Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment [PDF]
ChannelsNeuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter.
Morgan Kok +3 more
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Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain [PDF]
Acta Neuropathologica CommunicationsTraumatic brain injury (TBI) is a leading cause of morbidity and mortality in infants and toddlers, with limited treatment options and persistent neurological sequelae.
Alexandra Hochstetler +11 more
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Experimental NeurologyInternational audienceThe potassium-chloride cotransporter 2 (KCC2) is a neuron-specific transporter essential for maintaining low intracellular chloride levels.
Balogh, Istvan +11 more
core +3 more sources
Single-cell transcriptome analysis identifies a novel tumor-associated macrophage subtype predicting better prognosis in pancreatic ductal adenocarcinoma [PDF]
Frontiers in Cell and Developmental BiologyBackgroundCharacterized by an immune-suppressive tumor microenvironment (TME), pancreatic ductal adenocarcinoma (PDAC) is well-known for its poor prognosis. Tumor associated macrophages (TAMs) play a critical role in PDAC TME.
Xiaonan Wang +6 more
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Development of KCC2 therapeutics to treat neurological disorders [PDF]
Frontiers in Molecular NeuroscienceKCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS.
Shilpa D. Kadam, Shane V. Hegarty
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Allele specific expression in Alzheimer's disease. [PDF]
Alzheimers DementAbstract INTRODUCTION Allele‐specific expression (ASE), preferential expression of one allele at a heterozygous locus, is implicated in various brain diseases but remains largely uncharacterized in Alzheimer's disease (AD). METHODS We performed a genome‐wide characterization of ASE variants across seven brain regions of 2,231 AD and Control patients ...
Wang Z +6 more
europepmc +2 more sources
A Pan-Cancer Analysis of SLC12A5 Reveals Its Correlations with Tumor Immunity [PDF]
Disease Markers, 2021 Background. Solute carrier family 12 member 5 (SLC12A5) has been reported to play an oncogenic role in certain malignancies. Its prognostic roles and immune mechanisms of action in human cancers, however, remain largely unknown. Methods. Data derived from TCGA, GEPIA, and TIMER databases were utilized to delve into the expressing patterns, prognostic ...
Yi Jiang, Hong-li Liao, Li-ya Chen
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Cell Death and Disease, 2023 SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported to promote tumor progression, however, the underlying mechanism remains unclear.
Shuai Yuan +13 more
doaj +1 more source
When Are Depolarizing GABAergic Responses Excitatory?
Frontiers in Molecular Neuroscience, 2021 The membrane responses upon activation of GABA(A) receptors critically depend on the intracellular Cl− concentration ([Cl−]i), which is maintained by a set of transmembrane transporters for Cl−.
Werner Kilb
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Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K+-Cl– cotransporter (KCC2) defines a new region of conserved homology [PDF]
Cytogenetic and Genome Research, 2003 K(+)-Cl(-) cotransporters (KCCs) constitute a branch of the cation-chloride cotransporter (CCC) family. To date, four KCC isoforms (KCC1-KCC4) have been identified and they all mediate obligatorily coupled, electroneutral transmembrane movement of K(+) and Cl(-) ions.
R, Sallinen +5 more
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