Results 111 to 120 of about 10,422 (209)
Telemetric blood pressure studies in NKCC1‐deficient mice
The FASEB Journal, 2007 Blood pressure measurements by tail‐cuff have shown reduced levels in NKCC1‐deficient mice (NKCC1−/−). By radiotelemetry 24h mean arterial blood pressure (MAP) was not different in NKCC1−/− and WT mice (108 ± 2 vs. 110 ± 2 mm Hg; n=19 vs. n=7). MAP was not altered by either 1 week low (0.03%) or high Na intake (8%) in WT mice.
Soo Mi Kim +6 more
openaire +1 more source
Functional Analysis of Transmembrane Domain 3 in NKCC1 [PDF]
Biophysical Journal, 2011 We sought to determine the functional roles of residues in transmembrane domain (TM) 3 of human NKCC1 using tryptophan and cysteine scanning mutagenesis. We generated a structural alignment of the transmembrane domains of NKCC1 to the related APC transporters ApcT and AdiC, and obtained 3-D alignments using Modeller. Based on these alignments, residues
Somasekharan, Suma, Forbush, Biff
openaire +1 more source
Symptomatic seizures in preterm newborns: a review on clinical features and prognosis [PDF]
, 2018 Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular ...
Corsello G +4 more
core +2 more sources
The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR [PDF]
, 2016 Optimal fetal lung growth requires anion-driven fluid secretion into the lumen of the developing organ. The fetus is hypercalcemic compared to the mother and here we show that in the developing human lung this hypercalcaemia acts on the extracellular ...
Brennan, Sarah C. +10 more
core +2 more sources
A human colonic crypt culture system to study regulation of stem cell-driven tissue renewal and physiological function [PDF]
, 2015 The intestinal epithelium is one of the most rapidly renewing tissues in the human body and fulfils vital physiological roles such as barrier function and transport of nutrients and fluid.
A Reynolds +18 more
core +1 more source
NKCC1 and AE3 Appear to Accumulate Chloride in Embryonic Motoneurons
Journal of Neurophysiology, 2009 During early development, γ-aminobutyric acid (GABA) depolarizes and excites neurons, contrary to its typical function in the mature nervous system. As a result, developing networks are hyperexcitable and experience a spontaneous network activity that is important for several aspects of development.
Carlos, Gonzalez-Islas +2 more
openaire +3 more sources
BMC Neuroscience, 2008 Background During development the switch from a depolarizing to a hyperpolarizing action of GABA is a consequence of a decrease of the Na+-K+-2Cl- co-transporter (NKCC1, Cl--uptake) and increase of the K+-Cl- co-transporter (KCC2, Cl--extrusion ...
Turchinovich Andrey +3 more
doaj +1 more source
Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth [PDF]
, 2017 During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment.
Crow, Ailey K. +13 more
core +1 more source
Structural and functional roles of KCC2 in developing cortex [PDF]
, 2008 Cation chloride cotransporters (CCCs) are critical for controlling intracellular chloride homeostasis. The CCC family is composed of four isoforms of K-Cl cotransporters (KCC1-4), two isoforms of Na-K-2Cl cotransporters (NKCC1-2), one Na-Cl cotransporter
Li, Hong
core
Modulation of Chloride Homeostasis by Inflammatory Mediators in Dorsal Root Ganglion Neurons [PDF]
, 2008 Background Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl- accumulation in sensory endings establishes the driving force for depolarizing, and even excitatory, Cl ...
Katharina Funk +5 more
core +1 more source