Results 31 to 40 of about 1,526 (158)
Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K+-Cl- Cotransporter KCC2 [PDF]
, 2019 Chloride (Cl-) homeostasis is an essential process involved in neuronal signalling and cell survival. Inadequate regulation of intracellular Cl- interferes with synaptic signalling and is implicated in several neurological diseases.
J Zhang (7490018), L Tillman (21680075)
core +8 more sources
FEBS Open Bio, 2021 Glioblastoma multiforme (GBM) is the most malignant primary tumour in the central nervous system, but the molecular mechanisms underlying its pathogenesis remain unclear.
Chun Li +6 more
doaj +1 more source
Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction
Brain Research, 2019 SLC12A5 encodes K+-Cl- cotransporter 2 (KCC2), which is the main Cl- extruder of neurons, and renders the proper inhibitory function of the neurotransmitters γ-aminobutyric acid (GABA) and glycine. Thus, any variant in SLC12A5, if it causes dysfunction of KCC2, could be pathogenic for neurological and psychiatric disorders by disrupting inhibition and ...
Atsuo Fukuda, Miho Watanabe
openaire +2 more sources
ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells. [PDF]
Mol Med RepSolute carrier family 12 member 5 (SLC12A5) is an oncogene in numerous types of cancer, however its function in breast cancer (BC) remains elusive. ETS translocation variant 4 (ETV4) promotes BC. Therefore, the present study aimed to elucidate the role of SLC12A5 in ferroptosis and glucose metabolism in BC cells as well as to understand the underlying ...
Wang H, Dai Y, Wang F.
europepmc +3 more sources
Frontiers in Oncology, 2022 Glioblastoma multiforme (GBM) is the most frequent malignant type of primary brain cancers and is a malignancy with poor prognosis. Thus, it is necessary to find novel therapeutic modalities based on molecular events occur at different stages of tumor ...
Soudeh Ghafouri-Fard +7 more
doaj +1 more source
Transcriptome Analyses Provide Insights into the Auditory Function in Trachemys scripta elegans
Animals, 2022 An auditory ability is essential for communication in vertebrates, and considerable attention has been paid to auditory sensitivity in mammals, birds, and frogs.
Ningning Lu +6 more
doaj +1 more source
Siliao yanjiu, 2022 The experiment was to study the effect of dietary methionine levels on expression of SLC12A5 and Musclin mRNA in thigh and breast muscles of Dagu chickens.
Ke-xin LIU +7 more
doaj
The Expanding Therapeutic Potential of Neuronal KCC2
Cells, 2020 Dysfunctions in GABAergic inhibitory neural transmission occur in neuronal injuries and neurological disorders. The potassium−chloride cotransporter 2 (KCC2, SLC12A5) is a key modulator of inhibitory GABAergic inputs in healthy adult neurons, as ...
Bor Luen Tang
doaj +1 more source
Erratum: Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library [PDF]
Frontiers in Molecular NeuroscienceFrontiers Production Office
doaj +2 more sources
Neurobiology of Disease, 2018 Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in various organs and arises due to mutations in the TSC1 or TSC2 genes. TSC mutations lead to a range of neurological manifestations including epilepsy, cognitive impairment ...
Shruti Bagla +7 more
doaj +1 more source