Results 31 to 40 of about 82 (65)

Additional file 3 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 3.Figure S3 (a) Flow cytometry analysis of the effect of IHMT-337 on apoptosis in U87 and U251 cells. (b) TUNEL assay to evaluate the effect of IHMT-337 on apoptosis in U87 and U251 cells. (c) EdU assay assessing the impact of IHMT-337 on cell proliferation in U251 cells.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2 ‐developmental and epileptic encephalopathy

Epilepsia
Abstract Objective This study was undertaken to characterize the functional impact of novel SLC12A5 variants in two unrelated patients with early onset developmental and epileptic encephalopathy (DEE) and to investigate the ...
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
openaire   +1 more source

Additional file 4 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 4.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Additional file 2 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 2. Figure S2 (a) Methylation status of CpG islands in the SLC12A5 gene, with the red box indicating the CpG island selected for experimental purposes. (b) Effects of KCC2 overexpression and knockdown on WNK1 activity in U251 cells.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Additional file 1 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 1.Figure S1 (a) Analysis of EZH2's impact on prognosis in recurrent gliomas using the CGGA database. (b) Evaluation of EZH2's prognostic influence using the TCGA database. (c) Expression levels of SLC12A5 in different types of gliomas. (d) Influence of SLC12A5 on the prognosis of primary gliomas in the CGGA database.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Mendelian randomisation and colocalisation reveal pleiotropic effects of CD40/SLC12A5 locus on CD40 protein, depression, and immune disease

Abstract Inflammatory pathways are implicated in depression, but the specific immune proteins and causal variants involved remain unclear. This study investigated potential causal relationships between 91 immune-related plasma proteins and depression using generalized summary Mendelian randomisation.
Rachel Laattoe, Elina Hypponen, David Stacey, Sarah Cohen-Woods   +3 more
openaire   +1 more source

Solute carrier family 12 potassium-chloride transporter member 5 (SLC12A5; KCC2) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes

Cancer Medicine, 2023
AbstractBackgroundHepatocellular carcinoma (HCC) has a poor prognosis and new effective treatments are needed. SLC12A5 plays important roles in multiple complex pathological states and is overexpressed in a variety of malignancies. However, the effects of SLC12A5 in HCC have not been determined.MethodsSLC12A5 expression was assessed by immunostaining ...
Qing Tong
exaly   +4 more sources

Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing [PDF]

Cell Research, 2014
Single-cell sequencing is a powerful tool for delineating clonal relationship and identifying key driver genes for personalized cancer management. Here we performed single-cell sequencing analysis of a case of colon cancer. Population genetics analyses identified two independent clones in tumor cell population.
Chang Yu, Jun Yu, Xiaotian Yao
exaly   +6 more sources

SLC12A5 interacts and enhances SOX18 activity to promote bladder urothelial carcinoma progression via upregulating MMP7 [PDF]

Cancer Science, 2020
AbstractSolute carrier family 12 member 5 (SLC12A5) has an oncogenic role in bladder urothelial carcinoma. The present study aimed to characterize the molecular mechanisms of SLC12A5 in bladder urothelial carcinoma pathogenesis. Functional assays identified that in bladder urothelial carcinoma SLC12A5 interacts with and stabilizes SOX18, and then ...
Qun Zhang, Dan Xie, Minhua Deng
exaly   +3 more sources