Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]
Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C +4 more
core +1 more source
Hippocampe et épilepsie : données issues des tissus humains [PDF]
International audienceSurgical removal of the epileptogenic zone provides an effective therapy for several focal epileptic syndromes. This surgery offers the opportunity to study pathological activity in living human tissue for pharmacoresistant partial ...
Blauwblomme, Thomas +2 more
core +5 more sources
Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi +5 more
wiley +1 more source
Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. [PDF]
The equilibrium potential for GABA-A receptor mediated currents (EGABA) in neonatal central neurons is set at a relatively depolarized level, which is suggested to be caused by a low expression of K+/Cl- co-transporter (KCC2) but a relatively high ...
Bo Yang +3 more
doaj +1 more source
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo [PDF]
Mutations in WNK1 and WNK4 kinase genes have been shown to cause a human hereditary hypertensive disease, pseudohypoaldosteronism type II (PHAII). We previously discovered that WNK kinases phosphorylate and activate OSR1/SPAK kinases that regulate renal ...
Alessi, Dario R. +7 more
core +3 more sources
Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice
ABSTRACT Posthemorrhagic hydrocephalus is a severe complication to intraventricular hemorrhage. The condition results in enlarged brain ventricles and increased intracranial pressure due to accumulation of cerebrospinal fluid (CSF). In this study, two mouse models of intraventricular hemorrhage were investigated: injection of lysed red blood cells ...
Laura Øllegaard Johnsen +5 more
wiley +1 more source
NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrain
From an early postnatal period and throughout life there is a continuous production of olfactory bulb (OB) interneurons originating from neuronal precursors in the subventricular zone.
Murray Kerren +2 more
doaj +1 more source
Long-term pilocarpine treatment improves salivary flow in irradiated mice. [PDF]
学位記番号 ...
Taniguchi, Akie +2 more
core
Both Ways at Once: Keeping Small Airways Clean. [PDF]
The small airways of the lungs are under constant assault from the pathogens and debris in the air that they must conduct to alveoli. Although hygiene is of paramount importance for respiratory health, the underlying principles of airway clearance have ...
Quinton, Paul M
core +1 more source
Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)
High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao +6 more
wiley +1 more source

