Results 31 to 40 of about 5,952 (193)
Cell Reports, 2014 KCC2 is the neuron-specific K+-Cl− cotransporter required for maintaining low intracellular Cl−, which is essential for fast inhibitory synaptic transmission in the mature CNS.
Vivek Mahadevan +12 more
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The Expanding Therapeutic Potential of Neuronal KCC2 [PDF]
Cells, 2020 Dysfunctions in GABAergic inhibitory neural transmission occur in neuronal injuries and neurological disorders. The potassium–chloride cotransporter 2 (KCC2, SLC12A5) is a key modulator of inhibitory GABAergic inputs in healthy adult neurons, as its chloride (Cl−) extruding activity underlies the hyperpolarizing reversal potential for GABAA receptor Cl−
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Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus
IBRO Neuroscience Reports, 2022 In adults, γ-aminobutyric acid (GABA) type A receptor (GABAAR)-mediated inhibition depends on the maintenance of low intracellular chloride anion concentration through neuron-specific potassium-chloride cotransporter-2 (KCC2).
Lulan Chen +12 more
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KCC2 downregulation after sciatic nerve injury enhances motor function recovery
Scientific Reports, 2023 Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling.
Dennis Lawrence Cheung +8 more
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NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus [PDF]
Epilepsy Research, 2008 During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons.
Lei, Zhu +3 more
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Molecular Pain, 2022 GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K + -Cl - -cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function. However, few reports have
Yuan Gao +9 more
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NKCC1 and KCC2: Structural insights into phospho-regulation
Frontiers in Molecular Neuroscience, 2022 Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl– concentration in neurons.
Anna-Maria Hartmann +4 more
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Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes
Cell Reports, 2019 Summary: The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling. This raises questions about whether neural processing is comparably altered. Here, we test whether the K+-Cl−
Josiane C.S. Mapplebeck +7 more
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Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function
Frontiers in Molecular Neuroscience, 2019 GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of ...
Yvonne E. Moore +7 more
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Frontiers in Molecular Neuroscience, 2022 GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann +6 more
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