Results 51 to 60 of about 82 (65)
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Archives of Medical Research, 2022
Cervical cancer (CC) is a common female malignant tumor. With the trend of younger onset, people pay more and more attention to it. Numberless evidence has been indicated that long non-coding RNAs (lncRNAs) can take part in progression of cancers and can exert the regulatory roles in assorted cancers. Nevertheless, the roles of FEZ family zinc finger 1-
Xiaowei, Yang, Yuejie, Qu, Jixian, Zhang
exaly +3 more sources
Cervical cancer (CC) is a common female malignant tumor. With the trend of younger onset, people pay more and more attention to it. Numberless evidence has been indicated that long non-coding RNAs (lncRNAs) can take part in progression of cancers and can exert the regulatory roles in assorted cancers. Nevertheless, the roles of FEZ family zinc finger 1-
Xiaowei, Yang, Yuejie, Qu, Jixian, Zhang
exaly +3 more sources
Frontiers in Molecular NeuroscienceThe potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development. In mature neurons, KCC2 maintains a low enough intracellular chloride concentration essential for inhibitory neurotransmission.
Jonna Komulainen-Ebrahim +2 more
exaly +4 more sources
Naunyn-Schmiedeberg's Archives of Pharmacology
Glioblastoma multiforme (GBM), an aggressive brain tumor with a dismal prognosis, lacks robust prognostic biomarkers. In this study, we aimed to identify novel biomarkers using integrative bioinformatics, radiomics, and experimental validation. Using the GEO, TCGA, and CGGA datasets, we screened 387 differentially expressed genes (DEGs) and identified ...
Zengwei Kou +2 more
exaly +3 more sources
Glioblastoma multiforme (GBM), an aggressive brain tumor with a dismal prognosis, lacks robust prognostic biomarkers. In this study, we aimed to identify novel biomarkers using integrative bioinformatics, radiomics, and experimental validation. Using the GEO, TCGA, and CGGA datasets, we screened 387 differentially expressed genes (DEGs) and identified ...
Zengwei Kou +2 more
exaly +3 more sources
BiomedicinesValproic acid (VPA) has anticancer, anti-inflammatory, and epigenetic effects. The study aimed to determine the expression of carcinogenesis-related SLC5A8, SLC12A2, SLC12A5, CDH1, and CDH2 in adult glioblastoma U87 MG and T98G cells and the effects of 0.5 mM, 0.75 mM, and 1.5 mM doses of VPA. RNA gene expression was determined by RT-PCR.
Ingrīda Balnytė +2 more
exaly +5 more sources
Novel Homozygous Full Gene Deletion of
ABSTRACT SLC12A5 codes for a protein that mediates electroneutral potassium–chloride cotransport in mature neurons and is required to maintain chloride homeostasis in neurons. Pathogenic missense or truncating variants in SLC12A5 are associated with ...
Lauren M. Wainman +5 more
openaire +2 more sources
Molecular Medicine ReportsSolute carrier family 12 member 5 (SLC12A5) is an oncogene in numerous types of cancer, however its function in breast cancer (BC) remains elusive. ETS translocation variant 4 (ETV4) promotes BC. Therefore, the present study aimed to elucidate the role of SLC12A5 in ferroptosis and glucose metabolism in BC cells as well as to understand the underlying ...
Wang, Huan, Dai, Yanyan, Wang, Fengxiang
exaly +3 more sources
Clinical Genetics, 2017
Epilepsy of infancy with migrating focal seizures (EIMFS) is an infantile epileptic encephalopathy characterized by refractory seizures, severe psychomotor delay, and multiple moving epileptic discharges. The genetic etiology of EIMFS is relatively homogeneous with the majority of causative mutations found in KCNT1. Currently, gene panel or whole‐exome
T. Saito +4 more
openaire +2 more sources
Epilepsy of infancy with migrating focal seizures (EIMFS) is an infantile epileptic encephalopathy characterized by refractory seizures, severe psychomotor delay, and multiple moving epileptic discharges. The genetic etiology of EIMFS is relatively homogeneous with the majority of causative mutations found in KCNT1. Currently, gene panel or whole‐exome
T. Saito +4 more
openaire +2 more sources
Cytogenetic and Genome Research, 2001
K<sup>+</sup>-Cl<sup>–</sup> cotransporters (KCCs) constitute a branch of the cation-chloride cotransporter (CCC) family. To date, four KCC isoforms (KCC1-KCC4) have been identified and they all mediate obligatorily coupled, electroneutral transmembrane movement of K<sup>+</sup> and Cl<sup>–</sup> ions ...
R. Sallinen +5 more
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K<sup>+</sup>-Cl<sup>–</sup> cotransporters (KCCs) constitute a branch of the cation-chloride cotransporter (CCC) family. To date, four KCC isoforms (KCC1-KCC4) have been identified and they all mediate obligatorily coupled, electroneutral transmembrane movement of K<sup>+</sup> and Cl<sup>–</sup> ions ...
R. Sallinen +5 more
openaire +1 more source
Expression, Characterization, Cloning and Functional Impact of Slc12a5 in the Endocrine Pancreas
2014The Slc12a5 gene encodes the neuron-specific electroneutral K+Cl- cotransporter-2 (KCC2), a constitutively active Cl- extruder. In mature neurons, KCC2 functionally predominates over other members of the Slc12a family, particularly the Na+K+2Cl- cotransporter-1 (NKCC1), a ubiquitous Cl- loader.
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679 Identification and Characterization of a Novel Amplification Gene Slc12a5 in Colorectal Cancer
Gastroenterology, 2013Lixia Xu +6 more
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