Results 81 to 90 of about 10,422 (209)

Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. [PDF]

PLoS ONE, 2012
Intracellular Cl(-) concentrations ([Cl(-)](i)) of sensory neurons regulate signal transmission and signal amplification. In dorsal root ganglion (DRG) and olfactory sensory neurons (OSNs), Cl(-) is accumulated by the Na(+)-K(+)-2Cl(-) cotransporter 1 ...
Nicole Schöbel, Debbie Radtke, Matthias Lübbert, Günter Gisselmann, Ramona Lehmann, Annika Cichy, Benjamin S P Schreiner, Janine Altmüller, Alan C Spector, Jennifer Spehr, Hanns Hatt, Christian H Wetzel   +11 more
doaj   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Off-Label Use of Bumetanide for Brain Disorders: An Overview

Frontiers in Neuroscience, 2019
Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and NKCC2.
Shivani C. Kharod, Seok Kyu Kang, Shilpa D. Kadam, Shilpa D. Kadam   +3 more
doaj   +1 more source

Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

Nature Communications, 2021
Brain plasticity declines with age. Here, the authors show that NKCC1 regulates oligodendrocyte activity, facilitating neuronal plasticity during juvenile. Inducing activation of oligodendrocytic NKCC1 results in restoration of neuronal plasticity in the
Yoshihiko Yamazaki, Yoshifumi Abe, Satoshi Fujii, Kenji F. Tanaka   +3 more
doaj   +1 more source

IRBIT a Master Regulator of Cell Physiology [PDF]

, 2017
(excerpt) Hormones and neurotransmitters regulate cell functions by binding to their receptors, which activate intracellular signaling and produce the physiological response [1].
Bouyer, Patrice G, Cook, Kelli, Petreska, Natasa   +2 more
core   +1 more source

Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. [PDF]

, 2015
BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks.
Dobolyi, Arpád, Héja, László, Kardos, Julianna, Pál, Ildikó   +3 more
core   +1 more source

Furosemide stimulation of parathormone in humans: role of the calcium-sensing receptor and the renin-angiotensin system. [PDF]

, 2015
Interactions between sodium and calcium regulating systems are poorly characterized but clinically important. Parathyroid hormone (PTH) levels are increased shortly after furosemide treatment by an unknown mechanism, and this effect is blunted by the ...
Anex, C., Bonny, O., Burnier, M., Forni Ogna, V., Maillard, M., Muller, M.E., Stoudmann, C., Wuerzner, G., Zweiacker, C.   +8 more
core   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Orexin‐A Inhibits Lipopolysaccharide‐Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling

Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026.
ABSTRACT It has been suggested that orexin‐A (OXA) exerts neuroprotective and anti‐inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed to investigate whether OXA could inhibit astrocyte migration induced by lipopolysaccharide (LPS ...
Hyunjin Shin, Sheu‐Ran Choi, Dong‐Wook Kang, Hyeryeong Lee, Jaehong Park, Miae Lee, Miok Bae, Yeonhee Ryu, Suk‐Yun Kang, Chang Woo Chae, Hyun‐Woo Kim   +10 more
wiley   +1 more source

Valproic Acid Inhibits NA-K-2CL Cotransporter RNA Expression in Male But Not in Female Rat Thymocytes

Dose-Response, 2019
Objective: The NKCC1 is a recognized tumorigenesis marker as it is important for tumor cell proliferation, differentiation, apoptosis, and tumor progression.
Milda Juknevičienė, Ingrida Balnytė, Angelija Valančiūtė, Vaiva Lesauskaitė, Jurate Stanevičiūtė, Rūta Curkūnavičiūtė, Donatas Stakišaitis   +6 more
doaj   +1 more source