Results 21 to 30 of about 5,407 (200)
Journal of Neurophysiology, 2001 KCC2 is one of four known isoforms of the K-Cl cotransporter with an expression pattern restricted to neurons. It mediates efflux of Cl− across neuronal membranes and plays an important role in GABAergic and glycinergic neurotransmission. To understand the molecular basis for neuronal specificity of KCC2 expression, we isolated and sequenced portions ...
M F, Karadsheh, E, Delpire
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Distribution and Cellular Localization of KCC2 in the Ferret Neocortex
Developmental Neuroscience, 2018 KCC2 (a brain-specific potassium-chloride cotransporter) affects development of the cerebral cortex, including aspects of neuronal migration and cellular maturation and differentiation. KCC2 also modulates chloride homeostasis by influencing the switch of GABA from depolarizing in young neurons to hyperpolarizing in mature neurons.
Francis T, Djankpa +2 more
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Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function [PDF]
Frontiers in Neurology, 2020 As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu +13 more
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Enhancing KCC2 function counteracts morphine-induced hyperalgesia [PDF]
Scientific Reports, 2017 AbstractMorphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial dorsal horn (SDH) of the spinal cord, weakening spinal GABAA/glycine-mediated ...
Francesco Ferrini +4 more
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The Multifaceted Roles of KCC2 in Cortical Development [PDF]
Trends in Neurosciences, 2021 KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice
Virtanen, Mari A. +4 more
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BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia
Translational Neuroscience, 2015 Abstract Purpose: To investigate the effect of brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase (Trk) on potassium chloride cotransporter 2 (KCC2) in rats following nicotine withdrawal and the roles played by BDNF/Trk/KCC2 pathway in nicotine withdrawal-induced hyperalgesia.
Shi Wenhui +5 more
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Frontiers in Cell and Developmental Biology, 2022 KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and ...
Francis J. Prael III +12 more
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Cells, 2022 KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated.
Anastasia Rigkou +3 more
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iScience, 2022 Summary: Modulation of the neuronal K+/Cl− cotransporter 2 (KCC2) activity, which mediates Cl− export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an ...
Hila Asraf +5 more
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Life, 2021 A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are ...
Vitaliy E. Kalashnikov +6 more
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