Results 111 to 120 of about 8,301 (197)

NKCC1: tales from the dark side of the crypt [PDF]

The Journal of Physiology, 2007
Intestinal electrolyte secretion consist of several fundamental components: a basolateral uptake pathway, identified as the Na+–K+–Cl− cotransporter (NKCC1) (Payne et al. 1995) and an apical secretory pathway. NKCCs are highly conserved across organ and species, serving essential ion secretory and absorptive functions. Distinct regulatory mechanisms
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Elevated intracellular chloride level in albino visual cortex neurons is mediated by Na-K-Cl co-transporter

BMC Neuroscience, 2008
Background During development the switch from a depolarizing to a hyperpolarizing action of GABA is a consequence of a decrease of the Na+-K+-2Cl- co-transporter (NKCC1, Cl--uptake) and increase of the K+-Cl- co-transporter (KCC2, Cl--extrusion ...
Turchinovich Andrey, Diykov Dmitry, Zoidl Georg, Hoffmann Klaus-Peter   +3 more
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Structure and Function of the Transporter NKCC1 [PDF]

Biophysical Journal, 2018
Corinne Portioli, Marco De Vivo, Ming Zhou, Laura Cancedda   +3 more
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Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses

Astrocytic NKCC1 inhibits seizures by buffering Cl- and antagonizing neuronal NKCC1 at GABAergic synapses
doctoral 医学系研究科 A pathological excitatory action of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) has been observed in epilepsy. Blocking the Cl⁻ importer NKCCl with bumetanide is expected to reduce the neuronal intracellular Cl⁻ concentration ([Cl⁻]i) and thereby attenuate the excitatory GABA response.
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The Ion-Transporter NKCC1 as a Target for Brain Diseases [PDF]

Biophysical Journal, 2020
Corinne Portioli, Annalisa Savardi, Zhenning Ren, Marco De Vivo, Ming Zhou, Laura Cancedda   +5 more
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Hypertonicity-induced RNF183 targets NKCC1 to protect kidney collecting duct cells but induces apoptosis in colon cells. [PDF]

Commun Biol
Okamoto T, Higashi Y, Takemoto M, Matsuhisa K, Sato S, Saito A, Omura I, Kamikawa Y, Imaizumi K, Kaneko M.   +9 more
europepmc   +1 more source

Chasing the ghost in the code: highlighting the mystery of a rare genetic condition. [PDF]

Am J Physiol Cell Physiol
Delpire E.
europepmc   +1 more source

Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse. [PDF]

Int J Mol Sci
Dumitrescu D, Oprea S, Tulin R, Dumitru AV, Munteanu O, Pariza G.   +5 more
europepmc   +1 more source

Combined use of Bumetanide and MGE cell transplantation alleviates neuropathic pain and its mechanism after spinal cord injury in mice. [PDF]

Front Immunol
Yu Y, Wang F.
europepmc   +1 more source

Chloride homeostasis dysfunction drives hyperactivation of corticotropin-releasing factor-expressing neurons in the amygdala in stress-induced hypertension. [PDF]

J Clin Invest
Ma H, Zhang Y, Guo X, Zhao Q, Yang P, Liu Y, Guan Y, Wei Y, Ma H.   +8 more
europepmc   +1 more source