Results 121 to 130 of about 8,156 (210)

Hypothalamic Signaling Mechanisms in Hypertension [PDF]

, 2015
The etiology of hypertension, a critical public health issue affecting one in three US adults, involves the integration of the actions of multiple organ systems, including the central nervous system.
Casey Y. Carmichael, Richard D. Wainford
core   +1 more source

The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl− extrusion

iScience
Summary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is ...
Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss   +11 more
doaj   +1 more source

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. [PDF]

, 2019
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality.
Carromeu, Cassiano, Freitas, Beatriz CG, Ghosh, Anirvan, Hu, Xindao, Kim, Jean J, Lavallée-Adam, Mathieu, Miller, Meghan T, Muotri, Alysson R, Savas, Jeffrey N, Yates, John R   +9 more
core   +2 more sources

Inflammation alters cation chloride cotransporter expression in sensory neurons

Neurobiology of Disease, 2004
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza, Naomi L. Chillingworth, John A. Payne, Lucy F. Donaldson   +3 more
doaj   +1 more source

Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells. [PDF]

, 2012
International audienceNeuronal chloride concentration ([Cl(-)](i)) is known to be dynamically modulated and alterations in Cl(-) homeostasis may occur in the brain at physiological and pathological conditions, being also likely involved in glioma-related
Antonio eFrancioso, Cristina eBertollini, Cristina eLimatola, Cristina eLimatola, Davide eRagozzino, Davide eRagozzino, Emanuele eMurana, Federico eScala, Luciana eMosca, Maria eD'Erme, Myriam eCatalano, Myriam eCatalano, Piotr eBregestovski, Silvia eDi Angelantonio   +13 more
core   +4 more sources

KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Acta Neuropathologica Communications, 2019
Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay in RTT patients’
Lisa Hinz, Joan Torrella Barrufet, Vivi M. Heine   +2 more
doaj   +1 more source

A Comparison of Continuously Controlled and Controlled K-theory

, 1994
We define an unreduced version of the e-controlled lower $K$-theoretic groups of Ranicki and Yamasaki, and Quinn. We show that the reduced versions of our groups coincide (in the inverse limit and its first derived, $\lim^1$) with those of Ranicki and ...
Anderson, Douglas R., Connolly, Francis X., Munkholm, Hans J.   +2 more
core   +1 more source

Entangling two Bose Einstein condensates in a double cavity system

, 2010
We propose a scheme to transfer the quantum state of light fields to the collective density excitations of a Bose Einstein condensate (BEC) in a cavity.
Aranya B Bhattacherjee, Bhattacherjee A, Bogoliubov N N, Deb B Agarwal G S, Griessner A, ManMohan, , Ng H T, Parkin A S, Pinard M, Priyanka Verma, Tarun Kumar, Walls D F, Werner R F   +12 more
core   +1 more source

Chloride Channels in Amyotrophic Lateral Sclerosis

Acta Medica Bulgarica
In amyotrophic lateral sclerosis (ALS), human postmortem transcriptomics reveals a consistent shift, with downregulation of neuronal genes and upregulation of glial and inflammatory programs. This establishes a framework where inhibitory synapses and ion
Tourtourikov I., Mitev V., Todorova A.
doaj   +1 more source

SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons

iScience
Inhibitory synaptic neurotransmission mediated by GABA requires a low concentration of chloride ions (Cl-) in neurons, which is established and maintained by the potassium-chloride co-transporter 2 (KCC2). While KCC2-interacting proteins are known to regulate KCC2 protein level and function, specific KCC2-interacting partners are still being identified
Vineeth Andisseryparambil Raveendran, Melissa Serranilla, Azam Asgarihafshejani, Miranda de Saint-Rome, Mariia Cherednychenko, Shanelle Mullany, Jennifer A. Mitchell, Jessica C. Pressey, Melanie A. Woodin   +8 more
openaire   +2 more sources