1 more source