Results 61 to 70 of about 8,301 (197)
CNS Neuroscience & TherapeuticsHydrocephalus is characterized by secretion, circulation, and absorption disorder of cerebrospinal fluid (CSF) with high morbidity and complication rate.
Hao Xu +4 more
semanticscholar +1 more source
Mice lacking NKCC1 have normal olfactory sensitivity [PDF]
Physiology & Behavior, 2008 When olfactory receptor neurons respond to odors, a depolarizing Cl(-) efflux is a substantial part of the response. This requires that the resting neuron accumulate Cl(-) against an electrochemical gradient. In isolated olfactory receptor neurons, the Na(+)+K(+)+2Cl(-) cotransporter NKCC1 is essential for Cl(-) accumulation.
Department of Psychology, University of Florida, Gainesville, FL 32611, United States ( host institution ) +5 more
openaire +3 more sources
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.
PLoS ONE, 2020 The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang +6 more
doaj +1 more source
Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats
Frontiers in Pharmacology, 2022 Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride.
Shiva Hashemizadeh +9 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
High-resolution views and transport mechanisms of the NKCC1 and KCC transporters
Journal of Molecular Biology, 2021 Cation-chloride cotransporters (CCCs) are responsible for the coupled co-transport of Cl− with K+ and/or Na+ in an electroneutral manner. They play important roles in myriad fundamental physiological processes––from cell volume regulation to ...
Thomas A. Chew, Jinru Zhang, Liang Feng
semanticscholar +1 more source
Inflammation alters cation chloride cotransporter expression in sensory neurons
Neurobiology of Disease, 2004 Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza +3 more
doaj +1 more source
Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats [PDF]
Clinical and Experimental Otorhinolaryngology, 2012 ObjectivesFrom our previous study about the weak expressions of potassium-chloride (KCC2) and sodium-potassium-2 chloride (NKCC1) co-transporters in the lateral superior olive (LSO) in circling mice, we hypothesized that partially damaged cochlea of ...
Myung-Whan Suh, Seung Cheol Ahn
doaj +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Current Issues in Molecular BiologyAutism spectrum disorder (ASD) is thought to result from susceptibility genotypes and environmental risk factors. The offspring of women who experience pregnancy infection have an increased risk for autism.
Hai-Long Zhang +8 more
semanticscholar +1 more source