Results 61 to 70 of about 1,526 (158)
, 2017 Solute carrier family 12 member 5 (SLC12A5), an integral membrane KCl cotransporter, which maintains chloride homeostasis in neurons, is aberrantly expressed and involved in the tumorigenesis of certain cancers.
Y L Ye +17 more
core +1 more source
Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1 [PDF]
, 2008 Human chromosome 20q12-q13.1 has been linked to type 2 diabetes mellitus (T2DM) in multiple studies. We screened a 5.795-Mb region for diabetes-related susceptibility genes in a Caucasian cohort of 310 controls and 300 cases with T2DM and end-stage renal
Langefeld, C.D. +11 more
core +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, Volume 19, Issue 8, Page 2270-2291, August 2025.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Epilepsia, Volume 66, Issue 8, Page 2966-2979, August 2025.Abstract Objective A large proportion of pediatric epilepsies have an underlying genetic etiology. Limited studies have explored the efficacy of whole genome sequencing (WGS) in a clinical setting. Our academic–clinical center implemented clinical whole exome sequencing (WES) in 2014, then transitioned to WGS from 2015.
Olivia J. Henry +10 more
wiley +1 more source
, 2022 In this study, pyruvate dehydrogenase kinase-1 inhibition with dichloroacetate (DCA) was explored as an alternative cancer therapy. The study’s aim was to compare the effectiveness of NaDCA and MgDCA on pediatric glioblastoma PBT24 and SF8628 ...
Marta Marija Alonso +11 more
core +1 more source
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.Abstract INTRODUCTION Type 2 diabetes increases the risk of Alzheimer's disease (AD) dementia. Insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of AD pathology. However, the comprehensive impact of diabetes on patterns of AD‐related phosphoprotein in the human brain remains underexplored.
Ana W. Capuano +10 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2011 Mutations in the homeobox transcription factor ARX have been found to be responsible for a wide spectrum of disorders extending from phenotypes with severe neuronal migration defects, such as lissencephaly, to mild forms of intellectual disabilities ...
Gaelle M Friocourt, John G Parnavelas
doaj +1 more source
Advanced Science, Volume 12, Issue 4, January 27, 2025.Tumors develop resistance to therapeutic agents, unfortunately, efforts to overcome resistance have achieved limited success. m6A RNA modification dysregulation is an emerging mechanism for cancer therapy resistance. This review comprehensively discusses recent studies regarding the contributions of m6A modification and its regulators to cancer therapy
Mohammad Burhan Uddin +2 more
wiley +1 more source
Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
Cells, 2019 The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer’s disease (AD), are generated by sequential proteolytic processing involving β- and γ-secretases.
Bor Luen Tang
doaj +1 more source
Human Brain Mapping, Volume 46, Issue 1, January 2025.We discovered 24 novel genes linked to working memory by integrating brain imaging, gene expression, and genetic data, validated in ABCD and UK Biobank. This highlights key pathways, offering new insights into the genetic basis of cognition. ABSTRACT Working memory (WM) plays a crucial role in human cognition.
Xiaoyu Zhao +7 more
wiley +1 more source