Results 51 to 60 of about 7,960 (193)

Beta-Amyloid (Aβ_1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus

Molecules, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief.
Patricia Lam, Chitra Vinnakota, Beatriz Calvo-Flores Guzmán, Julia Newland, Katie Peppercorn, Warren P. Tate, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky   +8 more
doaj   +1 more source

Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats [PDF]

Clinical and Experimental Otorhinolaryngology, 2012
ObjectivesFrom our previous study about the weak expressions of potassium-chloride (KCC2) and sodium-potassium-2 chloride (NKCC1) co-transporters in the lateral superior olive (LSO) in circling mice, we hypothesized that partially damaged cochlea of ...
Myung-Whan Suh, Seung Cheol Ahn
doaj   +1 more source

Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats

Frontiers in Pharmacology, 2022
Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride.
Shiva Hashemizadeh, Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini ravandi, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +9 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Inflammation alters cation chloride cotransporter expression in sensory neurons

Neurobiology of Disease, 2004
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza, Naomi L. Chillingworth, John A. Payne, Lucy F. Donaldson   +3 more
doaj   +1 more source

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

Cell Reports, 2019
Summary: mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1).
Wael L. Demian, Avinash Persaud, Chong Jiang, Étienne Coyaud, Shixuan Liu, Andras Kapus, Ran Kafri, Brian Raught, Daniela Rotin   +8 more
doaj   +1 more source

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source