Results 31 to 40 of about 5,407 (200)
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
Frontiers in Molecular Neuroscience, 2022 K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory responses mediated by γ-aminobutyric acid (GABA) type A receptors.
Kirill Zavalin +5 more
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The Expanding Therapeutic Potential of Neuronal KCC2 [PDF]
Cells, 2020 Dysfunctions in GABAergic inhibitory neural transmission occur in neuronal injuries and neurological disorders. The potassium–chloride cotransporter 2 (KCC2, SLC12A5) is a key modulator of inhibitory GABAergic inputs in healthy adult neurons, as its chloride (Cl−) extruding activity underlies the hyperpolarizing reversal potential for GABAA receptor Cl−
openaire +4 more sources
Cells, 2023 Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous
Erwan Pol +8 more
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Cell Reports, 2014 KCC2 is the neuron-specific K+-Cl− cotransporter required for maintaining low intracellular Cl−, which is essential for fast inhibitory synaptic transmission in the mature CNS.
Vivek Mahadevan +12 more
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NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]
Epilepsy Research, 2008 During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu +3 more
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NKCC1 and KCC2: Structural insights into phospho-regulation
Frontiers in Molecular Neuroscience, 2022 Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl– concentration in neurons.
Anna-Maria Hartmann +4 more
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Intracellular zinc inhibits KCC2 transporter activity [PDF]
Nature Neuroscience, 2009 We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons.
Michal, Hershfinkel +7 more
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Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus
IBRO Neuroscience Reports, 2022 In adults, γ-aminobutyric acid (GABA) type A receptor (GABAAR)-mediated inhibition depends on the maintenance of low intracellular chloride anion concentration through neuron-specific potassium-chloride cotransporter-2 (KCC2).
Lulan Chen +12 more
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KCC2 downregulation after sciatic nerve injury enhances motor function recovery
Scientific Reports, 2023 Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling.
Dennis Lawrence Cheung +8 more
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Molecular Pain, 2022 GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K + -Cl - -cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function. However, few reports have
Yuan Gao +9 more
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