Results 21 to 30 of about 5,952 (193)
Distribution and Cellular Localization of KCC2 in the Ferret Neocortex
Developmental Neuroscience, 2018 KCC2 (a brain-specific potassium-chloride cotransporter) affects development of the cerebral cortex, including aspects of neuronal migration and cellular maturation and differentiation.
Oluwole B. Akinola +2 more
core +3 more sources
Journal of Neurophysiology, 2001 KCC2 is one of four known isoforms of the K-Cl cotransporter with an expression pattern restricted to neurons. It mediates efflux of Cl− across neuronal membranes and plays an important role in GABAergic and glycinergic neurotransmission.
E. Delpire, Michael F. Karadsheh
core +3 more sources
Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function [PDF]
Frontiers in Neurology, 2020 As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu +13 more
doaj +3 more sources
The Multifaceted Roles of KCC2 in Cortical Development [PDF]
Trends in Neurosciences, 2021 KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice
Virtanen, Mari A. +4 more
+7 more sources
Frontiers in Cell and Developmental Biology, 2022 KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and ...
Francis J. Prael III +12 more
doaj +1 more source
Cells, 2022 KCC2 mediates extrusion of K+ and Cl− and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated.
Anastasia Rigkou +3 more
doaj +1 more source
iScience, 2022 Summary: Modulation of the neuronal K+/Cl− cotransporter 2 (KCC2) activity, which mediates Cl− export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an ...
Hila Asraf +5 more
doaj +1 more source
Life, 2021 A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are ...
Vitaliy E. Kalashnikov +6 more
doaj +1 more source
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
Frontiers in Molecular Neuroscience, 2022 K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory responses mediated by γ-aminobutyric acid (GABA) type A receptors.
Kirill Zavalin +5 more
doaj +1 more source
Cells, 2023 Na-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABAA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous
Erwan Pol +8 more
doaj +1 more source