Results 111 to 120 of about 5,952 (193)

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures

Frontiers in Neuroscience
IntroductionKetogenic diet (KD), a high-fat, low-carbohydrate, and adequate protein diet, is a non-pharmacological treatment for refractory epilepsy. However, their mechanism of action is not fully understood.
Leticia Granados-Rojas, Leonardo Hernández-López, Emmanuel Leonardo Bahena-Alvarez, Tarsila Elizabeth Juárez-Zepeda, Verónica Custodio, Joyce Graciela Martínez-Galindo, Karina Jerónimo-Cruz, Miguel Tapia-Rodríguez, America Vanoye-Carlo, Pilar Duran, Carmen Rubio   +10 more
doaj   +1 more source

KCC2 as a multifunctional protein in brain development and disease [PDF]

, 2013
Active extrusion of Cl- from the neuronal cytoplasm by the neuron-specific K-Cl co-transporter isoform KCC2 is necessary for the hyperpolarizing inhibitory Cl- currents mediated by the GABA receptors (GABAARs). Early in development and following cellular
Puskarjov, Martin
core  

Chloride Channels in Amyotrophic Lateral Sclerosis

Acta Medica Bulgarica
In amyotrophic lateral sclerosis (ALS), human postmortem transcriptomics reveals a consistent shift, with downregulation of neuronal genes and upregulation of glial and inflammatory programs. This establishes a framework where inhibitory synapses and ion
Tourtourikov I., Mitev V., Todorova A.
doaj   +1 more source

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q

Frontiers in Molecular Neuroscience
IntroductionThe potassium chloride co-transporter 2 (KCC2) is the principal Cl− extrusion mechanism employed by mature neurons in the central nervous system (CNS) and plays a critical role in determining the efficacy of fast synaptic inhibition mediated ...
Jinglin Ji, Catherine Choi, Christopher E. Bope, Jacob S. Dengler, Stephen J. Moss, Joshua L. Smalley   +5 more
doaj   +1 more source

Phospho-dependent modulation of potassium chloride co-transporter KCC2.

The neuronal-specific potassium chloride co-transporter 2, KCC2, is a major chloride extruder in brain. The expression of KCC2 during neuronal development is fundamental to the switch of GABAergic response from excitatory to inhibitory.
Lee, H.C.
core  

The Informational Blackout chronic pain and fatigue as rational outputs of a brain operating on degraded biological signals. [PDF]

Front Pain Res (Lausanne)
Pandolfi-Cuadrado C.
europepmc   +1 more source

Ginsenoside Rh1 Modulates GABAergic Inhibitory Homeostasis and Mitochondrial Quality Control During Lead (Pb)-Associated Neuronal Dysfunction. [PDF]

Molecules
Li X, Wang T, Mo L, Cao H, Lv Z, Yu J, Liu S, Sun Y, Chen T.   +8 more
europepmc   +1 more source

Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature. [PDF]

Cell Commun Signal
De Rosa F, Kilb W, Luhmann HJ, Sinning A.   +3 more
europepmc   +1 more source

WNK-SPAK-NKCC1/KCC2 pathway disrupts chloride homeostasis and drives hyperactivation of PVN-CRH neurons in essential hypertension. [PDF]

iScience
Guo X, Ma H, Zhao Q, Zhang Y, Yang P, Zhao Q, Jia L, Zhang L, Guan Y, Zhang Y, Miao S, Ma H.   +11 more
europepmc   +1 more source

Sex-Specific Mechanisms of Central Sensitization: A Narrative Review of the Neuroimmune Architecture of Chronic Pain. [PDF]

Cureus
Andrade Pereira D.
europepmc   +1 more source