Results 51 to 60 of about 8,301 (197)

NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels

Journal of Neuroinflammation, 2022
Background Hydrocephalus is a severe complication of intracerebral hemorrhage with ventricular extension (ICH-IVH) and causes cerebrospinal fluid (CSF) accumulation.
Zhao-rui Zhang, Q. Tan, Peiwen Guo, Suna Huang, Zhengcai Jia, Xin Liu, Hua Feng, Yujie Chen   +7 more
semanticscholar   +1 more source

Impact of Hybrid and Complex N-Glycans on Cell Surface Targeting of the Endogenous Chloride Cotransporter Slc12a2

International Journal of Cell Biology, 2015
The Na+K+2Cl− cotransporter-1 (Slc12a2, NKCC1) is widely distributed and involved in cell volume/ion regulation. Functional NKCC1 locates in the plasma membrane of all cells studied, particularly in the basolateral membrane of most polarized cells ...
Richa Singh, Mohammed Mashari Almutairi, Romario Pacheco-Andrade, Mohamed Y. Mahmoud Almiahuob, Mauricio Di Fulvio   +4 more
doaj   +1 more source

In silico identification of potential inhibitors with higher potency than bumetanide targeting NKCC1: An important ion co-transporter to treat neurological disorders

Informatics in Medicine Unlocked, 2021
Na + -K + -2Cl-cotransporter 1 (NKCC1) plays an important role in intracellular ionic homeostasis and cell volume regulation in the brain. Pathological activation of brain NKCC1 is associated with many brain disorders, including ischemic stroke ...
Arpita Singha Roy, Md Sad Salabi Sawrav, Md Shahadat Hossain, Fatema Tuz Johura, Sk. Faisal Ahmed, Ithmam Hami, Md Kobirul Islam, Hasan Al Reza, Mohammad Iqbal H. Bhuiyan, Newaz Mohammed Bahadur, Md Mizanur Rahaman   +10 more
doaj   +1 more source

COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination

American Journal of Physiology-Cell Physiology, 2013
Mice deficient in Na-K-2Cl cotransporter (NKCC1) have been generated by targeted disruption of the gene encoding NKCC1 involving the carboxy terminus (CT-NKCC1) but not the amino terminus. We hypothesize that the resulting physiological defects are due to loss of proteins interacting with CT-NKCC1.
Laura, Smith, Paul, Litman, Carole M, Liedtke   +2 more
openaire   +3 more sources

Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling

Science Advances, 2022
The Na-K-2Cl cotransporter-1 (NKCC1) is an electroneutral Na+-dependent transporter responsible for simultaneously translocating Na+, K+, and Cl− ions into cells. In human tissue, NKCC1 plays a critical role in regulating cytoplasmic volume, fluid intake,
M. Moseng, C. Su, Kerri Rios, Meng Cui, M. Lyu, Przemysław Glaza, P. Klenotic, E. Delpire, E. Yu   +8 more
semanticscholar   +1 more source

NKCC1-deficiency results in abnormal proliferation of neural progenitor cells of the lateral ganglionic eminence

Frontiers in Cellular Neuroscience, 2016
The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter NKCC1 is important for regulating cell volume and the proliferation of different cell types in vitro.
Ana Cathia Magalhães, Claudio Rivera, Claudio Rivera, Claudio Rivera   +3 more
doaj   +1 more source

NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II–Hypertensive Mice

Stroke, 2022
Background: Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)–mediated ...
M. I. Bhuiyan, C. Young, Israt Jahan, Md Nabiul Hasan, Sydney Fischer, Nur Farah Meor Azlan, Mingjun Liu, A. Chattopadhyay, Huachen Huang, K. Kahle, Jinwei Zhang, S. Poloyac, B. Molyneaux, A. Straub, Xianming Deng, Delphine Gomez, Dandan Sun   +16 more
semanticscholar   +1 more source

Pretreatment with AQP4 and NKCC1 Inhibitors Concurrently Attenuated Spinal Cord Edema and Tissue Damage after Spinal Cord Injury in Rats

Frontiers in Physiology, 2018
Spinal cord injury (SCI) affects more than 2.5 million people worldwide. Spinal cord edema plays critical roles in the pathological progression of SCI.
Xiaodong Yan, Juanfang Liu, Xiji Wang, Wenhao Li, Jingyuan Chen, Honghui Sun   +5 more
doaj   +1 more source

Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation.

PLoS Biology, 2012
Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism
Tomas Garzon-Muvdi, Paula Schiapparelli, Colette ap Rhys, Hugo Guerrero-Cazares, Christopher Smith, Deok-Ho Kim, Lyonell Kone, Harrison Farber, Danielle Y Lee, Steven S An, Andre Levchenko, Alfredo Quiñones-Hinojosa   +11 more
doaj   +1 more source

NKCC1 Does Not Accumulate Chloride in Developing Retinal Neurons [PDF]

Journal of Neurophysiology, 2007
GABA excites immature neurons due to their relatively high intracellular chloride concentration. This initial high concentration is commonly attributed to the ubiquitous chloride cotransporter NKCC1, which uses a sodium gradient to accumulate chloride. Here we tested this hypothesis in immature retinal amacrine and ganglion cells.
Ling-Li, Zhang, Eric, Delpire, Noga, Vardi   +2 more
openaire   +2 more sources