Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis [PDF]
, 2007 Background Amyotrophic lateral sclerosis (ALS) is a fatal disorder caused by the progressive degeneration of motoneurons in brain and spinal cord. Despite identification of disease-linked mutations, the diversity of processes involved and the ambiguity ...
Santama Niovi +4 more
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Frontiers in Oncology, 2022 Glioblastoma multiforme (GBM) is the most frequent malignant type of primary brain cancers and is a malignancy with poor prognosis. Thus, it is necessary to find novel therapeutic modalities based on molecular events occur at different stages of tumor ...
Soudeh Ghafouri-Fard +7 more
doaj +1 more source
Transcriptome Analyses Provide Insights into the Auditory Function in Trachemys scripta elegans
Animals, 2022 An auditory ability is essential for communication in vertebrates, and considerable attention has been paid to auditory sensitivity in mammals, birds, and frogs.
Ningning Lu +6 more
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A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells [PDF]
, 2017 Background: Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K-Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression in mammals.
Ludwig, Anastasia +2 more
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Sequence Variation Associated with SLC12A5 Gene Expression Is Linked to Brain Structure and Function in Healthy Adults [PDF]
Cerebral Cortex, 2019 Abstract A single-nucleotide polymorphism in the promoter region of the Matrix Metalloproteinase-9 (MMP9) gene, rs3918242, has been shown to affect MMP9 expression in macrophages and was associated with schizophrenia by two independent groups.
Michael D Gregory +6 more
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Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain [PDF]
, 2015 Peer ...
Jovanov-Milošević, Natasa +6 more
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The Expanding Therapeutic Potential of Neuronal KCC2
Cells, 2020 Dysfunctions in GABAergic inhibitory neural transmission occur in neuronal injuries and neurological disorders. The potassium−chloride cotransporter 2 (KCC2, SLC12A5) is a key modulator of inhibitory GABAergic inputs in healthy adult neurons, as ...
Bor Luen Tang
doaj +1 more source
Dexamethasone in glioblastoma multiforme therapy : mechanisms and controversies [PDF]
, 2019 Glioblastoma multiforme (GBM) is the most common and malignant of the glial tumors. The world-wide estimates of new cases and deaths annually are remarkable, making GBM a crucial public health issue.
Luigi Sforna +8 more
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Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures [PDF]
, 2014 Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults.
Delpire E +7 more
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Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation [PDF]
, 2019 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Troetschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Boenigk, W., Koerschen, H.
Alvarez, Luis +14 more
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