Results 101 to 110 of about 5,952 (193)
NKCC1 and KCC2 Expression in DLPFC.
, 2015 Expression of Na-K-Cl cotransporter (NKCC1) (A, D) and K-Cl cotransporter (KCC2) (B, E) protein in the DLPFC in control subjects (CTL) and subjects with schizophrenia (SCZ) (A, B) and in subjects with schizophrenia on and off medication for at least 6 ...
Courtney R. Sullivan (715337) +4 more
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Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain
Cell Reports, 2016 Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying ...
Lingyong Li +6 more
doaj +1 more source
iScienceSummary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is ...
Noell Cho +11 more
doaj +1 more source
Chloride cotransporter KCC2 is essential for GABAergic inhibition in the SCN
Neuropharmacology, 2018 One of the principal neurotransmitters of the central nervous system is GABA. In the adult brain, GABA is predominantly inhibitory, but there is growing evidence indicating that GABA can shift to excitatory action depending on environmental conditions.
Engberink, A.H.O.O. +2 more
openaire +4 more sources
Seizure-induced alterations in NKCC1 and KCC2 protein levels.
, 2013 Using Western Blot, NKCC1 and KCC2 protein levels were assessed in cortical and hippocampal tissue obtained from P10 rats at 1, 12, 24, 48, and 168 hr after hypoxia-induced seizures (HS), and compared to age-matched littermate controls. Optical densities
Kristopher T. Kahle (337479) +11 more
core +1 more source
Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
Frontiers in Cellular Neuroscience, 2014 In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i).
Igor eMedina +13 more
doaj +1 more source
Post-translational regulation of KCC2 in the rat hippocampus [PDF]
, 2012 KCC2 is an important K+-Cl- co-transporter that along with Na+-K+-2Cl- co-transporter, NKCC1 is largely responsible for the regulation of intracellular chloride concentration in neurons which determines whether the ionotropic GABAergic/glycinergic ...
Ahmad, Faraz
core
Effect of E289G-like mutations in KCC2 and NKCC1.
, 2013 K+ influx was measured through unidirectional 86Rb tracer uptake in oocytes injected with water, wild-type KCC2 or KCC2-E201G or KCC2-E201D mutant cRNAs, and wild-type or NKCC1-E383G or NKCC1-E383D mutant cRNAs. Uptakes were measured under isosmotic (200
Jinlong Ding (399034) +2 more
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KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients
Acta Neuropathologica Communications, 2019 Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay in RTT patients’
Lisa Hinz +2 more
doaj +1 more source
Structural and functional roles of KCC2 in developing cortex [PDF]
, 2008 Cation chloride cotransporters (CCCs) are critical for controlling intracellular chloride homeostasis. The CCC family is composed of four isoforms of K-Cl cotransporters (KCC1-4), two isoforms of Na-K-2Cl cotransporters (NKCC1-2), one Na-Cl cotransporter
Li, Hong
core