Results 11 to 20 of about 82 (65)

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Integrated Analysis of the LncRNA‐Mediated ceRNA Network Associated With Prognosis in Posttreatment Recurrent Nasopharyngeal Carcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT The competing endogenous RNA hypothesis offers new insights into tumour progression, yet its role in posttreatment nasopharyngeal carcinoma relapse remains unclear. This study constructed ceRNA networks to identify molecular markers associated with NPC relapse.
Qihong Liu, Jingxiao Lu, Zhiqiang Wang, Qingming Li, Jianhui Wu, Kexing Lyu, Beiping Miao, Wenbin Lei, Guohui Nie, Xiaoqin Fan   +9 more
wiley   +1 more source

Proteomics Insights Into Lysosome Biogenesis and Maturation

PROTEOMICS, Volume 25, Issue 21-22, Page 6-24, November 2025.
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Katharina Hirn, Sofía Fajardo‐Callejón, Dominic Winter   +2 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, Volume 19, Issue 8, Page 2270-2291, August 2025.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Family History of Hypertension Predicts Thyroid Cancer Risk in Women: A Population‐Based Cross‐Sectional Study With Integrative Machine Learning and Genomic Analyses

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Introduction Thyroid cancer is one of the most common endocrine malignancies globally, with a markedly higher incidence in women. Although pregnancy‐induced hypertension is recognized as a risk factor, the underlying mechanisms linking hypertension and thyroid cancer remain poorly understood.
Zijin Wang, Yanhui Lin, Fanke Meng, Yuxin Sun, Ziran Zhang, Tong Wu, Min Fu, Fanye Wu, Zhengran Li, Zejun Chen   +9 more
wiley   +1 more source

Clinical whole genome sequencing in pediatric epilepsy: Genetic and phenotypic spectrum of 733 individuals

Epilepsia, Volume 66, Issue 8, Page 2966-2979, August 2025.
Abstract Objective A large proportion of pediatric epilepsies have an underlying genetic etiology. Limited studies have explored the efficacy of whole genome sequencing (WGS) in a clinical setting. Our academic–clinical center implemented clinical whole exome sequencing (WES) in 2014, then transitioned to WGS from 2015.
Olivia J. Henry, Sofia Ygberg, Michela Barbaro, Nicole Lesko, Leif Karlsson, Lucía Peña‐Pérez, Ann Båvner, Virpi Töhönen, Anna Lindstrand, Tommy Stödberg, Anna Wedell   +10 more
wiley   +1 more source

Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Molecular Medicine
AbstractGlioma is the most common malignant tumor of the central nervous system, with EZH2 playing a crucial regulatory role. This study further explores the abnormal expression of EZH2 and its mechanisms in regulating glioma progression. Additionally, it was found that IHMT-337 can potentially be a therapeutic agent for glioma.
Hongwei Zhang, Zixuan Wang, Xiaolong Qiao, Nan Peng, Jiaxing Wu, Yinan Chen, Chuandong Cheng   +6 more
openaire   +3 more sources

Epigenetic Clock in Bears: A Simple Cost‐Effective Blood DNA Methylation‐Based Age Estimation Method Applicable to Multiple Bear Species

Ecology and Evolution, Volume 15, Issue 5, May 2025.
Age is an essential factor to understand the life history and demographic parameters of wildlife. In this study, we built a common epigenetic clock model for multiple bear species, including brown, Asian black, polar, sun, and Andean bears. The model will contribute to ecological research, conservation, and management of bear species.
Michito Shimozuru, Shiori Nakamura, Jumpei Yamazaki, Yojiro Yanagawa, Hiroo Tamatani, Misako Kuroe, Koji Yamazaki, Shinsuke Koike, Yusuke Goto, Tomoko Naganuma, Kahoko Tochigi, Akino Inagaki, Naoki Takekoshi, Seungyun Baek, Nobutaka Sato, Yusuke Honda, Toshio Tsubota, Hideyuki Ito   +17 more
wiley   +1 more source

Brain phosphoproteomic analysis identifies diabetes‐related substrates in Alzheimer's disease pathology in older adults

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Type 2 diabetes increases the risk of Alzheimer's disease (AD) dementia. Insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of AD pathology. However, the comprehensive impact of diabetes on patterns of AD‐related phosphoprotein in the human brain remains underexplored.
Ana W. Capuano, Vishal Sarsani, Shinya Tasaki, Rupal I. Mehta, Jun Li, Rexford Ahima, Steven Arnold, David A. Bennett, Vladislav Petyuk, Liming Liang, Zoe Arvanitakis   +10 more
wiley   +1 more source

Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities

Advanced Science, Volume 12, Issue 4, January 27, 2025.
Tumors develop resistance to therapeutic agents, unfortunately, efforts to overcome resistance have achieved limited success. m6A RNA modification dysregulation is an emerging mechanism for cancer therapy resistance. This review comprehensively discusses recent studies regarding the contributions of m6A modification and its regulators to cancer therapy
Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang   +2 more
wiley   +1 more source