Results 101 to 110 of about 8,301 (197)

Inhibition of Transglutaminase 2 Preserves Blood–Brain Barrier Integrity and Improves Neurological Outcomes After Experimental Traumatic Brain Injury in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
The article unraveled that inhibition or knockdown of TGM2 can restore blood–brain barrier (BBB) permeability and ameliorate neurological deficits and cognitive dysfunction in a mouse model of traumatic brain injury (TBI). Mechanistically, TGM2 likely modulates the IL‐17 signaling pathway to regulate MMP9 expression, thereby affecting BBB permeability.
Jieru Yang, Lihan Zhang, Xiancheng Qiu, Jiyang Wang, Ruicheng Yan, Jiasen Ye, Jianhua Peng, Yong Jiang   +7 more
wiley   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Orexin‐A Inhibits Lipopolysaccharide‐Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling

Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026.
ABSTRACT It has been suggested that orexin‐A (OXA) exerts neuroprotective and anti‐inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed to investigate whether OXA could inhibit astrocyte migration induced by lipopolysaccharide (LPS ...
Hyunjin Shin, Sheu‐Ran Choi, Dong‐Wook Kang, Hyeryeong Lee, Jaehong Park, Miae Lee, Miok Bae, Yeonhee Ryu, Suk‐Yun Kang, Chang Woo Chae, Hyun‐Woo Kim   +10 more
wiley   +1 more source

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors

The Journal of Physiology, Volume 604, Issue 7, Page 3077-3093, 1 April 2026.
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi, Caterina Ciani, Francesca Emma Mongelli, Rashid Giniatullin, Carmen Falcone, Giuliano Taccola   +5 more
wiley   +1 more source

Functional Analysis of Transmembrane Domain 3 in NKCC1 [PDF]

Biophysical Journal, 2011
We sought to determine the functional roles of residues in transmembrane domain (TM) 3 of human NKCC1 using tryptophan and cysteine scanning mutagenesis. We generated a structural alignment of the transmembrane domains of NKCC1 to the related APC transporters ApcT and AdiC, and obtained 3-D alignments using Modeller. Based on these alignments, residues
Somasekharan, Suma, Forbush, Biff
openaire   +1 more source

Research progress on Na+ ⁃ K+ ⁃ 2Cl- cotransporter 1 and its relationship to nervous system diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Na+ ⁃ K+ ⁃ 2Cl- cotransporter 1 (NKCC1) which plays an important role in the dynamic balance of Cl- ions, is one of the cation⁃chloride cotransporter. It is a membrane protein that transferred the mediates Na+ , K+ and Cl- .
FU Xu⁃yang, SUN Jian⁃qi , LÜ Jun, SHI Rui⁃li   +3 more
doaj  

Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice

Cell Biochemistry and Function, Volume 44, Issue 3, March 2026.
ABSTRACT Posthemorrhagic hydrocephalus is a severe complication to intraventricular hemorrhage. The condition results in enlarged brain ventricles and increased intracranial pressure due to accumulation of cerebrospinal fluid (CSF). In this study, two mouse models of intraventricular hemorrhage were investigated: injection of lysed red blood cells ...
Laura Øllegaard Johnsen, Rasmus Herløw, Rasmus West Knopper, Thomas Beck Lindhardt, Brian Hansen, Helle Hasager Damkier   +5 more
wiley   +1 more source

Salt sensitivity of blood pressure in NKCC1-deficient mice

American Journal of Physiology-Renal Physiology, 2008
NKCC1 is a widely expressed isoform of the Na-2Cl-K cotransporter that mediates several direct and indirect vascular effects and regulates expression and release of renin. In this study, we used NKCC1-deficient (NKCC1−/−) and wild-type (WT) mice to assess day/night differences of blood pressure (BP), locomotor activity, and renin release and to study ...
Soo Mi, Kim, Christoph, Eisner, Robert, Faulhaber-Walter, Diane, Mizel, Susan M, Wall, Josephine P, Briggs, Jurgen, Schnermann   +6 more
openaire   +3 more sources

¬Immunolocalization of cation-chloride cotransporters in the developing and mature spinal cord of opossums, Monodelphis domestica

Frontiers in Neuroanatomy, 2013
Spinal inhibition is required to generate coordinated outputs between antagonistic muscles during locomotion. It relies on low neuronal chloride concentration set by two cation-chloride cotransporters, NKCC1 and KCC2 which, respectively, pumps Cl- in or ...
Ha-Loan ePhan, Jean-François ePflieger
doaj   +1 more source

Cab39 modulates SPAK/OSR1 activation of NKCC1

The FASEB Journal, 2013
Calcium binding protein 39 (Cab39) is a scaffolding protein that stabilizes a heterotrimeric protein complex that modulates the activity of the adenosine mono‐phosphate kinase which regulates cellular energy homeostasis. Cab39 also modulates SPAK (Ste20 related Proline Alanine rich Kinase) and OSR1 (Oxidative stress responsive ...
José Ponce‐Coria, Kerri Rios, Kenneth B. Gagnon, Eric Delpire   +3 more
openaire   +1 more source