Food Frontiers, Volume 7, Issue 1, January 2026.This study investigates whether gestational probiotic and vitamin D supplementation can mitigate CPF effects in Wistar rats. While supplementation did not reverse CPF‐induced deficits, it induced notable neurodevelopmental changes in control animals, underscoring the need for further research on prenatal supplementation safety.
Mario Coca +8 more
wiley +1 more source
Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum [PDF]
, 2012 Disruption of the potassium/chloride cotransporter 3 (KCC3), encoded by the SLC12A6 gene, causes hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder ...
Dion, Patrick A. +15 more
core +1 more source
Traumatic Brain Injury Temporal Proteome Guides KCC2-Targeted Therapy
Journal of Neurotrauma, 2019 Advancing therapeutics for traumatic brain injury (TBI) remains a challenge, necessitating testable targets with interventions appropriately timed to intercede on evolving secondary insults. Neuroproteomics provides a global molecular approach to deduce the complex post-translational processes that underlie secondary events after TBI.
Pavel N, Lizhnyak +4 more
openaire +3 more sources
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt [PDF]
, 2017 Background The developmental transition from depolarizing to hyperpolarizing γ-aminobutyric acid-mediated neurotransmission is primarily mediated by an increase in the amount of the potassium-chloride cotransporter KCC2 during early postnatal life ...
Bodogan, T. +6 more
core
NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons [PDF]
, 2015 GABA A receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular
Bosch, Ludo Van Den +3 more
core +1 more source
Beyond ion transport: KCC2 makes cells walk and talk [PDF]
The Journal of Physiology, 2011 Tumour cells often express a repertoire of genes unusual for the cell lineage from which they originate. It is not surprising that these genes include ion channels and transporters, but because biophysicists are rarely interested in cancer biology, and scientists working on cancer often shy away from ion transport physiology, specific functions of ...
openaire +2 more sources
PLoS Genetics, 2013 Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare pathology characterized by an early onset of severe sensory loss (all modalities) in the distal limbs.
Valérie Bercier +6 more
doaj +1 more source
Neural Plasticity, Volume 2026, Issue 1, 2026.Over the past 40 years, increasing demand for spinal cord injury (SCI) repair strategies has driven extensive research, yet critical recovery mechanisms remain poorly understood. Key gaps include the temporary loss of spinal reflexes during spinal shock and the dynamics of “injury potentials,” which spread rapidly from the impact site, similar to ...
Mariia E. Ermolaeva +4 more
wiley +1 more source
Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo [PDF]
, 2006 Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear.
Akerman, C. J., Cline, H. T.
core +1 more source
KCC2 Much Chloride Might Not Be the Only Problem [PDF]
Epilepsy Currents, 2019 [Box: see text]
openaire +2 more sources