Results 51 to 60 of about 10,422 (209)

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Ion Transporter NKCC1, Modulator of Neurogenesis in Murine Olfactory Neurons [PDF]

Journal of Biological Chemistry, 2015
Olfaction is one of the most crucial senses for vertebrates regarding foraging and social behavior. Therefore, it is of particular interest to investigate the sense of smell, its function on a molecular level, the signaling proteins involved in the process and the mechanism of required ion transport.
Haering, C., Kanageswaran, N., Bouvain, P., Scholz, P., Altmüller, J., Becker, C., Gisselmann, G., Wäring-Bischof, J., Hatt, H.   +8 more
openaire   +3 more sources

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures [PDF]

, 2014
Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults.
Delpire E, Goda S, Kaila K, Mares P, Randall J, Soul J, Volpe J, Walker PC   +7 more
core   +1 more source

COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination

American Journal of Physiology-Cell Physiology, 2013
Mice deficient in Na-K-2Cl cotransporter (NKCC1) have been generated by targeted disruption of the gene encoding NKCC1 involving the carboxy terminus (CT-NKCC1) but not the amino terminus. We hypothesize that the resulting physiological defects are due to loss of proteins interacting with CT-NKCC1.
Laura, Smith, Paul, Litman, Carole M, Liedtke   +2 more
openaire   +3 more sources

Functional kinomics establishes a critical node of volume-sensitive cation-Cl^- cotransporter regulation in the mammalian brain [PDF]

, 2016
This is the final version of the article. Available from the publisher via the DOI in this record.There is another record in ORE for this publication: http://hdl.handle.net/10871/33424Cell volume homeostasis requires the dynamically regulated transport ...
A Birmingham, A ElAli, A Madeira, A Roy, AA Altamirano, AC Vitari, AL Jackson, AM Ring, AV Sarthy, B Lenart, BD Manning, BE Xu, BF Dowd, BM Filippi, C Lytle, EK Hoffmann, F Hong, F Lang, FK Voss, G Begum, G Su, G Su, H Zhang, HY Wu, J Brillault, J Rinehart, J Zhang, JA Stokum, JM Simard, JO Thastrup, JV Olsen, K Piechotta, K Piechotta, K Pollizzi, K Strange, K Strange, KT Kahle, KT Kahle, L Cong, L Erokhova, M Amiry-Moghaddam, M Haas, M Zheng, MA Lawlor, MB Rust, ME O’Donnell, ME O’Donnell, ML Jennings, ML Jennings, N Manhas, NC Adragna, NC Adragna, NJ Abbott, P de Los Heros, PB Dunham, PS Lee, R Planells-Cases, R Syeda, RB Darman, S Heidari Nejad, S Michinaga, S Morgan-Lappe, SE Morgan-Lappe, SF Pedersen, SK Tahir, T Boettger, T Kuroiwa, T Mori, T Moriguchi, TJ Jentsch, Wallace F Marshall, X Lin, Y Durocher   +72 more
core   +3 more sources

Vasopressin and hyperosmolality regulate NKCC1 expression in rat OMCD [PDF]

Hypertension Research, 2009
Secretory-type Na-K-2Cl cotransporter (NKCC1) is known to play roles in both acid and sodium excretion, and is more abundant in dehydration. To determine the mechanisms by which dehydration stimulates NKCC1 expression, the effects of vasopressin, oxytocin and hyperosmolality on NKCC1 mRNA and protein expressions in the outer medullary collecting duct ...
Shiho, Wakamatsu, Hiroshi, Nonoguchi, Mika, Ikebe, Kenji, Machida, Yuichiro, Izumi, Hasiyet, Memetimin, Yushi, Nakayama, Takeshi, Nakanishi, Yukimasa, Kohda, Kimio, Tomita   +9 more
openaire   +2 more sources

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +1 more source

Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats

Frontiers in Pharmacology, 2022
Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride.
Shiva Hashemizadeh, Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini ravandi, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +9 more
doaj   +1 more source

NKCC1: Newly Found as a Human Disease-Causing Ion Transporter [PDF]

Function, 2020
AbstractAmong the electroneutral Na+-dependent chloride transporters, NKCC1 had until now evaded identification as a protein causing human diseases. The closely related SLC12A transporters, NKCC2 and NCC have been identified some 25 years ago as responsible for Bartter and Gitelman syndromes: two renal-dependent salt wasting disorders.
Rainelli Koumangoye, Lisa Bastarache, Eric Delpire   +2 more
openaire   +2 more sources

Inflammation alters cation chloride cotransporter expression in sensory neurons

Neurobiology of Disease, 2004
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza, Naomi L. Chillingworth, John A. Payne, Lucy F. Donaldson   +3 more
doaj   +1 more source