Results 91 to 100 of about 5,952 (193)
Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures
, 2018 /SummaryEfficacious neuronal inhibition is sustained by the neuronal K+Cl- co-transporter KCC2, and loss of KCC2 function through injury or mutation is associated with altered GABAergic signalling and neuronal seizures.
AJ Moorhouse +15 more
core +1 more source
KCC2 escape from neuropathic pain [PDF]
Science-Business eXchange, 2013 Researchers from Laval University have described an activator of the co-transporter KCC2 and shown its analgesic effect in mice. The group is developing next-generation compounds with better pharmacological properties.
openaire +1 more source
Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons
Neural Plasticity, 2011 The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons.
Anastasia Ludwig +7 more
doaj +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, Volume 4, Issue 2, June 2026.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source
PLoS Genetics, 2013 Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare pathology characterized by an early onset of severe sensory loss (all modalities) in the distal limbs.
Valérie Bercier +6 more
doaj +1 more source
Co-immunoprecipitation reveals interaction between KCC3 and KCC2.
, 2013 Xenopus laevis oocytes were injected with KCC2 cRNA in the presence or absence of wild-type KCC3 or KCC3-E289G cRNAs. KCC2 or KCC3 were then immunoprecipitated and the complex was analyzed by Western blot analysis using rabbit polyclonal anti-KCC2 or ...
Jinlong Ding (399034) +2 more
core +1 more source
Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
Frontiers in Cellular Neuroscience, 2015 Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl- cotransporter (KCC2) in the CNS. Efficient KCC2 transport is essential for setting the neuronal Cl- gradient, which is required for fast GABAergic inhibition.
Vivek eMahadevan +12 more
doaj +1 more source
Kloridinkuljetusproteiini KCC2:n ilmentyminen monoamiineja tuottavissa neuroneissa
, 2016 Tutkimuksen tavoitteena on immunohistokemian menetelmien avulla selvittää kloridinkuljetusproteiini KCC2:n ilmentymistä monoamiinisoluissa keskushermostossa.
Heiska, Ensi
core
Data_Sheet_1_M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.PDF
, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan (11826) +6 more
core +1 more source
, 2022 KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and ...
Francis J. Prael III (12917138) +6 more
core +1 more source