Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia [PDF]
Frontiers in Cellular Neuroscience, 2015 Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D Merner +7 more
doaj +8 more sources
Epigenetic Clock in Bears: A Simple Cost‐Effective Blood DNA Methylation‐Based Age Estimation Method Applicable to Multiple Bear Species [PDF]
Ecology and EvolutionAge is an essential factor to understand the life history and demographic parameters of wildlife. Previously, we established an age estimation method for brown bears based on blood DNA methylation level.
Michito Shimozuru +17 more
doaj +3 more sources
Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing [PDF]
Cell Research, 2014 Single-cell sequencing is a powerful tool for delineating clonal relationship and identifying key driver genes for personalized cancer management. Here we performed single-cell sequencing analysis of a case of colon cancer.
Jun Yu, Senwei Tang, Qiaoyi Liang
exaly +7 more sources
Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis [PDF]
Molecular MedicineGlioma is the most common malignant tumor of the central nervous system, with EZH2 playing a crucial regulatory role. This study further explores the abnormal expression of EZH2 and its mechanisms in regulating glioma progression.
Hongwei Zhang +6 more
doaj +4 more sources
Family History of Hypertension Predicts Thyroid Cancer Risk in Women: A Population‐Based Cross‐Sectional Study With Integrative Machine Learning and Genomic Analyses [PDF]
Cancer MedicineIntroduction Thyroid cancer is one of the most common endocrine malignancies globally, with a markedly higher incidence in women. Although pregnancy‐induced hypertension is recognized as a risk factor, the underlying mechanisms linking hypertension and ...
Zijin Wang +9 more
doaj +3 more sources
Epilepsy of Infancy With Migrating Focal Seizures [PDF]
Annals of the Child Neurology SocietyAnnals of the Child Neurology Society, Volume 3, Issue 2, Page 125-126, June 2025.
Samuel Kamoroff +2 more
doaj +3 more sources
SLC12A5 antibody characterization report
, 2023 <p>This report guides researchers to select the most appropriate antibodies for Solute Carrier Family 12 Member 5. We used an antibody characterization pipeline based on knockout overexpression (KOOE) and knockout (KO) cells to perform head-to-head
Gelova, Zuzana, Garcia, Julio
core +2 more sources
Identification of a prognostic signature based on ammonia metabolism-related genes in clear cell renal cell carcinoma: an integrated analysis of bulk and single-cell transcriptomics [PDF]
Frontiers in ImmunologyBackgroundClear cell renal cell carcinoma (ccRCC) is an angiogenic tumor originating from proximal tubule epithelial cells. Ammonia induced cell death is closely associated with carcinogenesis, but its potential mechanism in ccRCC remains unclear and ...
Yao Jiang +11 more
doaj +2 more sources
Purification of SLC12A5 from Expi293FTM Cells
, 2022 <p>This protocol is used to purify the SLC transporter expressed in Expi293FTM Cells using detergent solubilization followed by a series of different chromatographic methods.
Tina Bohstedt +5 more
core +3 more sources
Expression, Characterization, Cloning and Functional Impact of Slc12a5 in the Endocrine Pancreas [PDF]
, 2014 The Slc12a5 gene encodes the neuron-specific electroneutral K+Cl- cotransporter-2 (KCC2), a constitutively active Cl- extruder. In mature neurons, KCC2 functionally predominates over other members of the Slc12a family, particularly the Na+K+2Cl ...
Kursan, Shams
core +4 more sources