Results 61 to 70 of about 10,422 (209)

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +1 more source

MAL/VIP17, a new player in the regulation of NKCC2 in the kidney [PDF]

, 2010
The renal-specific Na+-K+-2Cl- cotransporter (NKCC2) is the major salt transport pathway of the apical membrane of the mammalian thick ascending limb of Henle's loop.
Basco, Davide, Caplan, Michael J., Carmosino, Monica, Forbush, Biff, Procino, Giuseppe, Rizzo, Federica, Schaeren-Wiemers, Nicole, Svelto, Maria, Valenti, Giovanna   +8 more
core   +2 more sources

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

Cell Reports, 2019
Summary: mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1).
Wael L. Demian, Avinash Persaud, Chong Jiang, Étienne Coyaud, Shixuan Liu, Andras Kapus, Ran Kafri, Brian Raught, Daniela Rotin   +8 more
doaj   +1 more source

Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats [PDF]

Clinical and Experimental Otorhinolaryngology, 2012
ObjectivesFrom our previous study about the weak expressions of potassium-chloride (KCC2) and sodium-potassium-2 chloride (NKCC1) co-transporters in the lateral superior olive (LSO) in circling mice, we hypothesized that partially damaged cochlea of ...
Myung-Whan Suh, Seung Cheol Ahn
doaj   +1 more source

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]

, 2017
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder, Berdondini, Luca, De Pietri Tonelli, Davide, Marinaro, Federica   +3 more
core   +2 more sources

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus

Neuron, 2023
Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An incomplete understanding of this variably progressive condition has hampered the development of new therapies beyond serial neurosurgical interventions.
Cameron, Sadegh, Huixin, Xu, Jason, Sutin, Benoit, Fatou, Suhasini, Gupta, Aja, Pragana, Milo, Taylor, Peter N, Kalugin, Miriam E, Zawadzki, Osama, Alturkistani, Frederick B, Shipley, Neil, Dani, Ryann M, Fame, Zainab, Wurie, Pratik, Talati, Riana L, Schleicher, Eric M, Klein, Yong, Zhang, Michael J, Holtzman, Christopher I, Moore, Pei-Yi, Lin, Aman B, Patel, Benjamin C, Warf, W Taylor, Kimberly, Hanno, Steen, Mark L, Andermann, Maria K, Lehtinen   +26 more
openaire   +3 more sources

Immunohistochemical characterization of nodose cough receptor neurons projecting to the trachea of guinea pigs [PDF]

, 2008
BACKGROUND: Cough in guinea pigs is mediated in part by capsaicin-insensitive low threshold mechanoreceptors (cough receptors). Functional studies suggest that cough receptors represent a homogeneous population of nodose ganglia-derived sensory neurons ...
Mazzone, SB, McGovern, AE
core   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source