Results 51 to 60 of about 5,407 (200)

KCC2 Much Chloride Might Not Be the Only Problem [PDF]

Epilepsy Currents, 2019
[Box: see text]
openaire   +2 more sources

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

, 2013
International audienceIn healthy adults, activation of γ-aminobutyric acid (GABA) A and glycine receptors inhibits neurons as a result of low intracellular chloride concentration ([Cl-] i), which is maintained by the potassium chloride cotransporter KCC2.
Boulenguez, P., Vinay, L., Liabeuf, Sophie, Bos, Rémi, Buttigieg, D., Sadlaoud, K., Brocard, C., Haase, G., Bras, H.   +8 more
core   +1 more source

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

Neurobiology of Disease, 2020
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV.
Aaron J. Barbour, Kurt F. Hauser, A. Rory McQuiston, Pamela E. Knapp   +3 more
doaj   +1 more source

WNK1/HSN2 isoform and the regulation of KCC2 activity [PDF]

Rare Diseases, 2013
Hereditary sensory and autonomic neuropathy type 2 is a rare autosomal recessive pathology presenting with early onset peripheral sensory defects. It arises from mutations affecting a specific isoform of the WNK1 kinase (with-no-lysine protein kinase 1) termed WNK1/HSN2. The role of WNK1 in the nervous system is not well understood. In our recent paper,
openaire   +2 more sources

KCC2 drives chloride microdomain formation in dendritic blebbing

Cell Reports, 2022
Intracellular chloride ion concentration ([Cl-]i) homeostasis is critical for excitatory/inhibitory balance and volume regulation in neurons. We quantitatively map spatiotemporal dendritic [Cl-]i dynamics during N-methyl-d-aspartate (NMDA) excitotoxicity to determine how Cl- changes contribute to localized dendritic swelling (blebbing) in stroke-like ...
Nicholas L. Weilinger, Leigh E. Wicki-Stordeur, Christopher J. Groten, Jeffrey M. LeDue, Kristopher T. Kahle, Brian A. MacVicar   +5 more
openaire   +2 more sources

Transport-dependent and independent functions of KCC2 at excitatory synapses

, 2020
International audienceThis chapter explores non-canonical functions of the neuronal chloride/potassium KCC2 transporter at glutamatergic, excitatory synapses.
Al Awabdh, Sana, Lévi, Sabine, Sabine Lévi, Jean Christophe Poncer, Sana Al Awabdh, Poncer, Jean Christophe, Quentin Chevy, Chevy, Quentin, Simonnet, Clémence, Clémence Simonnet   +9 more
core   +1 more source

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
doaj   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

Frontiers in Molecular Neuroscience, 2023
The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature ...
Domenico Del Turco, Mandy H. Paul, Jessica Schlaudraff, Julia Muellerleile, Fran Bozic, Mario Vuksic, Peter Jedlicka, Peter Jedlicka, Thomas Deller   +8 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source