Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo +2 more
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Subunit Composition of Neurotransmitter Receptors in the Immature and in the Epileptic Brain [PDF]
, 2014 Neuronal activity is critical for synaptogenesis and the development of neuronal networks. In the immature brain excitation predominates over inhibition facilitating the development of normal brain circuits, but also rendering it more susceptible to ...
Loddenkemper, Tobias +1 more
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WNK1/HSN2 isoform and the regulation of KCC2 activity [PDF]
Rare Diseases, 2013 Hereditary sensory and autonomic neuropathy type 2 is a rare autosomal recessive pathology presenting with early onset peripheral sensory defects. It arises from mutations affecting a specific isoform of the WNK1 kinase (with-no-lysine protein kinase 1) termed WNK1/HSN2. The role of WNK1 in the nervous system is not well understood. In our recent paper,
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Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
Frontiers in Cellular Neuroscience, 2015 Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl- cotransporter (KCC2) in the CNS. Efficient KCC2 transport is essential for setting the neuronal Cl- gradient, which is required for fast GABAergic inhibition.
Vivek eMahadevan +12 more
doaj +1 more source
Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction
Brain Research, 2019 SLC12A5 encodes K+-Cl- cotransporter 2 (KCC2), which is the main Cl- extruder of neurons, and renders the proper inhibitory function of the neurotransmitters γ-aminobutyric acid (GABA) and glycine. Thus, any variant in SLC12A5, if it causes dysfunction of KCC2, could be pathogenic for neurological and psychiatric disorders by disrupting inhibition and ...
Atsuo Fukuda, Miho Watanabe
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Research on ionic homeostatic equilibrium may change our view about epilepsy [PDF]
, 2013 Universidade Federal de Sao Joao Del Rei (UFSJ) Departamento de Engenharia de Biossistemas (DEPEB) Laboratorio de Neurociencia Experimental e Computacional Dr Aristides Azevedo Pacheco LeaoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de ...
Almeida, Antonio Carlos G. de +4 more
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WNK Kinase Signaling in Ion Homeostasis and Human Disease [PDF]
, 2017 This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters
Delpire, Eric +5 more
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Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain
Cell Reports, 2016 Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying ...
Lingyong Li +6 more
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MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology [PDF]
, 2018 Indexación: Scopus.1Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Santiago, Chile, 2National Institute of Environmental Health ...
Aguayo, F.I. +12 more
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Generation and Characterization of the Cation-Chloride Cotransporter KCC2 Hypomorphic Mouse [PDF]
, 2006 The cation-Cl- cotransporter (CCC) family comprises of Na+-Cl- cotransporter (NCC), Na+-K+-2Cl- cotransporters (NKCC1-2), and four K+-Cl- cotransporters (KCC1-4).
Tornberg, Janne
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