Results 21 to 30 of about 82 (65)

Novel Genes Associated With Working Memory Are Identified by Combining Connectome, Transcriptome, and Genome

Human Brain Mapping, Volume 46, Issue 1, January 2025.
We discovered 24 novel genes linked to working memory by integrating brain imaging, gene expression, and genetic data, validated in ABCD and UK Biobank. This highlights key pathways, offering new insights into the genetic basis of cognition. ABSTRACT Working memory (WM) plays a crucial role in human cognition.
Xiaoyu Zhao, Ruochen Yin, Chuansheng Chen, Sebastian Markett, Xinrui Wang, Gui Xue, Qi Dong, Chunhui Chen   +7 more
wiley   +1 more source

Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex

Advanced Science, Volume 11, Issue 47, December 18, 2024.
This study applies spatial transcriptomics and single‐cell RNA sequencing to study molecular heterogeneity of subplate neurons (SPNs) in human fetal brains from gestational week 10 to 25. Human‐specific and extracellular matrices (ECM) genes are found to maintain SPN population. Enriched ECM gene expressions in the frontal lobe suggest a potential role
Xueyu Guo, Trevor Lee, Jason Sun, Julianne Sun, Wenjie Cai, Qingwei Yang, Tao Sun   +6 more
wiley   +1 more source

ABC Efflux Transporters and Solute Carriers in the Early Developing Brain of a Marsupial Monodelphis domestica (South American Gray Short‐Tailed Opossum)

Journal of Comparative Neurology, Volume 532, Issue 7, July 2024.
We compared transcriptomic profiles and functionality of ABC and SLC transporters in marsupial Monodelphis domestica brain and eutherian rat brain and placenta. Data indicate that despite its extreme immaturity, Monodelphis brain may compensate for a lack of placental protection during early brain development by upregulating protective mechanisms ...
Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Fiona Qiu, Ana C. C. Leandro, Paul D. Callaghan, Joanne E. Curran, John L. VandeBerg, Norman R. Saunders   +8 more
wiley   +1 more source

Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5

Journal of Cellular and Molecular Medicine
AbstractHepatocellular carcinoma (HCC) presents a persistent challenge to conventional therapeutic approaches. SLC12A5 is implicated in an oncogenic capacity and facilitates the progression of cancer. The objective of this investigation is to scrutinize the inhibitory effects of borax on endoplasmic reticulum (ER)‐stress and apoptosis mediated by ...
Ceyhan Hacioglu, Didem Oral
openaire   +3 more sources

Comprehensive analysis of lncRNA‐associated ceRNA network reveals novel potential prognostic regulatory axes in glioblastoma multiforme

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Deciphering the lncRNA‐associated competitive endogenous RNA (ceRNA) network is essential in decoding glioblastoma multiforme (GBM) pathogenesis by regulating miRNA availability and controlling mRNA stability. This study aimed to explore novel biomarkers for GBM by constructing a lncRNA‐miRNA‐mRNA network.
Maryam Bazrgar, Seyed Amir Mirmotalebisohi, Mohsen Ahmadi, Parisa Azimi, Leila Dargahi, Hakimeh Zali, Abolhassan Ahmadiani   +6 more
wiley   +1 more source

The olfactory bulb: A neuroendocrine spotlight on feeding and metabolism

Journal of Neuroendocrinology, Volume 36, Issue 6, June 2024.
Abstract Olfaction is the most ancient sense and is needed for food‐seeking, danger protection, mating and survival. It is often the first sensory modality to perceive changes in the external environment, before sight, taste or sound. Odour molecules activate olfactory sensory neurons that reside on the olfactory epithelium in the nasal cavity, which ...
Romana Stark
wiley   +1 more source

Epilepsy of Infancy With Migrating Focal Seizures

Annals of the Child Neurology Society, Volume 3, Issue 2, Page 125-126, June 2025.
Samuel Kamoroff, Harry Abram, Fernando Galan   +2 more
wiley   +1 more source

Comparison of the Effect of the Combination of Sodium Valproate and Sodium Dichloroacetate on the Expression of SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP in Primary Female Glioblastoma Cells with That of Temozolomide

Pharmaceutics
The search for an effective treatment for adult high-grade glioblastoma (GBM) remains urgent. Background/Objectives: The study aimed to determine the expression of carcinogenesis-related genes, such as SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP, in primary glioblastoma (WHO Grade IV; IDH-wild-type) cells from three adult women: GBM5-1, GBM5-2F, and ...
Dovydas Gečys, Laimis Akramas, Aidanas Preikšaitis, Ingrida Balnytė, Arūnas Vaitkevičius, Julija Šimienė, Donatas Stakišaitis   +6 more
openaire   +3 more sources

Additional file 5 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 5.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Additional file 6 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 6.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source