Results 71 to 80 of about 10,422 (209)

Cab39 modulates SPAK/OSR1 activation of NKCC1

The FASEB Journal, 2013
Calcium binding protein 39 (Cab39) is a scaffolding protein that stabilizes a heterotrimeric protein complex that modulates the activity of the adenosine mono‐phosphate kinase which regulates cellular energy homeostasis. Cab39 also modulates SPAK (Ste20 related Proline Alanine rich Kinase) and OSR1 (Oxidative stress responsive ...
José Ponce‐Coria, Kerri Rios, Kenneth B. Gagnon, Eric Delpire   +3 more
openaire   +1 more source

Cation Chloride Cotransporter NKCC1 Operates through a Rocking-Bundle Mechanism

Journal of the American Chemical Society, 2023
The sodium, potassium, and chloride cotransporter 1 (NKCC1) plays a key role in tightly regulating ion shuttling across cell membranes. Lately, its aberrant expression and function have been linked to numerous neurological disorders and cancers, making it a novel and highly promising pharmacological target for therapeutic interventions.
Manuel José Ruiz Munevar, Valerio Rizzi, Corinne Portioli, Pietro Vidossich, Erhu Cao, Michele Parrinello, Laura Cancedda, Marco De Vivo   +7 more
openaire   +2 more sources

The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice

Frontiers in Physiology, 2017
Na+:K+:2Cl− cotransporters (NKCCs) belong to the SLC12A family of cation-coupled Cl− transporters. We investigated whether enamel-producing mouse ameloblasts express NKCCs.
Rozita Jalali, Rozita Jalali, Johannes C. Lodder, Behrouz Zandieh-Doulabi, Dimitra Micha, James E. Melvin, Marcelo A. Catalan, Marcelo A. Catalan, Huibert D. Mansvelder, Pamela DenBesten, Antonius Bronckers   +10 more
doaj   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

Salt sensitivity of blood pressure in NKCC1-deficient mice

American Journal of Physiology-Renal Physiology, 2008
NKCC1 is a widely expressed isoform of the Na-2Cl-K cotransporter that mediates several direct and indirect vascular effects and regulates expression and release of renin. In this study, we used NKCC1-deficient (NKCC1−/−) and wild-type (WT) mice to assess day/night differences of blood pressure (BP), locomotor activity, and renin release and to study ...
Soo Mi, Kim, Christoph, Eisner, Robert, Faulhaber-Walter, Diane, Mizel, Susan M, Wall, Josephine P, Briggs, Jurgen, Schnermann   +6 more
openaire   +3 more sources

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

Frontiers in Molecular Neuroscience, 2023
The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature ...
Domenico Del Turco, Mandy H. Paul, Jessica Schlaudraff, Julia Muellerleile, Fran Bozic, Mario Vuksic, Peter Jedlicka, Peter Jedlicka, Thomas Deller   +8 more
doaj   +1 more source

Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers [PDF]

, 2018
Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3 - secretion to total cyclic adenosine monophosphate (cAMP ...
Avula, L.R. (Leela Rani), Donowitz, M. (Mark), Foulke-Abel, J. (Jennifer), Jonge, H.R. (Hugo) de, Singh, V. (Varsha), Tse, C.-M. (Chung-Ming), Yin, J. (Jianyi)   +6 more
core   +5 more sources

Human iPSC‐derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by disrupted excitatory–inhibitory (E:I) balance and impaired synaptic function, yet current treatments fail to repair these fundamental circuit impairments. METHODS Human induced pluripotent stem cell‐derived post‐mitotic medial ganglionic eminence‐originated inhibitory neurons (MGE‐pINs)
Xinzhe Zhang, Gaojie Wang, Haodong Chen, Ye Sun, Ziteng Wangliu, Lijing Wang, Miao Sun, Qing Liu, Xue Zhang   +8 more
wiley   +1 more source

Neuronal Chloride Accumulation in Olfactory Epithelium of Mice Lacking NKCC1 [PDF]

Journal of Neurophysiology, 2006
When stimulated with odorants, olfactory receptor neurons (ORNs) produce a depolarizing receptor current. In isolated ORNs, much of this current is caused by an efflux of Cl−. This implies that the neurons have one or more mechanisms for accumulating cytoplasmic Cl− at rest. Whether odors activate an efflux of Cl− in intact olfactory epithelium, where
William T, Nickell, Nancy K, Kleene, Robert C, Gesteland, Steven J, Kleene   +3 more
openaire   +2 more sources