Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders
, 2018 The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Hines, Rochelle M. +2 more
core +2 more sources
Global Properties of M31's Stellar Halo from the SPLASH Survey: III. Measuring the Stellar Velocity Dispersion Profile [PDF]
, 2017 We present the velocity dispersion of red giant branch (RGB) stars in M31's halo, derived by modeling the line of sight velocity distribution of over 5000 stars in 50 fields spread throughout M31's stellar halo.
Beaton, Rachael L. +9 more
core +3 more sources
BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia
Translational Neuroscience, 2015 Abstract Purpose: To investigate the effect of brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase (Trk) on potassium chloride cotransporter 2 (KCC2) in rats following nicotine withdrawal and the roles played by BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia.
Shi Wenhui +5 more
openaire +3 more sources
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments [PDF]
, 2016 Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience.
Badura, A.M. (Aleksandra) +3 more
core +6 more sources
Neurobiology of Disease, 2020 Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV.
Aaron J. Barbour +3 more
doaj +1 more source
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination [PDF]
, 2016 Synaptic inhibition in the olfactory bulb (OB), the first relay station of olfactory information, is believed to be important for odour discrimination.
Carleton, Alan +5 more
core +3 more sources
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]
Epilepsy Research, 2008 During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu +3 more
openaire +2 more sources
Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation
Frontiers in Molecular Neuroscience, 2023 The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature ...
Domenico Del Turco +8 more
doaj +1 more source
The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley +1 more source
Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission [PDF]
The Journal of Neuroscience, 2006 The neuron-specific K+–Cl−cotransporter KCC2 extrudes Cl−and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2 activation is regulated at the transcriptional level and by unknown posttranslational mechanisms.
Peter, Blaesse +7 more
openaire +2 more sources