Results 81 to 90 of about 7,960 (193)
HBQ1 Acts as a Prognostic Biomarker and Tumor Suppressor Linked to Antigen Presentation in Glioma
Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.ABSTRACT Glioma is a highly aggressive brain tumor associated with substantial morbidity and mortality and with limited treatment options. This study investigates the functional role of Hemoglobin Subunit Theta 1 (HBQ1) in glioma and evaluates its potential as a prognostic biomarker. Using integrated bioinformatics approaches, we demonstrated that HBQ1
Cheng Xie +5 more
wiley +1 more source
Salt sensitivity of blood pressure in NKCC1-deficient mice
American Journal of Physiology-Renal Physiology, 2008 NKCC1 is a widely expressed isoform of the Na-2Cl-K cotransporter that mediates several direct and indirect vascular effects and regulates expression and release of renin. In this study, we used NKCC1-deficient (NKCC1−/−) and wild-type (WT) mice to assess day/night differences of blood pressure (BP), locomotor activity, and renin release and to study ...
Soo Mi, Kim +6 more
openaire +3 more sources
NKCC1 Regulates mTORC1 and p38-MAPK
, 2020 The Mammalian Target Of Rapamycin Complex1 (mTORC1) is a key regulator of cell growth and survival. It is activated by growth factors and by essential amino acids such as Leu. Influx of Leu into cells is mediated by the Leu transporter LAT1-4F2hc (LAT1).
Demian, Wael
core +1 more source
Dose-Response, 2019 Objective: The NKCC1 is a recognized tumorigenesis marker as it is important for tumor cell proliferation, differentiation, apoptosis, and tumor progression.
Milda Juknevičienė +6 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.We integrated DCE‐MRI‐based dural drainage function indicators (DDFIs) that reflect meningeal lymphatic vessels (mLVs) function into XGBoost models to predict the prognosis of intracranial malignant tumors. In a 2.5‐year follow‐up cohort of 100 patients, DDFIs remarkably improved the model's predictive performance, with a more significant enhancement ...
Lusen Ran +14 more
wiley +1 more source
NKCC1 and AE3 Appear to Accumulate Chloride in Embryonic Motoneurons
Journal of Neurophysiology, 2009 During early development, γ-aminobutyric acid (GABA) depolarizes and excites neurons, contrary to its typical function in the mature nervous system. As a result, developing networks are hyperexcitable and experience a spontaneous network activity that is important for several aspects of development.
Carlos, Gonzalez-Islas +2 more
openaire +3 more sources
Charakterisierung des Ionentransporters NKCC1 in der Chemosensorik
, 2016 Die olfaktorische Wahrnehmung wird hauptsächlich durch einen cAMP-vermittelten Signalweg gesteuert, welcher zu einem Ausstrom an Chloridionen führt und in der Depolarisation eines Neurons resultiert.
Haering, Claudia (M. Sc.)
core +1 more source
NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrain
Neural Development, 2011 From an early postnatal period and throughout life there is a continuous production of olfactory bulb (OB) interneurons originating from neuronal precursors in the subventricular zone.
Murray Kerren +2 more
doaj +1 more source
Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. [PDF]
PLoS ONE, 2015 The equilibrium potential for GABA-A receptor mediated currents (EGABA) in neonatal central neurons is set at a relatively depolarized level, which is suggested to be caused by a low expression of K+/Cl- co-transporter (KCC2) but a relatively high ...
Bo Yang +3 more
doaj +1 more source
Polyphenism Through RNA Chemical Modifications
Molecular Ecology, Volume 35, Issue 19, October 2026.ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley +1 more source