Results 31 to 40 of about 8,156 (210)
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
eLife, 2017 KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis
Vivek Mahadevan +12 more
doaj +1 more source
Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus
IBRO Neuroscience Reports, 2022 In adults, γ-aminobutyric acid (GABA) type A receptor (GABAAR)-mediated inhibition depends on the maintenance of low intracellular chloride anion concentration through neuron-specific potassium-chloride cotransporter-2 (KCC2).
Lulan Chen +12 more
doaj +1 more source
Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]
, 2015 Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F +64 more
core +2 more sources
KCC2 downregulation after sciatic nerve injury enhances motor function recovery
Scientific Reports, 2023 Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling.
Dennis Lawrence Cheung +8 more
doaj +1 more source
NKCC1 and KCC2: Structural insights into phospho-regulation
Frontiers in Molecular Neuroscience, 2022 Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl– concentration in neurons.
Anna-Maria Hartmann +4 more
openaire +3 more sources
Molecular Pain, 2022 GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K + -Cl - -cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function. However, few reports have
Yuan Gao +9 more
doaj +1 more source
KCC2 drives chloride microdomain formation in dendritic blebbing
Cell Reports, 2022 Intracellular chloride ion concentration ([Cl-]i) homeostasis is critical for excitatory/inhibitory balance and volume regulation in neurons. We quantitatively map spatiotemporal dendritic [Cl-]i dynamics during N-methyl-d-aspartate (NMDA) excitotoxicity to determine how Cl- changes contribute to localized dendritic swelling (blebbing) in stroke-like ...
Nicholas L. Weilinger +5 more
openaire +2 more sources
A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation [PDF]
, 2014 Genetic variation in SLC12A5 which encodes KCC2, the neuron‐specific cation‐chloride cotransporter that is essential for hyperpolarizing GABAergic signaling and formation of cortical dendritic spines, has not been reported in human disease.
Ahmad, Faraz +14 more
core +2 more sources
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes
Cell Reports, 2019 Summary: The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling. This raises questions about whether neural processing is comparably altered. Here, we test whether the K+-Cl−
Josiane C.S. Mapplebeck +7 more
doaj +1 more source
Molecular architecture of potassium chloride co-transporter KCC2 [PDF]
Scientific Reports, 2017 AbstractKCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. Despite significant accumulating data on the biology and electrophysiological properties of KCC2, structure-function relationships ...
Agez, Morgane +18 more
openaire +3 more sources