Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2
, 2013 International audienceIn healthy adults, activation of γ-aminobutyric acid (GABA) A and glycine receptors inhibits neurons as a result of low intracellular chloride concentration ([Cl-] i), which is maintained by the potassium chloride cotransporter KCC2.
Boulenguez, P. +8 more
core +1 more source
Protein Interactions Regulate KCC2-mediated Chloride Homeostasis [PDF]
, 2015 KCC2 is the primary Cl- cotransporter which maintains a low [Cl-]i required for inhibitory neurotransmission. Despite intense investigation into the mechanisms governing KCC2 regulation, the underlying mechanisms remain poorly understood.
Pressey, Jessica C.
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Transport-dependent and independent functions of KCC2 at excitatory synapses
, 2020 International audienceThis chapter explores non-canonical functions of the neuronal chloride/potassium KCC2 transporter at glutamatergic, excitatory synapses.
Al Awabdh, Sana +9 more
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WNK1/HSN2 isoform and the regulation of KCC2 activity [PDF]
Rare Diseases, 2013 Hereditary sensory and autonomic neuropathy type 2 is a rare autosomal recessive pathology presenting with early onset peripheral sensory defects. It arises from mutations affecting a specific isoform of the WNK1 kinase (with-no-lysine protein kinase 1) termed WNK1/HSN2. The role of WNK1 in the nervous system is not well understood. In our recent paper,
openaire +2 more sources
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.
PLoS ONE, 2020 The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang +6 more
doaj +1 more source
Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation
Frontiers in Molecular Neuroscience, 2023 The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature ...
Domenico Del Turco +8 more
doaj +1 more source
KCC2 Much Chloride Might Not Be the Only Problem [PDF]
Epilepsy Currents, 2019 [Box: see text]
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Phospho-dependent modulation of potassium chloride co-transporter KCC2 [PDF]
, 2009 The neuronal-specific potassium chloride co-transporter 2, KCC2, is a major chloride extruder in brain. The expression of KCC2 during neuronal development is fundamental to the switch of GABAergic response from excitatory to inhibitory. Malfunction of
Lee, H.C.
core
KCC2 membrane diffusion tunes neuronal chloride homeostasis [PDF]
Neuropharmacology, 2020 Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and ...
Côme, Etienne +3 more
openaire +3 more sources
Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model
Epilepsia, EarlyView.Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez +11 more
wiley +1 more source