Results 81 to 90 of about 8,156 (210)

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]

, 2017
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder, Berdondini, Luca, De Pietri Tonelli, Davide, Marinaro, Federica   +3 more
core   +2 more sources

KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation [PDF]

The Journal of Neuroscience, 2015
Expression of the neuronal K/Cl transporter KCC2 is tightly regulated throughout development and by both normal and pathological neuronal activity. Changes in KCC2 expression have often been associated with altered chloride homeostasis and GABA signaling.
Quentin Chevy, Martin Heubl, Marie Goutierre, Stéphanie Backer, Imane Moutkine, Emmanuel Eugène, Evelyne Bloch-Gallego, Sabine Lévi, Jean Christophe Poncer   +8 more
openaire   +3 more sources

Structural and functional roles of KCC2 in developing cortex [PDF]

, 2008
Cation chloride cotransporters (CCCs) are critical for controlling intracellular chloride homeostasis. The CCC family is composed of four isoforms of K-Cl cotransporters (KCC1-4), two isoforms of Na-K-2Cl cotransporters (NKCC1-2), one Na-Cl cotransporter
Li, Hong
core  

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors

The Journal of Physiology, Volume 604, Issue 7, Page 3077-3093, 1 April 2026.
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi, Caterina Ciani, Francesca Emma Mongelli, Rashid Giniatullin, Carmen Falcone, Giuliano Taccola   +5 more
wiley   +1 more source

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo [PDF]

, 2017
The neuron-specific K-Cl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in pyramidal neurons, and recent in vitro data suggest that this protein plays a role in the development of dendritic spines.
Belem, Bebyanda JT, Blaesse, Peter, Briner, Adrian, Dayer, Alex G., Fiumelli, Hubert, Kaila, Kai, Martin, Jean-Luc, Puskarjov, Martin, Vutskits, Laszlo   +8 more
core  

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures [PDF]

, 2015
The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions.
A McKenna, A McTague, AM Hartmann, AR Quinlan, C Rivera, CA Hübner, CA Hübner, DS Hekmat-Scafe, EF Pettersen, G Barcia, H Ashkenazy, H Fiumelli, H Li, I Chamma, I Chamma, J Söding, J Tornberg, K Wang, KJ Staley, KT Kahle, M Puskarjov, MA DePristo, MJ Sippl, MY Shen, N Eswar, NS Woo, P Blaesse, P Striano, PL Shaffer, RL Dunbrack Jr, S Vanhatalo, SK Chung, SP Antrobus, T Sakuma, W Hoch, Y Ben-Ari   +35 more
core   +2 more sources

Spreading depolarization and its influence on epileptiform activity

Epilepsia, Volume 67, Issue 3, Page 1078-1089, March 2026.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, Volume 38, Issue 11, 20 February 2026.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source