Results 91 to 100 of about 8,156 (210)

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing [PDF]

, 2016
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition.
Beggs, S, Dedek, A, Hildebrand, ME, Li, Y, Lombroso, PJ, Salter, MW, Sengar, AS, Xu, J   +7 more
core   +1 more source

N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation [PDF]

Journal of Biological Chemistry, 2017
K+/Cl- cotransporter 2 (KCC2) is selectively expressed in the adult nervous system and allows neurons to maintain low intracellular Cl- levels. Thus, KCC2 activity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated by type A γ-aminobutyric acid (GABAA) receptors, which are Cl--permeable, ligand-gated ion channels ...
Leslie C, Conway, Ross A, Cardarelli, Yvonne E, Moore, Karen, Jones, Lisa J, McWilliams, David J, Baker, Matthew P, Burnham, Roland W, Bürli, Qi, Wang, Nicholas J, Brandon, Stephen J, Moss, Tarek Z, Deeb   +11 more
openaire   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2 [PDF]

, 2017
A plethora of neurological disorders are associated with alterations in the expression and localization of potassium-chloride cotransporter type 2 (KCC2), making KCC2 a critical player in neuronal function and an attractive target for therapeutic ...
Agez, Morgane, Friedel, Perrine, Jawhari, Anass, Ludwig, Anastasia, Medina, Igor, Pellegrino, Christophe, Rivera Baeza, Juan Claudio   +6 more
core   +3 more sources

Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

Neural Plasticity, 2011
The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons.
Anastasia Ludwig, Pavel Uvarov, Christophe Pellegrino, Judith Thomas-Crusells, Sebastian Schuchmann, Mart Saarma, Matti S. Airaksinen, Claudio Rivera   +7 more
doaj   +1 more source

¬Immunolocalization of cation-chloride cotransporters in the developing and mature spinal cord of opossums, Monodelphis domestica

Frontiers in Neuroanatomy, 2013
Spinal inhibition is required to generate coordinated outputs between antagonistic muscles during locomotion. It relies on low neuronal chloride concentration set by two cation-chloride cotransporters, NKCC1 and KCC2 which, respectively, pumps Cl- in or ...
Ha-Loan ePhan, Jean-François ePflieger
doaj   +1 more source

Impact of Anesthesia With Propofol on Epileptic Discharges Recorded by Stereo‐Electroencephalography in Pediatric Epilepsy Surgery

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
The number of spikes decreased under anesthesia, particularly within the SOZ, while HFOs increased under anesthesia. However, the extent of the increase did not differ between the SOZ and NSOZ. The number of HFOs appeared to be a more reliable interictal biomarker in ioEEG, particularly in the frontal cortex and cingulate cortex, and was not influenced
Chang Liu, Ping Ding, Tong Zhao, Tinghong Liu, Shijie Wu, Yuxiang Yan, Liu Yuan, Liwei Zhang, Shuli Liang   +8 more
wiley   +1 more source

Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. [PDF]

, 2015
BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks.
Dobolyi, Arpád, Héja, László, Kardos, Julianna, Pál, Ildikó   +3 more
core   +1 more source

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Scientific Reports, 2017
The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations ...
Anna Doshina, Florian Gourgue, Michiho Onizuka, Remi Opsomer, Peng Wang, Kunie Ando, Bernadette Tasiaux, Ilse Dewachter, Pascal Kienlen-Campard, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot   +12 more
doaj   +1 more source

Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation

Frontiers in Cellular Neuroscience, 2019
Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures thought to arise from impaired balance between neuronal excitation and inhibition.
Phan Q. Duy, Phan Q. Duy, Wyatt B. David, Kristopher T. Kahle, Kristopher T. Kahle, Kristopher T. Kahle, Kristopher T. Kahle, Kristopher T. Kahle   +7 more
doaj   +1 more source