Results 81 to 90 of about 5,952 (193)
Frontiers in Neuroanatomy, 2013 Spinal inhibition is required to generate coordinated outputs between antagonistic muscles during locomotion. It relies on low neuronal chloride concentration set by two cation-chloride cotransporters, NKCC1 and KCC2 which, respectively, pumps Cl- in or ...
Ha-Loan ePhan, Jean-François ePflieger
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Developmental Neurobiology, Volume 86, Issue 3, July 2026.ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha +3 more
wiley +1 more source
NCBE is colocalized with KCC2.
, 2012 A–C, Projections (3 µm) of NCBE WT retinal sections stained for NCBE (A, C, green) and the chloride extruder KCC2 (B, C, magenta). Higher magnification of single scans (0.5 µm) of NCBE WT retinal sections double-stained for NCBE (D, F, green) and KCC2 (E,
Naoyuki Tanimoto (32417) +11 more
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Rethinking GABAergic therapy in neonatal seizures: Beyond Scylla and Charybdis
Epilepsia Open, EarlyView.
Raffaele Falsaperla +2 more
wiley +1 more source
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
MedComm, Volume 7, Issue 7, July 2026.Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
Expression and functions of KCC2 in the perinatal rodent cortex [PDF]
, 2020 KCC2 is the main neuronal K-Cl cotransporter, which lowers the intracellular Cl- concentration and thus maintains GABAA receptor-mediated inhibition during network activity in mature neurons.
Mavrovic, Martina
core
Enhancing KCC2 function counteracts morphine-induced hyperalgesia [PDF]
Scientific Reports, 2017 AbstractMorphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial dorsal horn (SDH) of the spinal cord, weakening spinal GABAA/glycine-mediated ...
Francesco Ferrini +4 more
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Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission
Scientific Reports, 2017 The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations ...
Anna Doshina +12 more
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Frontiers in Cellular Neuroscience, 2019 Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures thought to arise from impaired balance between neuronal excitation and inhibition.
Phan Q. Duy +7 more
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The Journal of Physiology, Volume 604, Issue 14, Page 5711-5730, 15 July 2026.Abstract figure legend Pregestational stress modifies germ‐cell epigenetic information, resulting in GABAergic dysfunction and E/I imbalance in the developing brain, thereby increasing susceptibility to ASD‐and ADHD‐related neurodevelopmental abnormalities in offspring.
Samaneh Ahmadian‐Moghadam +2 more
wiley +1 more source